Dermactin Upper Eyelid Cream

Dermactin Upper Eyelid Cream

Efficacy75/100IrritancyLow
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Works for

1 of 1 advertised claim delivered

Anti-aging
Palmitoyl oligopeptide, Palmitoyl tetrapeptide-7 + 2 more
Moderate evidence
What the product description says
“Specially formulated for the sensitive skin on and around the eyelids, this product will help firm and tone sagging and drooping skin on the upper eyelids.”
Source: Amazon CA

This product contains palmitoyl oligopeptide, palmitoyl tetrapeptide-7. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl oligopeptideKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.25%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~2–2.5%
Prunus amygdalus dulcis oilEffect: LowAn emollient that softens the skin~0.25–0.5%
Moisturizing
Not advertised by the brand · Palmitoyl tetrapeptide-7, Palmitoyl oligopeptide + 19 more
Strong evidence

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium chondroitin sulfate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl oligopeptide, palmitoyl tetrapeptide-7

Sodium chondroitin sulfateKey active· HumectantEffect: HighIs naturally present in skin. Helps to attract water to its upper layer~0.2–0.4%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~0.65–0.95%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4–4.9%
Theobroma cacao seed butterKey active· EmollientEffect: HighHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect~1.2–1.5%
Persea gratissima oilKey active· EmollientEffect: HighAn emollient that helps soften the skin and could be helpful in repairing its barrier function~1–1.2%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~2–2.5%
Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.25%
Palmitoyl oligopeptideHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.25–0.45%
Secale cereale seed extractKey activeEffect: HighRye seed extract. Helps soften the upper layer of the skin~0.3–0.6%
Prunus amygdalus dulcis oilKey active· EmollientEffect: MediumAn emollient that softens the skin~0.25–0.5%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~2.5–3.1%
CyclopentasiloxaneKey active· EmollientEffect: MediumA silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin~2.4–2.9%
Hydrogenated vegetable oilKey active· EmollientEffect: MediumAn oil from a mixture of different vegetables. Helps soften the upper layer of the skin~0.7–1.1%
Hydrolyzed soy proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.25–0.45%
IsododecaneKey active· Emollient, OcclusiveEffect: MediumAn emollient that helps soften the skin and can decrease moisture loss. Helps create a nice product texture~6.6–8.1%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.45–0.7%
C13-14 isoparaffin· EmollientEffect: LowHelps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency~0.35–0.6%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.55–0.85%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.2–0.35%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.25–0.45%
Yeast extractUnder-dosedEffect: HighHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.2–0.4%
Evens skin tone
Not advertised by the brand · Phenylethyl resorcinol, Hydrolyzed soy protein + 1 more
Moderate evidence

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually works: phenylethyl resorcinol.

Phenylethyl resorcinolKey activeEffect: MediumMight help reduce hyperpigmentation in skin and help neutralize free radicals~0.25–0.5%
Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.25–0.45%
Yeast extractEffect: Low, below effective doseHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.2–0.4%

Can it cause trouble?

Irritancy
11 flagged ingredients
Low risk
We flag 11 ingredients with irritancy potential; the product's overall irritancy is low. The table lists each ingredient's own rating.
IngredientFunctionIrritationEst. amount
Phenylethyl resorcinolMight help reduce hyperpigmentation in skin and help neutralize free radicalsHigh~0.25–0.5%est.
Polysorbate 60Helps oil and water mix togetherMedium~1.5–1.8%est.
Persea gratissima oilAn emollient that helps soften the skin and could be helpful in repairing its barrier functionMedium~1–1.2%est.
PolyacrylamideUsed to improve product texture and help oil and water mix togetherMedium~0.45–0.7%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.45–0.7%est.
TriethanolamineUsed to adjust pH of the product and can help improve the product's smellMedium~0.4–0.6%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.25–0.5%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.25–0.45%est.
Laureth-7Helps oil and water mix togetherMedium~0.25–0.5%est.
Secale cereale seed extractRye seed extract. Helps soften the upper layer of the skinMedium~0.3–0.6%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.2–0.35%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~2–2.5%est.
Theobroma cacao seed butterHelps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect3/5~1.2–1.5%est.
Hydrogenated vegetable oilAn oil from a mixture of different vegetables. Helps soften the upper layer of the skin2/5~0.7–1.1%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Isododecane~6.6–8.1%
Key active
Irritation risk
Low
Works for
Moisturizing

An emollient that helps soften the skin and can decrease moisture loss. Helps create a nice product texture

More about Isododecane
Glycerin~4–4.9%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetyl alcohol~2.5–3.1%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Cyclopentasiloxane~2.4–2.9%
Key active
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that helps improve the product texture and spreadability. Can absorb oil creating a short-term mattifying effect on the skin

More about Cyclopentasiloxane
Butyrospermum parkii butter~2–2.5%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Peg-100 stearate~1.7–2.1%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix togehter and creates a nice product texture

More about Peg-100 stearate
Polysorbate 60~1.5–1.8%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 60
Theobroma cacao seed butter~1.2–1.5%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-dandruff

Helps soften the upper layer of the skin and can be helpful in restoring the skin barrier function. Might have some anti-oxidant effect

