La Roche-Posay Redermic R Anti-Wrinkle Retinol Night Cream

La Roche-Posay Redermic R Anti-Wrinkle Retinol Night Cream

Efficacy58/100IrritancyMedium
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Works for

2 of 3 advertised claims delivered

Anti-aging
4 ingredients credited for this claim
Strong evidence
What the product description says
“Redermic R Anti-Wrinkle Retinol Night Cream”
From product name

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: dipeptide-1.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.45–1.1%
Dipeptide-1Key activeEffect: MediumA type of peptide. Helps attract water to the upper layer of the skin and might have anti-aging benefits~0.1–0.35%
Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.05–0.1%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.05–0.15%
Moisturizing
12 ingredients credited for this claim
Good evidence
What the product description says
“Redermic R Anti-Wrinkle Retinol Night Cream”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: glycine soja oil, cetearyl alcohol.

Dipeptide-1Key activeEffect: HighA type of peptide. Helps attract water to the upper layer of the skin and might have anti-aging benefits~0.1–0.35%
Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~1.2–1.8%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.6–1.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.5–5.3%
AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.45–1.1%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~1.4–2.1%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.15–0.6%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.35–0.85%
Isohexadecane· EmollientEffect: LowImproves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent~1.1–1.6%
Isostearyl neopentanoate· EmollientEffect: LowUsed to create a nice product texture and helps soften the upper layer of the skin. Could be comedogenic~4.6–6.9%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~2.6–4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.05–0.15%
Evens skin tone
1 ingredient credited for this claim
Weak evidence
What the product description says
“SPECIFICALLY FORMULATED FOR Specifically formulated to combat the visible signs of anti-ageing including wrinkles, uneven skin tone, crows feet, dark spots, forehead and lip lines.”
Source: La roche posay UK

Effective ingredients missing or their concentration is too low

Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.05–0.1%

Can it cause trouble?

Irritancy
2 strong irritants: Parfum, Retinyl palmitate
Medium risk
We flagged 9 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~2.6–4%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.15–0.7%est.
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.05–0.1%est.
Isostearyl neopentanoateUsed to create a nice product texture and helps soften the upper layer of the skin. Could be comedogenicMedium~4.6–6.9%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~2.1–3.1%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~1.2–1.8%est.
Hydroxyethylpiperazine ethane sulfonic acidUsed to regulate product's pH, but can be also used as an exfoliator when included in higher concentrations. There is a controversy about whether it can generate free radicals and induce skin cell damage when used in topical productsMedium~0.4–0.9%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.35–0.85%est.
Disodium edtaStabilizes the product formulationMedium~0.1–0.4%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Isostearyl neopentanoateUsed to create a nice product texture and helps soften the upper layer of the skin. Could be comedogenic2/5~4.6–6.9%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~1.4–2.1%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~1.2–1.8%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Isostearyl neopentanoate~4.6–6.9%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

Used to create a nice product texture and helps soften the upper layer of the skin. Could be comedogenic

More about Isostearyl neopentanoate
Glycerin~3.5–5.3%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Octyldodecanol
Not recognized
Propylene glycol~2.6–4%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Pentylene glycol~2.1–3.1%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Acrylamide/sodium acryloyldimethyltaurate copolymer~1.7–2.5%
Formula
Irritation risk
Low

Helps water and oil mix together and create gel-like textures

More about Acrylamide/sodium acryloyldimethyltaurate copolymer
Cetearyl alcohol~1.4–2.1%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Glycine soja oil~1.2–1.8%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil
Isohexadecane~1.1–1.6%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Improves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent

More about Isohexadecane
Sodium hyaluronate~0.6–1.4%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Retinal palmitate
Not recognized
Adenosine~0.45–1.1%
Key active
Irritation risk
Low
Works for
Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine
Hydroxyethylpiperazine ethane sulfonic acid~0.4–0.9%
Irritant · medium
Irritation risk
Medium
Works for
Exfoliation

Used to regulate product's pH, but can be also used as an exfoliator when included in higher concentrations. There is a controversy about whether it can generate free radicals and induce skin cell damage when used in topical products

More about Hydroxyethylpiperazine ethane sulfonic acid
Caprylyl glycol~0.35–0.85%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Polysorbate 80~0.35–0.75%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Polysorbate 80
Phenoxyethanol~0.2–0.75%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Parfum~0.15–0.7%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Hydroxyethylpiperazine ethane sulfonic acid~0.15–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Exfoliation

Used to regulate product's pH, but can be also used as an exfoliator when included in higher concentrations. There is a controversy about whether it can generate free radicals and induce skin cell damage when used in topical products

More about Hydroxyethylpiperazine ethane sulfonic acid
Pentylene glycol~0.15–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Disodium edta~0.1–0.4%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Acetyl
Not recognized
Dipeptide-1~0.1–0.35%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Helps attract water to the upper layer of the skin and might have anti-aging benefits

More about Dipeptide-1
Cetyl ester
Not recognized
Toluene sulfonic acid~0.05–0.25%
Formula
Irritation risk
Low
Works for
Cleansing
More about Toluene sulfonic acid
Retinyl palmitate~0.05–0.1%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Tocopherol~0.05–0.15%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ingredient list view

Water, Isostearyl neopentanoate, Glycerin, Unknown, Propylene glycol, Pentylene glycol, Acrylamide/sodium acryloyldimethyltaurate copolymer, Cetearyl alcohol, Glycine soja oil, Isohexadecane, Sodium hyaluronate, Unknown, Adenosine, Hydroxyethylpiperazine ethane sulfonic acid, Caprylyl glycol, Polysorbate 80, Phenoxyethanol, Parfum, Hydroxyethylpiperazine ethane sulfonic acid, Pentylene glycol, Disodium edta, Unknown, Dipeptide-1, Unknown, Toluene sulfonic acid, Retinyl palmitate, Tocopherol

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Amazon USPrice as of 10/22/2026 03:15 GMT
$54.97
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
La Roche-PosayRedermic R Anti-Wrinkle Retinol Night CreamYOUR PRODUCTI'm fromRice CreamVichyNeovadiol Perimenopause Plumping Day Cream for Dry SkinAPLBIntensive Repair Horse Oil Cream
Match—60%59%59%
Price$48.25$29.27−$18.98$32.00−$16.25$24.00−$24.25
Shared key ingredients—3 of 64 of 64 of 6
Key difference—PhytosphingosineNiacinamideNiacinamide
Irritancy Medium Low Medium Medium
Drying alcohol—— Contains drying alcohol —
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La Roche-Posay Redermic R Anti-Wrinkle Retinol Night Cream
La Roche-PosayRedermic R Anti-Wrinkle Retinol Night Cream

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