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Giovanni D:tox System Replenishing Facial Moisturizer - Step 3
Giovanni

Giovanni D:tox System Replenishing Facial Moisturizer - Step 3

Efficacy75/100IrritancyHigh
See all ingredients

Works for

Anti-aging
Retinyl palmitate, Aloe barbadensis leaf juice + 1 more
May help
What the product description says
“With green tea and fig antioxidants to help fight the damaging effects of free radicals and super antioxidants acai and goji berry to help recharge cells this moisturizer may be one of the most potent available to keep face looking and feeling youthful.”
Source: Walgreens

This product contains retinyl palmitate. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~1–1.5%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.1–0.35%
Lycium barbarum fruit extractEffect: Low, below effective doseA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.05–0.3%
Moisturizing
Glycerin, Cetyl alcohol + 11 more
Works
What the product description says
“D:tox System Replenishing Facial Moisturizer - Step 3”
Source: Walgreens

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: glycine soja oil, vitis vinifera seed oil.

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.3–6.4%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~3.2–4.8%
Glyceryl stearate seKey activeEffect: MediumUsed to stabilize the product formulations and works as an emollient~2.4–3.6%
Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~1.3–2%
Vitis vinifera seed oilKey active· EmollientEffect: HighA great emollient that can also have anti-oxidant properties~0.3–0.75%
Saccharum officinarum extractKey activeEffect: HighSugar extract that helps attract water to the upper layer of the skin~0.15–0.55%
Stearic acid· EmollientEffect: LowHelps oil and water mix together and works as an emollient~2.1–3.1%
Isopropyl palmitate· EmollientEffect: LowHelps soften the upper layer of the skin and create a thicker product consistency~1.6–2.4%
Lecithin· EmollientEffect: LowUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.45–1%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.1–0.35%
Simmondsia chinensis seed oilUnder-dosedSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~0.35–0.85%
Butyrospermum parkii butter extractUnder-dosedA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.3–0.75%
Lycium barbarum fruit extractUnder-dosedA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.05–0.3%
Anti-oxidation
Side benefit · Camellia sinensis extract, Ficus carica fruit extract + 5 more
May help

This product contains antioxidants (camellia sinensis extract, ficus carica fruit extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Camellia sinensis extractKey activeEffect: MediumTea extract. Might be helpful in neutralizing free radicals in skin~0.05–0.15%
Ficus carica fruit extractKey activeEffect: MediumA plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effect~0.05–0.2%
Tocopheryl acetateEffect: LowA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.~1.2–1.8%
Vitis vinifera seed oilEffect: LowA great emollient that can also have anti-oxidant properties~0.3–0.75%
Vaccinium myrtillus fruit extractEffect: LowA plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking~0.2–0.7%
Euterpe oleracea fruit extractEffect: LowA plant extract that can have some anti-oxidant effect in skin~0.1–0.3%
Lycium barbarum fruit extractUnder-dosedA plant extract that can help neutralize free radicals in skin and attract water to its upper layer~0.05–0.3%
Evens skin tone
Side benefit · Retinyl palmitate
May help

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: retinyl palmitate.

Retinyl palmitateKey activeEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~1–1.5%

Can it cause trouble?

Irritancy
4 strong irritants: Retinyl palmitate, Citrus aurantium dulcis fruit extract + 2 more — patch-test recommended
High risk
We flagged 17 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~1–1.5%est.
Citrus aurantium dulcis fruit extractA plant extract that is used as a fragrance. Can be irritating and lead to photosensitivityHigh~0.1–0.45%est.
Citrus limon fruit extractUsed as a fragrance. Can be irritating and cause photosensitivityHigh~0.1–0.4%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.01–0.1%est.
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistencyMedium~1.6–2.4%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~1.3–2%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~1.2–1.8%est.
Polysorbate 60Helps oil and water mix togetherMedium~0.5–1.15%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.35–0.8%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~0.35–0.85%est.
Vitis vinifera seed oilA great emollient that can also have anti-oxidant propertiesMedium~0.3–0.75%est.
Vaccinium myrtillus fruit extractA plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lackingMedium~0.2–0.7%est.
Acer saccharum extractA plant extract that contains small percentage of AHAs. Is unlikely to have any skin benefit due the small concentration of the active compoundsMedium~0.1–0.5%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.1–0.35%est.
Euterpe oleracea fruit extractA plant extract that can have some anti-oxidant effect in skinMedium~0.1–0.3%est.
Lycium barbarum fruit extractA plant extract that can help neutralize free radicals in skin and attract water to its upper layerMedium~0.05–0.3%est.
Ficus carica fruit extractA plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effectMedium~0.05–0.2%est.
Comedogenic
4 ingredients rated 2 or more on the 0–5 pore-clogging scale
4 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Isopropyl palmitateHelps soften the upper layer of the skin and create a thicker product consistency3/5~1.6–2.4%est.
Butyrospermum parkii butter extractA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.3–0.75%est.
Glyceryl stearate seUsed to stabilize the product formulations and works as an emollient2/5~2.4–3.6%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~1.3–2%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.3–6.4%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetyl alcohol~3.2–4.8%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Glyceryl stearate se~2.4–3.6%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

