Epicuren Skin Rejuvenation Therapy Moisturizing Cream

Epicuren Skin Rejuvenation Therapy Moisturizing Cream

Efficacy87/100IrritancyHigh
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Works for

2 of 2 advertised claims delivered

Moisturizing
Sh-oligopeptide-1, Oenothera biennis oil + 16 more
Strong evidence
What the product description says
“Skin Rejuvenation Therapy Moisturizing Cream”
From product name

This product can help soften the skin and reduce its moisture loss with emollients and occlusives: caprylic/capric triglyceride, carthamus tinctorius seed oil.

Keep in mind that this product does not contain effective ingredients to attract water to the upper layer of the skin. This is why an additional product with humectants like glycerin or hyaluronic acid can be helpful (apply it before this product for the best results).

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: sh-oligopeptide-1

Oenothera biennis oilKey active· EmollientEffect: HighHelps soften the upper layer of the skin and can support skin barrier function~0.2–0.4%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~4.7–5.7%
Sesamum indicum seed oilKey active· EmollientEffect: HighA good moisturizing plant oil. Due to the high linoleic acid content, it helps soften the upper layer of the skin, reduce water loss and support skin barrier function~1.1–1.3%
Carthamus tinctorius seed oilKey active· EmollientEffect: HighAn emollient that helps soften the skin and might help calm down inflammation~5.7–7%
Collagen amino acidsKey activeEffect: HighHelp attract water to the upper layer of the skin, soften it and support the skin barrier function~1.9–2.3%
Cucurbita pepo seed oilKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.2–0.4%
Sh-oligopeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~0.95–1.15%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~3–3.7%
Aloe barbadensis leaf extract· Humectant, EmollientEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.4–1.7%
BiotinEffect: LowMight have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect~0.35–0.6%
Rosa damascena flower oilEffect: LowUsed as a fragrance. Can be irritating~0.25–0.5%
AllantoinUnder-dosedEffect: HighHelps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated~0.15–0.3%
NiacinUnder-dosedEffect: HighA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.3–0.6%
PanthenolUnder-dosedEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.1–0.2%
Prunus armeniaca kernel oilUnder-dosedEffect: HighAn emollient that helps soften the skin~0.2–0.4%
Simmondsia chinensis seed oilUnder-dosedEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~0.25–0.45%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.15–0.25%
Anti-aging
Sh-oligopeptide-1, Ascorbyl palmitate + 2 more
Moderate evidence
What the product description says
“This luxurious blend, hydrates the skin, while Epicuren ® ’s Metadermabolic ® Protein Enzyme Complex and Epidermal Growth Factor work to address the appearance of aging.”
Source: Epicuren

This product contains sh-oligopeptide-1. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Sh-oligopeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.3–0.55%
NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.3–0.6%
Retinyl palmitateUnder-dosedEffect: MediumThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect~0.2–0.35%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.2–0.35%

Can it cause trouble?

Irritancy
9 strong irritants: Citrus grandis seed extract, Rosa damascena flower oil + 7 more — patch-test recommended
High risk
We flagged 22 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Citrus grandis seed extract—High~0.55–0.85%est.
Chamomilla recutita extractPlant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritatingHigh~0.5–0.75%est.
NiacinA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effectHigh~0.3–0.6%est.
Rosa damascena flower oilUsed as a fragrance. Can be irritatingHigh~0.25–0.5%est.
Citrus aurantium amara flower oilUsed as a fragrance. Can be irritatingHigh~0.2–0.4%est.
Citrus aurantium dulcis oilUsed as a fragrance. It can be irritating and cause photosensitivityHigh~0.2–0.4%est.
Rose extractUsed as a fragrance. Can be irritatingHigh~0.2–0.35%est.
Lavandula angustifolia oilAn essential oil. Potential allergen and can be irritating. It has some anti-bacterial propertiesHigh~0.15–0.3%est.
Eucalyptus globulus leaf oilAn essential oil that can be very irritating. Has some anti-bacterial propertiesHigh~0.15–0.3%est.
Retinyl palmitateThree steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effectHigh~0.2–0.35%est.
Santalum album oilUsed as a fragrance. Can be irritatingHigh~0.15–0.3%est.
Citrus aurantium dulcis peel oilAn essentil oil from orange peel. Potential allergen and can be irritatingHigh~0.15–0.25%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~4.7–5.7%est.
Tocopheryl acetateA more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.Medium~2.2–2.7%est.
Aloe barbadensis leaf extractTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~1.4–1.7%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~0.25–0.45%est.
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.2–0.35%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.2–0.35%est.
Ceteareth-20Helps oil and water mix together. Has some emollient propertiesMedium~0.3–0.55%est.
Prunus armeniaca kernel oilAn emollient that helps soften the skinMedium~0.2–0.4%est.
Oenothera biennis oilHelps soften the upper layer of the skin and can support skin barrier functionMedium~0.2–0.4%est.
EthylhexylglycerinA preservativeMedium~0.1–0.2%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~0.95–1.15%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~3–3.7%est.
Ceteareth-20Helps oil and water mix together. Has some emollient properties2/5~0.3–0.55%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Carthamus tinctorius seed oil~5.7–7%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

