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ISDIN ceutics Melatonik
ISDIN

ISDIN ceutics Melatonik

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Anti-aging
Bakuchiol, Melatonin + 4 more
Works well
What the product description says
“The 3-in-1 formula containing melatonin, bakuchiol and vitamin C stimulates natural antioxidant defenses and helps to restore vitality and elasticity, for radiant, healthy skin.”
Source: ISDIN

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains bakuchiol.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

BakuchiolKey activeEffect: HighA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation~1.7–2.6%
MelatoninEffect: LowA compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare~0.45–1.05%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.45%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.05–0.2%
Ascorbyl tetraisopalmitateUnder-dosedA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~4.4–6.6%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.05–0.15%
Anti-oxidation
Side benefit · Bakuchiol, Melatonin + 4 more
Works well

This product contains antioxidants (bakuchiol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - melatonin also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

BakuchiolKey activeEffect: HighA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation~1.7–2.6%
MelatoninKey activeEffect: MediumA compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare~0.45–1.05%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.05–0.2%
Ascorbyl tetraisopalmitateUnder-dosedA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~4.4–6.6%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.45%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.05–0.15%
Evens skin tone
Side benefit · Bakuchiol, Ascorbyl tetraisopalmitate + 1 more
Works well

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: bakuchiol

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

BakuchiolKey activeEffect: HighA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation~1.7–2.6%
Ascorbyl tetraisopalmitateUnder-dosedA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~4.4–6.6%
Ascorbic acidUnder-dosedThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~0.05–0.15%
Anti-blemish
Side benefit · Bakuchiol
May help

This product might be able to help reduce blemishes and clogged pores because it contains bakuchiol.

BakuchiolKey activeEffect: HighA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation~1.7–2.6%
Moisturizing
Side benefit · Caprylic/capric triglyceride, Squalane + 5 more
Works

This product can help soften the skin and reduce its moisture loss with emollients and occlusives: caprylic/capric triglyceride, squalane.

Keep in mind that this product does not contain effective ingredients to attract water to the upper layer of the skin. This is why an additional product with humectants like glycerin or hyaluronic acid can be helpful (apply it before this product for the best results).

Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~23–34%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~3.9–5.8%
Dicaprylyl carbonate· EmollientEffect: LowHelps products spread more easily and works as an emollient to soften skin~4.4–6.5%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~1.4–2%
Peg-8· HumectantEffect: LowUsed to create a nice product consistency~0.35–0.85%
Ascorbyl tetraisopalmitateEffect: Low, below effective doseA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)~4.4–6.6%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.45%

Can it cause trouble?

Irritancy
2 strong irritants: Alcohol denat., Parfum
Medium risk
We flagged 11 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Alcohol denat.Produces temporary toning effect. Can help dissolve other ingredients or preserve productsHigh~2.7–4%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.5–1.2%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~0.05–0.15%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~23–34%est.
Ascorbyl tetraisopalmitateA vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)Medium~4.4–6.6%est.
1,2-hexanediolA preservativeMedium~0.55–1.3%est.
BakuchiolA plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritationMedium~1.7–2.6%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~1.4–2%est.
Peg-8Used to create a nice product consistencyMedium~0.35–0.85%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.05–0.2%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.01–0.05%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged
Alternatives
The closest match we found
Bakuchiol Booster
Me Bakuchiol Booster
Closest match76% match
$12.02
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Ingredients

Filter by role to see what each ingredient is doing.

