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Macrene Actives Moisturizing High Performance Face Cream with Peptides
Macrene Actives

Macrene Actives Moisturizing High Performance Face Cream with Peptides

Efficacy100/100IrritancyHigh
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Works for

3 of 3 advertised claims delivered

Evens skin tone
Acetyl glucosamine, Resveratrol + 2 more
Strong evidence
What the product description says
“Skin Type Normal, Dry, Combination, and Oily Skincare Concerns Fine Lines and Wrinkles, Dullness, and Uneven Texture Formulation Cream Highlighted Ingredients , Copper Peptides Visibly firm and tone skin while minimizing fine lines and wrinkles.”
Source: Sephora

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: acetyl glucosamine

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: alanine, resveratrol.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Acetyl glucosamineKey activeEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~1.5–1.8%
ResveratrolEffect: LowHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.65–0.95%
AlanineEffect: LowAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.35–0.6%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~1.9–2.3%
Anti-aging
Acetyl glucosamine, Threonine + 7 more
Strong evidence
What the product description says
“Skin Type Normal, Dry, Combination, and Oily Skincare Concerns Fine Lines and Wrinkles, Dullness, and Uneven Texture Formulation Cream Highlighted Ingredients , Copper Peptides Visibly firm and tone skin while minimizing fine lines and wrinkles.”
Source: Sephora

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains acetyl glucosamine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: arabidopsis thaliana extract, aspartic acid, resveratrol, serine, threonine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Acetyl glucosamineKey activeEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~1.5–1.8%
ThreonineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.35–0.65%
ResveratrolKey activeEffect: MediumHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.65–0.95%
Arabidopsis thaliana extractKey activeEffect: MediumPlant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking~0.55–0.8%
Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.35–0.6%
SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.35–0.6%
Ilex paraguariensis leaf extractEffect: LowA plant extract that can help neutralize free radicals in skin. Can contain fragrand compounds like linalool that can be irritating~0.35–0.6%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~1.9–2.3%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%
Moisturizing
Acetyl glucosamine, Tremella fuciformis sporocarp extract + 28 more
Strong evidence
What the product description says
“Moisturizing High Performance Face Cream with Peptides”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, helianthus annuus seed oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl glucosamine

Tremella fuciformis sporocarp extractKey active· HumectantEffect: HighMushroom extract that helps attract water to the upper layer of the skin~0.35–0.65%
Micrococcus lysateKey activeEffect: HighConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"~0.5–0.75%
Palmaria palmata extractKey activeEffect: HighRed algae extract that helps attract water to the upper layer of the skin~0.4–0.6%
PcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.35–0.65%
Scenedesmus rubescens extractKey activeEffect: HighA micro-algae extract that might help attract water to the upper layer of the skin, support its barrier function, amd might help neutralize free radicals, but evidence of effectiveness in skin is lacking~0.55–0.85%
SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.35–0.6%
Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.35–0.65%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.35–0.65%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~4.9–6%
Theobroma cacao seed butterKey active· EmollientEffect: HighHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect~0.4–0.65%
ThreonineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.35–0.65%
Acetyl glucosamineHero· HumectantEffect: HighAn effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin~1.5–1.8%
AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.35–0.6%
ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.35–0.6%
Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.35–0.6%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.2–5.2%
GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.35–0.6%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.6%
Helianthus annuus seed oil unsaponifiablesKey active· EmollientEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~1.7–2.1%
HistidineKey active· HumectantEffect: High~0.35–0.6%
Hydrolyzed hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. A version of it is naturally present in skin~0.3–0.55%
IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.35–0.6%
ProlineKey activeEffect: Medium~0.4–0.6%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~2.6–3.2%
Hydrogenated ethylhexyl olivateKey active· EmollientEffect: MediumHelps soften the upper layer of the skin~2.4–3%
Plankton extractKey activeEffect: MediumCan help attract water to the upper layer of the skin~0.55–0.8%
Hydrogenated olive oil unsaponifiablesKey active· EmollientEffect: MediumHelp soften the upper layer of the skin~0.9–1.1%
Stearic acid· EmollientEffect: LowHelps oil and water mix together and works as an emollient~1.3–1.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.45–0.65%
Anti-oxidation
Not advertised by the brand · Resveratrol, Ilex paraguariensis leaf extract + 11 more
Strong evidence