An emollient that helps soften the skin and might help calm down inflammation

More about Carthamus tinctorius seed oil
Caprylic/capric triglyceride~4.7–5.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Cetearyl alcohol~3–3.7%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Tocopheryl acetate~2.2–2.7%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.

More about Tocopheryl acetate
Hydrolyzed
Not recognized
Collagen amino acids~1.9–2.3%
Key active
Irritation risk
Low
Works for
Moisturizing

Help attract water to the upper layer of the skin, soften it and support the skin barrier function

More about Collagen amino acids
Hydrolyzed
Not recognized
Elastin amino acids~1.6–2%
Formula
Aloe barbadensis leaf extract~1.4–1.7%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf extract
Sesamum indicum seed oil~1.1–1.3%
Key active
Irritation risk
Low
Works for
Moisturizing

A good moisturizing plant oil. Due to the high linoleic acid content, it helps soften the upper layer of the skin, reduce water loss and support skin barrier function

More about Sesamum indicum seed oil
Ethylhexyl palmitate~0.95–1.15%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Citrus grandis seed extract~0.55–0.85%
Irritant · high
Chamomilla recutita extract~0.5–0.75%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatory

Plant extract that can have healing and anti-inflammatory properties. It is a potential allergen and can be irritating

More about Chamomilla recutita extract
Arctostaphylos uva ursi leaf extract~0.45–0.65%
Formula
Biotin~0.35–0.6%
Formula
Irritation risk
Low
Works for
Moisturizing

Might have some moisturising properties. Is not effective when applied topically beyond some moisturizing effect

More about Biotin
Niacin~0.3–0.6%
Under-dosedIrritant · high
Irritation risk
High
Works for
MoisturizingAnti-agingAnti-blemishEvens skin tone

A form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect

More about Niacin
Riboflavin~0.3–0.55%
Formula
Irritation risk
Low
More about Riboflavin
Sh-oligopeptide-1~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Sh-oligopeptide-1
Rosa damascena flower oil~0.25–0.5%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Used as a fragrance. Can be irritating

More about Rosa damascena flower oil
Vetiveria zizanoides root oil~0.2–0.4%
Formula
Citrus aurantium amara flower oil~0.2–0.4%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating

More about Citrus aurantium amara flower oil
Citrus aurantium dulcis oil~0.2–0.4%
Irritant · high
Irritation risk
High

Used as a fragrance. It can be irritating and cause photosensitivity

More about Citrus aurantium dulcis oil
Rose extract~0.2–0.35%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating

More about Rose extract
Jasminum officinale oil~0.1–0.2%
Formula
Lavandula angustifolia oil~0.15–0.3%
Irritant · high
Irritation risk
High

An essential oil. Potential allergen and can be irritating. It has some anti-bacterial properties

More about Lavandula angustifolia oil
Simmondsia chinensis seed oil~0.25–0.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Cucurbita pepo seed oil~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Cucurbita pepo seed oil
Eucalyptus globulus leaf oil~0.15–0.3%
Irritant · high
Irritation risk
High
Works for
Antibacterial

An essential oil that can be very irritating. Has some anti-bacterial properties

More about Eucalyptus globulus leaf oil
Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer
Allantoin~0.15–0.3%
Under-dosed
Irritation risk
Low
Works for
Anti-inflammatoryMoisturizingReduces irritationAnti-blemishReduces rednessExfoliation

Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated

More about Allantoin
Ascorbyl palmitate~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationAnti-aging

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Ceteareth-20~0.3–0.55%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together. Has some emollient properties

More about Ceteareth-20
Sorbitan stearate~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Sorbitan stearate
Retinyl palmitate~0.2–0.35%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneAnti-blemishExfoliation

