iS Clinical C & E Serum Advance+

iS Clinical C & E Serum Advance+

Efficacy91/100IrritancyMedium

Works for

Anti-aging
Ascorbic acid, Hyaluronic acid + 1 more
Works well
What the product description says
“Ideal for dull and wanting skin, it minimises the look of fine lines and wrinkles while combating UV and free radical damage.”
Source: Skinstore

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains ascorbic acid.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~3.6–5.4%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~1.9–2.9%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.8%
Evens skin tone
Ascorbic acid
Works well
What the product description says
“This powerful antioxidant formula combines a 15% Vitamin C with a 1% Vitamin E to improve skin tone and texture.”
Source: Skinstore

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: ascorbic acid.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~3.6–5.4%
Moisturizing
Hyaluronic acid, Propylene glycol + 1 more
Works
What the product description says
“Achieve a revitalised complexion with the iS Clinical C & E Serum Advance+ ; a water-based serum that balances botanical extracts with advanced scientific active ingredients to moisturise and nourish skin.”
Source: Skinstore

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": hyaluronic acid, propylene glycol.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

Hyaluronic acidKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~1.9–2.9%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~4.8–7.1%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.8%
Anti-oxidation
Not advertised by the brand · Ascorbic acid, Tocopherol
Works well

This product contains antioxidants (ascorbic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

Ascorbic acidHeroEffect: HighThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging~3.6–5.4%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.8%

Can it cause trouble?

Irritancy
1 strong irritant: Alcohol denat.
Medium risk
We flagged 5 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~4.8–7.1%est.
Ascorbic acidThe most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of agingHigh~3.6–5.4%est.
Alcohol denat.Produces temporary toning effect. Can help dissolve other ingredients or preserve productsHigh~2.7–4%est.
Zinc sulfateA preservative. It can be irritatingHigh~0.85–1.25%est.
Laureth-4Helps water and oil mix togetherMedium~1.2–1.8%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Laureth-4Helps water and oil mix together2/5~1.2–1.8%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Propylene glycol~4.8–7.1%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Ascorbic acid~3.6–5.4%
Hero · Anti-aging, Anti-oxidation, Evens skin toneIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-agingAnti-oxidation

The most well-researched antioxidant that works in skin. Helps neutralize free radicals supporting collagen production, helping to even out the skin tone and preventing early signs of aging

More about Ascorbic acid
Alcohol denat.~2.7–4%
Irritant · high
Irritation risk
High

Produces temporary toning effect. Can help dissolve other ingredients or preserve products

More about Alcohol denat.
Hyaluronic acid~1.9–2.9%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Laureth-4~1.2–1.8%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps water and oil mix together

More about Laureth-4
Zinc sulfate~0.85–1.25%
Irritant · high
Irritation risk
High

A preservative. It can be irritating

More about Zinc sulfate
Tocopherol~0.35–0.8%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Bioflavonoids~0.1–0.4%
Formula
Irritation risk
Low
More about Bioflavonoids
Phenoxyethanol~0.1–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ingredient list view

Water, Propylene glycol, Ascorbic acid, Alcohol denat., Hyaluronic acid, Laureth-4, Zinc sulfate, Tocopherol, Bioflavonoids, Phenoxyethanol

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Amazon USPrice as of 11/4 18:00 GMT
$177.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
iS ClinicalC & E Serum Advance+YOUR PRODUCTGoldfaden MDBrightening ElixirOARS + ALPSWake Up Face SerumReform SkincareVitamin C 20% Serum
Match—99%97%97%
Price$177.00$45.00−$132.00$49.00−$128.00—
Shared key ingredients—3 of 31 of 32 of 3
Key difference—NiacinamideBeta-GlucanFerulic Acid
Irritancy Medium Low Low Low
Drying alcohol Contains drying alcohol ———
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 9 studies and safety reviews.

  1. 1
  2. 2
    Propylene Glycolpubmed.ncbi.nlm.nih.gov
  3. 3
  4. 4
  5. 5
  6. 6
iS Clinical C & E Serum Advance+
iS ClinicalC & E Serum Advance+

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.