This product contains antioxidants (resveratrol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - ilex paraguariensis leaf extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

ResveratrolKey activeEffect: HighHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone~0.65–0.95%
Ilex paraguariensis leaf extractKey activeEffect: MediumA plant extract that can help neutralize free radicals in skin. Can contain fragrand compounds like linalool that can be irritating~0.35–0.6%
Tremella fuciformis sporocarp extractEffect: LowMushroom extract that helps attract water to the upper layer of the skin~0.35–0.65%
Micrococcus lysateEffect: LowConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"~0.5–0.75%
CaffeineEffect: LowMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes~0.35–0.65%
Theobroma cacao seed butterEffect: LowHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect~0.4–0.65%
Scenedesmus rubescens extractEffect: LowA micro-algae extract that might help attract water to the upper layer of the skin, support its barrier function, amd might help neutralize free radicals, but evidence of effectiveness in skin is lacking~0.55–0.85%
Palmaria palmata extractEffect: LowRed algae extract that helps attract water to the upper layer of the skin~0.4–0.6%
ErgothioneineUnder-dosedEffect: HighCan help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking~0.45–0.7%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.2–0.35%
Tetrahexyldecyl ascorbateUnder-dosedEffect: HighBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~1.9–2.3%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.15–0.25%
BisabololEffect: Low, below effective doseAn active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties~0.3–0.55%

Can it cause trouble?

Irritancy
4 strong irritants: Ilex paraguariensis leaf extract, Chrysanthemum parthenium extract + 2 more — patch-test recommended
High risk
We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Ilex paraguariensis leaf extractA plant extract that can help neutralize free radicals in skin. Can contain fragrand compounds like linalool that can be irritatingHigh~0.35–0.6%est.
Chrysanthemum parthenium extractCould have anti-inflammatory effect on skin, but can be irritating as well. Can be added to products for its smellHigh~0.35–0.6%est.
AlcoholCan be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial propertiesHigh~0.35–0.65%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.15–0.25%est.
Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~1.9–2.3%est.
ResveratrolHelps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin toneMedium~0.65–0.95%est.
Scenedesmus rubescens extractA micro-algae extract that might help attract water to the upper layer of the skin, support its barrier function, amd might help neutralize free radicals, but evidence of effectiveness in skin is lackingMedium~0.55–0.85%est.
Plankton extractCan help attract water to the upper layer of the skinMedium~0.55–0.8%est.
Arabidopsis thaliana extractPlant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lackingMedium~0.55–0.8%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.35–0.65%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.35–0.65%est.
Sodium stearoyl glutamateHelps oil and water mix togetherMedium~0.45–0.7%est.
Potassium sorbateA preservativeMedium~0.2–0.4%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.05–0.15%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Plankton extractCan help attract water to the upper layer of the skin3/5~0.55–0.8%est.
Theobroma cacao seed butterHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect3/5~0.4–0.65%est.
Palmaria palmata extractRed algae extract that helps attract water to the upper layer of the skin3/5~0.4–0.6%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Squalane~4.9–6%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Glycerin~4.2–5.2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetyl alcohol~2.6–3.2%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Hydrogenated ethylhexyl olivate~2.4–3%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Hydrogenated ethylhexyl olivate
Tetrahexyldecyl ascorbate~1.9–2.3%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin toneAnti-aging

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate
Helianthus annuus seed oil unsaponifiables~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil unsaponifiables
Acetyl glucosamine~1.5–1.8%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingEvens skin toneAnti-agingExfoliation

An effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin

More about Acetyl glucosamine
Stearic acid~1.3–1.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Sorbitan stearate~1–1.2%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Sorbitan stearate
Hydrogenated olive oil unsaponifiables~0.9–1.1%
Key active
Irritation risk
Low
Works for
Moisturizing