More about Theobroma cacao seed butter
Persea gratissima oil~1–1.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

An emollient that helps soften the skin and could be helpful in repairing its barrier function

More about Persea gratissima oil
Hydrogenated vegetable oil~0.7–1.1%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
Moisturizing

An oil from a mixture of different vegetables. Helps soften the upper layer of the skin

More about Hydrogenated vegetable oil
Dimethicone~0.65–0.95%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Glyceryl stearate~0.55–0.85%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Silica~0.75–1.1%
Formula
Irritation risk
Low

Used to absorb oil and can temporarily mattify skin

More about Silica
Polyacrylamide~0.45–0.7%
Irritant · medium
Irritation risk
Medium

Used to improve product texture and help oil and water mix together

More about Polyacrylamide
Caprylyl glycol~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Tridecyl salicylate~0.4–0.6%
Formula
Triethanolamine~0.4–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to adjust pH of the product and can help improve the product's smell

More about Triethanolamine
Phenoxyethanol~0.3–0.6%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
C13-14 isoparaffin~0.35–0.6%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin, dissolve other ingredients and create a thicker product consistency

More about C13-14 isoparaffin
Citric acid~0.25–0.5%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Xanthan gum~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Phenylethyl resorcinol~0.25–0.5%
Key activeIrritant · high
Irritation risk
High
Works for
Evens skin tone

Might help reduce hyperpigmentation in skin and help neutralize free radicals

More about Phenylethyl resorcinol
Hexylene glycol~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Laureth-7~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Laureth-7
Hydrolyzed soy protein~0.25–0.45%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin toneAnti-oxidationAnti-inflammatory

Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing

More about Hydrolyzed soy protein
Butylene glycol~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Prunus amygdalus dulcis oil~0.25–0.5%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-oxidationAnti-aging

An emollient that softens the skin

More about Prunus amygdalus dulcis oil
3-aminopropane sulfonic acid~0.25–0.4%
Formula
Irritation risk
Low
Works for
Cleansing
More about 3-aminopropane sulfonic acid
Secale cereale seed extract~0.3–0.6%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Rye seed extract. Helps soften the upper layer of the skin

More about Secale cereale seed extract
Yeast extract~0.2–0.4%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-oxidationReduces irritationAnti-inflammatoryEvens skin tone

Helps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin

More about Yeast extract
Sodium chondroitin sulfate~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Is naturally present in skin. Helps to attract water to its upper layer

More about Sodium chondroitin sulfate
Carbomer~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Polysorbate 20~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Palmitoyl oligopeptide~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingCleansingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl oligopeptide
Pentylene glycol~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Palmitoyl tetrapeptide-7~0.15–0.25%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7
Calcium hydroxymethionine~0.1–0.15%
Formula
Hydroxyethylcellulose~0.05–0.15%
Formula
Irritation risk
Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose
Ingredient list view

Water, Isododecane, Glycerin, Cetyl alcohol, Cyclopentasiloxane, Butyrospermum parkii butter, Peg-100 stearate, Polysorbate 60, Theobroma cacao seed butter, Persea gratissima oil, Hydrogenated vegetable oil, Dimethicone, Glyceryl stearate, Silica, Polyacrylamide, Caprylyl glycol, Tridecyl salicylate, Triethanolamine, Phenoxyethanol, C13-14 isoparaffin, Citric acid, Xanthan gum, Phenylethyl resorcinol, Hexylene glycol, Laureth-7, Hydrolyzed soy protein, Butylene glycol, Prunus amygdalus dulcis oil, 3-aminopropane sulfonic acid, Secale cereale seed extract, Yeast extract, Sodium chondroitin sulfate, Carbomer, Polysorbate 20, Palmitoyl oligopeptide, Pentylene glycol, Palmitoyl tetrapeptide-7, Calcium hydroxymethionine, Hydroxyethylcellulose

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Amazon USPrice as of 10/21/2026 12:14 GMT
$10.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
DermactinUpper Eyelid CreamYOUR PRODUCTNEOSTRATASkin Active Intensive Eye Therapy Firming Cream for Mature SkinSkinMedicaTNS Illuminating Eye Cream
Match—53%50%
Price$10.00$86.00+$76.00$82.80+$72.80
Shared key ingredients—5 of 124 of 12
Key difference—Acetyl GlucosaminePanthenol
Irritancy Low Low Low
Drying alcohol———
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Product summary

Judging from the ingredient list, "Dermactin - Upper Eyelid Cream" works well for improving skin hydration As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Glycerin, sodium chondroitin sulfate, hydrolyzed soy protein, butylene glycol and caprylyl glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Palmitoyl tetrapeptide-7, persea gratissima oil, theobroma cacao seed butter, butyrospermum parkii butter and dimethicone in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • We like that this moisturizer contains peptides (palmitoyl tetrapeptide-7 0.15% - 0.25% and palmitoyl oligopeptide 0.25% - 0.45%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: yeast extract

Irritation risk

This moisturizer contains actives that can be irritating. We assess the overall irritancy of this moisturizer to be low. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

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As an Amazon Associate, WIMJ earns from qualifying purchases.