Works for:
based on ingredients and %- Anti-blemish
- Moisturizing
- Anti-aging
- Anti-oxidation
Doesn't work for:
based on ingredients and %- Evens skin tone
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 3
Key actives
Product Summary
"iS Clinical - Neck Perfect" has a good moisturizing formula. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Panthenol, glycerin, hyaluronic acid, sodium hyaluronate and glucose in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (dimethicone, cetearyl alcohol, cetyl alcohol, caprylyl glycol and glyceryl stearate) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- this moisturizer contains actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - madecassic acid 0.15% - 0.55%, asiatic acid 0.15% - 0.55% and asiaticoside 0.15% - 0.65% The Centella Asiatica actives, even in low concentration, can help reduce inflammation in skin, strengthen the skin barrier and reduce photodamage. They can also help to decrease scarring.
- This formulation also uses an effective concentration of panthenol (pro-vitamin B5) - about 4.10% - 6.20%. Panthenol helps strengthen the skin barrier, improve hydration and reduce inflammation in skin.
Irritation risk
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails for 71.38£ in the United Kingdom and for 105.00$ in the United States.
For a detailed price comparison: click here.
Works for
Does not work for
Anti-blemish
What does the product description say?
fights acne-causing bacteria to help keep your skin clear of blemishes iS Clinical offers clinically-proven skin care solutions and visible results.
Source: Dermstore
This product can help reduce breakouts and clogged pores because it contains the following ingredient: salicylic acid. This ingredient is used for treating acne and can have a noticeable effect.
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Anti-oxidation
This product contains antioxidants (asiaticoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
A plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking
A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals
Helps attract water to the upper layer of the skin. Might have some anti-oxidant properties
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect
Exfoliation
This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: salicylic acid.
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect
Moisturizing
What does the product description say?
Alpha Hydroxy Acids.
Source: Dermstore
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, hyaluronic acid.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, cetearyl alcohol.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: panthenol
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation
Sugar extract that helps attract water to the upper layer of the skin
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and madecassic acid) asiatic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Helps support skin barrier function improving skin hydration and reducing sensitivity
Red algae extract that helps attract water to the upper layer of the skin and create a nicer product consistency
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (asiaticoside, madecasosside and asiatic acid), madecassic acid has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Almond extract (oil) - helps soften the upper layer of the skin
Helps attract water to the upper layer of the skin. Might have some anti-oxidant properties
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function
Helps preserve products and creates a nice product texture
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Might help to attract water to the upper layer of the skin
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Anti-aging
What does the product description say?
You'll love iS Clinical's Neck Perfect, which helps care for mature skin by lifting and firming skin on your neck.
Source: Dermstore
This product contains asiaticoside. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
Evens skin tone
What does the product description say?
Designed with powerful alpha hydroxy acids and antioxidants, this product also diminishes the appearance of fine lines, free radical damage and dark spots.
Source: Dermstore
This product might help improve the skin tone through exfoliation. In other words, it helps to speed up the shedding of cells from the upper layer of the skin, and this might help reduce hyperpigmentation.
A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals
Used for skin exfoliation. It has an anti-inflammatory and anti-bacterial effect, helps to unclog pores, prevent blemishes and speed up healing of the existing ones. Sometimes referred to as a BHA (beta-hydroxy acid)
Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Moisturizing | |
| Anti-blemish | |
| Anti-aging | |
| Evens skin tone |
Total Promises Fulfilled score: 81/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 iS Clinical Neck Perfect | Current | $105.00 | |
Peter Thomas Roth Acne-Clear Oil-Free Matte Moisturizer | 64% | $38.00 | |
Colorescience Total Eye Firm Repair Cream | 61% | $98.00 | |
 PharmaClinix Acnex Cream | 60% | $14.00 | |
 La Roche-Posay Pure Vitamin C10 Anti-Aging Concentrate Cream | 59% | $56.00 | |
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Key Actives
Potential irritants
Comedogenic ingredients
All ingredients
Ingredient list view
Unknown, Hyaluronic acid, Salicylic acid, Panthenol, Unknown, Hyaluronic acid, Salicylic acid, Water, Sodium hyaluronate, Cetearyl alcohol, Ceteareth-20, Hydrolyzed quinoa, Vaccinium myrtillus fruit extract, Saccharum officinarum extract, Unknown, Decane, Hydrolyzed rice protein, Prunus amygdalus dulcis seed extract, Acacia senegal gum, Hydrolyzed rhizobian gum, Glycerin, Caprylic/capric triglyceride, Salix alba bark extract, Dimethicone, Cetyl alcohol, Glyceryl stearate, Calcium pantothenate, Citrus aurantium dulcis fruit extract, Citrus limon fruit extract, Acer saccharum extract, Asiaticoside, Asiatic acid, Madecassic acid, Salicylic acid, Glycyrrhiza glabra root extract, Citrus limon peel extract, Camellia sinensis leaf extract, Propylene glycol, Butylene glycol, Caprylyl glycol, 1,2-hexanediol, Phenoxyethanol, Chondrus crispus, Glucose, Peg-150 distearate, Disodium edta, Parfum, Polysorbate 20
- Efficacy of a New Topical Nano-hyaluronic Acid in Humans
- Physiochemical properties and application of hyaluronic acid: a systematic review
- Salicylic acid as a peeling agent: a comprehensive review
- Beta Hydroxy Acids
- A review of toxicity from topical salicylic acid preparations
- Glycolic Acid Peels Versus Salicylic–Mandelic Acid Peels in Active Acne Vulgaris and Post‐Acne Scarring and Hyperpigmentation: A Comparative Study
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Lonicera caerulea and Vaccinium myrtillus fruit polyphenols protect HaCaT keratinocytes against UVB-induced phototoxic stress and DNA damage
- Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.
- Protection Against Free Radicals (UVB Irradiation) of a Water-Soluble Enzymatic Extract from Rice Bran. Study Using Human Keratinocyte Monolayer and Reconstructed Human Epidermis
- Amended final report on the safety assessment of Oryza Sativa (rice) Bran Oil, Oryza Sativa (rice) Germ Oil, Rice Bran Acid,Oryza Sativa (rice) Bran Wax, Hydrogenated Rice Bran Wax, Oryza Sativa (rice)Bran Extract, Oryza Sativa (rice) Extract, Oryza Sativa (rice) Germ Powder, Oryza Sativa (rice) Starch, Oryza Sativa (rice) Bran, Hydrolyzed Rice Bran Extract, Hydrolyzed Rice Bran Protein, Hydrolyzed Rice Extract, and Hydrolyzed Rice Protein
- Glycerol and the skin: holistic approach to its origin and functions
- Efficacy and Safety of White Willow Bark (Salix alba) Extract
- An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging
- Dimethicone as a protective ingredient in topical medications
- Final Report on the Safety Assessment of Dimethicone Copolyol
- Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts
- Dexpanthenol Modulates Gene Expression in Skin Wound Healing in vivo
- Dexapanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation
- Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmetics
- Photosensitivity in children: An approach to diagnosis and management
- Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics
- Centella asiatica in cosmetology
- Contact dermatitis due to Madecassol
- Centella asiatica in Dermatology: An Overview
- Contact dermatitis due to Madecassol
- Centella asiatica in Dermatology: An Overview
- Surfactants and experimental irritant contact dermatitis
- Propylene Glycol
- Skin-sensitizing and irritant properties of propylene glycol
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Seaweeds as Source of Bioactive Substances and Skin Care Therapy—Cosmeceuticals, Algotheraphy, and Thalassotherapy
- Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Function