Used to stabilize the product formulations and works as an emollient

More about Glyceryl stearate se
Stearic acid~2.1–3.1%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Isopropyl palmitate~1.6–2.4%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
Moisturizing

Helps soften the upper layer of the skin and create a thicker product consistency

More about Isopropyl palmitate
Glycine soja oil~1.3–2%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil
Tocopheryl acetate~1.2–1.8%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Retinyl palmitate~1–1.5%
Key activeIrritant · high
Irritation risk
High
Works for
Evens skin toneAnti-blemishAnti-agingExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Phenoxyethanol~0.5–1%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Polysorbate 60~0.5–1.15%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Lecithin~0.45–1%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Citric acid~0.35–0.8%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Simmondsia chinensis seed oil~0.35–0.85%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Vitis vinifera seed oil~0.3–0.75%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

A great emollient that can also have anti-oxidant properties

More about Vitis vinifera seed oil
Butyrospermum parkii butter extract~0.3–0.75%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter extract
Vaccinium myrtillus fruit extract~0.2–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might help neutralize free radicals in skin, but research on its efficacy in skin is lacking

More about Vaccinium myrtillus fruit extract
Saccharum officinarum extract~0.15–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

Sugar extract that helps attract water to the upper layer of the skin

More about Saccharum officinarum extract
Acer saccharum extract~0.1–0.5%
Irritant · medium
Irritation risk
Medium

A plant extract that contains small percentage of AHAs. Is unlikely to have any skin benefit due the small concentration of the active compounds

More about Acer saccharum extract
Citrus aurantium dulcis fruit extract~0.1–0.45%
Irritant · high
Irritation risk
High

A plant extract that is used as a fragrance. Can be irritating and lead to photosensitivity

More about Citrus aurantium dulcis fruit extract
Citrus limon fruit extract~0.1–0.4%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating and cause photosensitivity

More about Citrus limon fruit extract
Aloe barbadensis leaf juice~0.1–0.35%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingReduces irritationAnti-inflammatoryReduces rednessAntibacterialAnti-agingAnti-blemish

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Euterpe oleracea fruit extract~0.1–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that can have some anti-oxidant effect in skin

More about Euterpe oleracea fruit extract
Lycium barbarum fruit extract~0.05–0.3%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationAnti-agingAnti-inflammatory

A plant extract that can help neutralize free radicals in skin and attract water to its upper layer

More about Lycium barbarum fruit extract
Ficus carica fruit extract~0.05–0.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that can help neutralize free radicals. The concentrations typically used in cosmetics are too small to have an effect

More about Ficus carica fruit extract
Camellia sinensis extract~0.05–0.15%
Key active
Irritation risk
Low
Works for
Anti-oxidation

Tea extract. Might be helpful in neutralizing free radicals in skin

More about Camellia sinensis extract
Parfum~0.01–0.1%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Ingredient list view

Water, Glycerin, Cetyl alcohol, Glyceryl stearate se, Stearic acid, Isopropyl palmitate, Glycine soja oil, Tocopheryl acetate, Retinyl palmitate, Phenoxyethanol, Polysorbate 60, Lecithin, Citric acid, Simmondsia chinensis seed oil, Vitis vinifera seed oil, Butyrospermum parkii butter extract, Vaccinium myrtillus fruit extract, Saccharum officinarum extract, Acer saccharum extract, Citrus aurantium dulcis fruit extract, Citrus limon fruit extract, Aloe barbadensis leaf juice, Euterpe oleracea fruit extract, Lycium barbarum fruit extract, Ficus carica fruit extract, Camellia sinensis extract, Parfum

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
GiovanniD:tox System Replenishing Facial Moisturizer - Step 3YOUR PRODUCTMILK MAKEUPVegan Milk MoisturizerDerma EAnti-Wrinkle Renewal CreamCommunity Sixty-SixOil Control Moisturizer with Niacinamide
Match—35%34%33%
Price—$17.56$19.13$12.47
Shared key ingredients—4 of 92 of 93 of 9
Key difference—Agran OilRetinolNiacinamide
Irritancy High Medium Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 12 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Final Report on the Safety Assessment of Isopropyl Isostearatejournals.sagepub.com
  3. 3
    Lonicera caerulea and Vaccinium myrtillus fruit polyphenols protect HaCaT keratinocytes against UVB-induced phototoxic stress and DNA damagesciencedirect.com
  4. 4
    Herbal Medicine: Biomolecular and Clinical Aspects. 2nd edition.ncbi.nlm.nih.gov
  5. 5
    Safety Assessment of Citrus Fruit-Derived Ingredients as Used in Cosmeticscir-safety.org
  6. 6
    Photosensitivity in children: An approach to diagnosis and managementijdvl.com
Giovanni D:tox System Replenishing Facial Moisturizer - Step 3
GiovanniD:tox System Replenishing Facial Moisturizer - Step 3
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As an Amazon Associate, WIMJ earns from qualifying purchases.