Three steps removed from the active form of vitamin A - retinoic acid. To have an effect in the skin, it first needs to be converted twice to become the retinoic acid. This means it is less potent than retinol, but could also be less irritating. Once converted to the retinoic acid in the skin, it helps against all signs of aging, improves skin cell turnover and helps fight blemishes and clogged pores. However, in many cosmetic formulations, it is used in a concentration that is too low to have the full effect

More about Retinyl palmitate
Prunus armeniaca kernel oil~0.2–0.4%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

An emollient that helps soften the skin

More about Prunus armeniaca kernel oil
Daucus carota sativa seed oil~0.25–0.4%
Formula
Irritation risk
Low
Works for
Anti-oxidationAntibacterial

A plant oil that might help neutralize free radicals and have an anti-bacterial effect

More about Daucus carota sativa seed oil
Oenothera biennis oil~0.2–0.4%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidationAnti-blemishAnti-inflammatory

Helps soften the upper layer of the skin and can support skin barrier function

More about Oenothera biennis oil
Santalum album oil~0.15–0.3%
Irritant · high
Irritation risk
High

Used as a fragrance. Can be irritating

More about Santalum album oil
Citrus aurantium dulcis peel oil~0.15–0.25%
Irritant · high
Irritation risk
High

An essentil oil from orange peel. Potential allergen and can be irritating

More about Citrus aurantium dulcis peel oil
Panthenol~0.1–0.2%
Under-dosed
Irritation risk
Low
Works for
Reduces rednessMoisturizingReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Lecithin~0.15–0.25%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Propanediol~0.15–0.25%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Phenoxyethanol~0.15–0.3%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ethylhexylglycerin~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Ingredient list view

Water, Carthamus tinctorius seed oil, Caprylic/capric triglyceride, Cetearyl alcohol, Tocopheryl acetate, Unknown, Collagen amino acids, Unknown, Elastin amino acids, Aloe barbadensis leaf extract, Sesamum indicum seed oil, Ethylhexyl palmitate, Citrus grandis seed extract, Chamomilla recutita extract, Arctostaphylos uva ursi leaf extract, Biotin, Niacin, Riboflavin, Sh-oligopeptide-1, Rosa damascena flower oil, Vetiveria zizanoides root oil, Citrus aurantium amara flower oil, Citrus aurantium dulcis oil, Rose extract, Jasminum officinale oil, Lavandula angustifolia oil, Simmondsia chinensis seed oil, Cucurbita pepo seed oil, Eucalyptus globulus leaf oil, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Allantoin, Ascorbyl palmitate, Ceteareth-20, Sorbitan stearate, Retinyl palmitate, Prunus armeniaca kernel oil, Daucus carota sativa seed oil, Oenothera biennis oil, Santalum album oil, Citrus aurantium dulcis peel oil, Panthenol, Lecithin, Propanediol, Phenoxyethanol, Ethylhexylglycerin

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Epicuren
$80.00
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Amazon USPrice as of 10/21/2026 06:28 GMT
$88.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
EpicurenSkin Rejuvenation Therapy Moisturizing CreamYOUR PRODUCTTOSOWOONGCica Snail CreamSaturday SkinMulti Peptide Repair Treatment CreamOrjenaResponse synergy barrier cream
Match—56%56%54%
Price$80.00$16.40−$63.60$24.90−$55.10$25.00−$55.00
Shared key ingredients—4 of 133 of 133 of 13
Key difference—Copper Tripeptide-1Sh-Polypeptide-45Niacinamide
Irritancy High Medium Medium Low
Drying alcohol————
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Product summary

"Epicuren - Skin Rejuvenation Therapy Moisturizing Cream" is a well-rounded moisturizing product. This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Aloe barbadensis leaf extract in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Carthamus tinctorius seed oil, cucurbita pepo seed oil, oenothera biennis oil, sesamum indicum seed oil and caprylic/capric triglyceride in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • this moisturizer includes a form of retinoids (vitamin A) - retinyl palmitate 0.20% - 0.35%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • This moistruizer also contains peptides (sh-oligopeptide-1 0.30% - 0.55%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.

Irritation risk

This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails for 80.00$ in the United States, for 130.72A$ in Australia and for 234.80£ in the United Kingdom.

For a detailed price comparison: click here.

Epicuren Skin Rejuvenation Therapy Moisturizing Cream
EpicurenSkin Rejuvenation Therapy Moisturizing Cream

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.