Help soften the upper layer of the skin

More about Hydrogenated olive oil unsaponifiables
Copper lysinate/prolinate~0.65–0.95%
Formula
Irritation risk
Low
More about Copper lysinate/prolinate
Resveratrol~0.65–0.95%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingEvens skin tone

Helps neutralize free radicals in skin and might help reduce fine lines and wrinkles, as well as even out the skin tone

More about Resveratrol
Scenedesmus rubescens extract~0.55–0.85%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

A micro-algae extract that might help attract water to the upper layer of the skin, support its barrier function, amd might help neutralize free radicals, but evidence of effectiveness in skin is lacking

More about Scenedesmus rubescens extract
Plankton extract~0.55–0.8%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Can help attract water to the upper layer of the skin

More about Plankton extract
Arabidopsis thaliana extract~0.55–0.8%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-aging

Plant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking

More about Arabidopsis thaliana extract
Micrococcus lysate~0.5–0.75%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidation

Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"

More about Micrococcus lysate
Leontopodium alpinum flower/leaf extract~0.5–0.7%
Formula
Irritation risk
Low
More about Leontopodium alpinum flower/leaf extract
Ergothioneine~0.45–0.7%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidation

Can help neutralize free radicals in skin. Preliminary studies show that it can be more effective than coenzyme Q10 but studies on effective concentration for topical applications are lacking

More about Ergothioneine
Coffea robusta seed extract~0.45–0.65%
Formula
Irritation risk
Low
More about Coffea robusta seed extract
Ilex paraguariensis leaf extract~0.35–0.6%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-oxidationAnti-aging

A plant extract that can help neutralize free radicals in skin. Can contain fragrand compounds like linalool that can be irritating

More about Ilex paraguariensis leaf extract
Chrysanthemum parthenium extract~0.35–0.6%
Irritant · high
Irritation risk
High

Could have anti-inflammatory effect on skin, but can be irritating as well. Can be added to products for its smell

More about Chrysanthemum parthenium extract
Theobroma cacao seed butter~0.4–0.65%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-dandruff

Helps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect

More about Theobroma cacao seed butter
Palmaria palmata extract~0.4–0.6%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidation

Red algae extract that helps attract water to the upper layer of the skin

More about Palmaria palmata extract
Tremella fuciformis sporocarp extract~0.35–0.65%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

Mushroom extract that helps attract water to the upper layer of the skin

More about Tremella fuciformis sporocarp extract
Caffeine~0.35–0.65%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Bisabolol~0.3–0.55%
Formula
Irritation risk
Low
Works for
Anti-inflammatoryReduces irritationAnti-oxidation

An active component of chamomile plant that historically has been used to calm down irritated skin. A recent study shows that bisabolol indeed can have some anti-inflammatory effect on skin, even though conclusive data is lacking. Bisabolol has a sweet floral scent and can be added to products for its aromatic properties

More about Bisabolol
Sodium lactate~0.35–0.65%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Arginine~0.35–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Aspartic acid~0.35–0.6%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid
Glycine~0.35–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine
Alanine~0.35–0.6%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine
Serine~0.35–0.6%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine
Valine~0.35–0.6%
Formula
Irritation risk
Low
More about Valine
Proline~0.4–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Proline
Threonine~0.35–0.65%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Threonine
Isoleucine~0.35–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine
Histidine~0.35–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Histidine
Phenylalanine~0.35–0.65%
Formula
Irritation risk
Low
More about Phenylalanine
Pca~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Pca
Sodium pca~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Lecithin~0.45–0.65%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Methylglucoside phosphate~0.35–0.6%
Formula
Irritation risk
Low
More about Methylglucoside phosphate
Alcohol~0.35–0.65%
Irritant · high
Irritation risk
High
Works for
Antibacterial

Can be drying and contribute to skin irritation. Used in formulars to dissolve other ingredients, create a thinner product consistency or for its antibacterial properties