Caprylic/capric triglyceride~23–34%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Dicaprylyl carbonate~4.4–6.5%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps products spread more easily and works as an emollient to soften skin

More about Dicaprylyl carbonate
Ascorbyl tetraisopalmitate~4.4–6.6%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-agingEvens skin toneMoisturizing

A vitamin C derivative. Studies show that is might be effective in reducing hyperpigmentation, but there are no studies confirming that it is effectively converted into the bioavailable form of Vitamin C in skin. It is not clear how this derivative compares in effectiveness to the topical application of bioavailable form of vitamin C (L-ascorbic acid)

More about Ascorbyl tetraisopalmitate
Squalane~3.9–5.8%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Alcohol denat.~2.7–4%
Irritant · high
Irritation risk
High

Produces temporary toning effect. Can help dissolve other ingredients or preserve products

More about Alcohol denat.
1,2-hexanediol~0.55–1.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Bakuchiol~1.7–2.6%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-inflammatoryAnti-blemishEvens skin toneAnti-aging

A plant extract that is, though different in chemical structure, acts similar to retinoids. First studies show that it can help reduce fine lines and wrinkles, improve skin tone, reduce clogged pores and blemishes, and reduce inflammation. There is no conclusive evidence that bakuchiol is as effective as retinol however. The study that directly compared retinol with bakuchiol used bakuchiol applied twice daily compared to once per day for the retinol. According to this study, bakuchiol is less irritating than retinol. Bakuchiol is extracted from seeds of Babchi plant. Other parts of the plant contain coumarins that could cause allergic and irritant reactions. These compounds should be removed in the extraction process when bakuchiol is produced, but it is a good idea to be cautious and stay away from products that include the Babchi plant extracts other than purified bakuchiol to avoid irritation

More about Bakuchiol
Caprylyl glycol~1.4–2%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Parfum~0.5–1.2%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Melatonin~0.45–1.05%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-aging

A compound that can regulate sleep cycles in humans and animals. When used in cosmetics, comes from plant sources. It can work as anti-oxidant in skin when applied topically in skincare

More about Melatonin
Peg-8~0.35–0.85%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to create a nice product consistency

More about Peg-8
Water~0.15–0.65%
Formula
Irritation risk
Low

Plain old water

More about Water
Tocopherol~0.1–0.45%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Ascorbyl palmitate~0.05–0.2%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Ascorbic acid~0.05–0.15%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-aging

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Citric acid~0.01–0.05%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Caprylic/capric triglyceride, Dicaprylyl carbonate, Ascorbyl tetraisopalmitate, Squalane, Alcohol denat., 1,2-hexanediol, Bakuchiol, Caprylyl glycol, Parfum, Melatonin, Peg-8, Water, Tocopherol, Ascorbyl palmitate, Ascorbic acid, Citric acid

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ISDINceutics MelatonikYOUR PRODUCTMeBakuchiol BoosterEssanoWrinkle Rescue Retinol AlternativeSchafMoisturizer
Match—76%76%74%
Price—$12.02—$79.00
Shared key ingredients—3 of 53 of 53 of 5
Key difference—DimethiconeSunflower Seed OilNiacinamide
Irritancy Medium Low Low Low
Drying alcohol Contains drying alcohol ———
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Product summary

"ISDIN - ceutics Melatonik" is effective for: Evens skin tone and Anti-aging

This product could be helpful for: Anti-blemish and Moisturizing, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • This product also contains Vitamin C (Ascorbic Acid). It can be an effective active for anti-aging and evening out the skin tone, but in this product it is used for stabilizing other ingredients in the formulation. In this concentration (0.05% - 0.15%) it cannot have a noticeable benefit for the skin.
  • Bakuchiol in this product (the concentration is about 1.70% - 2.60%). Helps fight photodamage (wrinkles, elasticity loss and pigmentation) and can reduce clogged pores and blemishes. Bakuchiol is a compound extracted from a plant Babchi. It acts similar to retinoids, but with less irritation risk.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 11 studies and safety reviews.

  1. 1
    Assessment of penetration of Ascorbyl Tetraisopalmitate into biological membranes by molecular dynamicssciencedirect.com
  2. 2
    Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysisscielo.br
  3. 3
    A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative propertiessciencedirect.com
  4. 4
    New lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), suppresses senile lentigo through controlling of melanocytes-keratinocytes interactionmorressier.com
  5. 5
    The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
  6. 6
    Bakuchiol in the Management of Acne-affected Skinresearchgate.net
ISDIN ceutics Melatonik
ISDINceutics Melatonik
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