More about Alcohol
Xanthan gum~0.4–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Sodium stearoyl glutamate~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Sodium stearoyl glutamate
Sodium methyl stearoyl taurate~0.65–1%
Formula
Irritation risk
Low
Works for
Cleansing
More about Sodium methyl stearoyl taurate
Hydroxypropyl methylcellulose stearoxy ether~0.35–0.6%
Formula
Irritation risk
Low

Helps create a thicker product formulation

More about Hydroxypropyl methylcellulose stearoxy ether
Sodium phytate~0.3–0.6%
Formula
Irritation risk
Low

Used to stabilize product formulations

More about Sodium phytate
Hydrogenated lecithin~0.35–0.6%
Formula
Irritation risk
Low
Works for
Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin
Hydrolyzed hyaluronic acid~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. A version of it is naturally present in skin

More about Hydrolyzed hyaluronic acid
Helianthus annuus seed oil~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Phenoxyethanol~0.3–0.5%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

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Sodium benzoate~0.25–0.45%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Potassium sorbate~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Tocopherol~0.2–0.35%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Oryza sativa bran extract~0.15–0.3%
Formula
Irritation risk
Low

Used to thicken the product consistency

More about Oryza sativa bran extract
Rosmarinus officinalis leaf extract~0.15–0.25%
Irritant · high
Irritation risk
High
Works for
Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Helianthus annuus seed extract~0.15–0.3%
Formula
Irritation risk
Low
More about Helianthus annuus seed extract
Maltodextrin~0.1–0.2%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Citric acid~0.05–0.15%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Water, Squalane, Glycerin, Cetyl alcohol, Hydrogenated ethylhexyl olivate, Tetrahexyldecyl ascorbate, Helianthus annuus seed oil unsaponifiables, Acetyl glucosamine, Stearic acid, Sorbitan stearate, Hydrogenated olive oil unsaponifiables, Copper lysinate/prolinate, Resveratrol, Scenedesmus rubescens extract, Plankton extract, Arabidopsis thaliana extract, Micrococcus lysate, Leontopodium alpinum flower/leaf extract, Ergothioneine, Coffea robusta seed extract, Ilex paraguariensis leaf extract, Chrysanthemum parthenium extract, Theobroma cacao seed butter, Palmaria palmata extract, Tremella fuciformis sporocarp extract, Caffeine, Bisabolol, Sodium lactate, Arginine, Aspartic acid, Glycine, Alanine, Serine, Valine, Proline, Threonine, Isoleucine, Histidine, Phenylalanine, Pca, Sodium pca, Lecithin, Methylglucoside phosphate, Alcohol, Xanthan gum, Sodium stearoyl glutamate, Sodium methyl stearoyl taurate, Hydroxypropyl methylcellulose stearoxy ether, Sodium phytate, Hydrogenated lecithin, Hydrolyzed hyaluronic acid, Helianthus annuus seed oil, Phenoxyethanol, Sodium benzoate, Potassium sorbate, Tocopherol, Oryza sativa bran extract, Rosmarinus officinalis leaf extract, Helianthus annuus seed extract, Maltodextrin, Citric acid

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Product summary

"Macrene Actives - Moisturizing High Performance Face Cream with Peptides" has a good moisturizing formula. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Humectants in this product (acetyl glucosamine, alanine, arginine, aspartic acid and glycerin) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Helianthus annuus seed oil unsaponifiables, theobroma cacao seed butter, arginine, helianthus annuus seed oil and squalane in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin e, lecithin, ergothioneine and tetrahexyldecyl ascorbate

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 45 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamagencbi.nlm.nih.gov
  3. 3
    Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacysciencedirect.com
  4. 4
    The effect of N-acetyl-glucosamine on stratum corneum desquamation and water content in human skinncbi.nlm.nih.gov
  5. 5
    Glucosamine: an ingredient with skin and other benefitsncbi.nlm.nih.gov
  6. 6
    Genomic expression changes induced by topical N-acetyl glucosamine in skin equivalent cultures in vitroonlinelibrary.wiley.com
Macrene Actives Moisturizing High Performance Face Cream with Peptides
Macrene ActivesMoisturizing High Performance Face Cream with Peptides
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