CosMedix Cell ID Nutritive Defense Serum

CosMedix Cell ID Nutritive Defense Serum

Efficacy58/100IrritancyLow

Works for

Moisturizing
Panthenol, Palmitoyl tripeptide-5 + 8 more
Works well
What the product description says
“Helps support the skin’s protective barrier to lock-in long-lasting moisture”
Source: Cosmedix

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": glycerin, sodium hyaluronate.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tripeptide-5, panthenol

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~1.3–2%
Palmitoyl tripeptide-5HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.75%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.7–5.6%
Hydrolyzed wheat proteinKey active· HumectantEffect: MediumCan help attract water to the upper layer of the skin. Avoid if sensitive to gluten~1.2–1.7%
GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.6–1.4%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.45–1.1%
Hydrolyzed soy proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.35–0.8%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~2.1–3.1%
Calcium gluconate· HumectantEffect: LowHelps attract water to the upper layer of the skin and helps to improve appearance of the product~0.05–0.15%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.1–0.45%
Anti-aging
Palmitoyl tripeptide-5, Sodium salicylate + 1 more
May help
What the product description says
“Cell ID is a restorative Plant-Based Growth Factor serum that helps reduce the appearance of visible signs of aging, like fine lines and wrinkles and hyperpigmentation, and strengthens compromised skin barriers.”
Source: Cosmedix

This product contains palmitoyl tripeptide-5. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl tripeptide-5Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.2–0.75%
Sodium salicylateEffect: LowThe salt of salicylic acid. Helps exfoliate the upper layer of the skin. Can also work to preserve cosmetic products~0.25–0.5%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.1–0.45%
Evens skin tone
Hydrolyzed soy protein, Gluconolactone
Not delivered
What the product description says
“Cell ID is a restorative Plant-Based Growth Factor serum that helps reduce the appearance of visible signs of aging, like fine lines and wrinkles and hyperpigmentation, and strengthens compromised skin barriers.”
Source: Cosmedix

Effective ingredients missing or their concentration is too low

Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.35–0.8%
GluconolactoneUnder-dosedA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~0.1–0.45%

Can it cause trouble?

Irritancy
10 flagged ingredients
Low risk
We flag 10 ingredients with irritancy potential; the product's overall irritancy is low. The table lists each ingredient's own rating.
IngredientFunctionIrritationEst. amount
Phenethyl alcoholA fragrance. Can be irritatingHigh~0.4–0.95%est.
Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.05–0.15%est.
CarrageenanHelps thicken the product formula and create a nice product formulationMedium~3.7–5.5%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~2.1–3.1%est.
Hydrolyzed wheat proteinCan help attract water to the upper layer of the skin. Avoid if sensitive to glutenMedium~1.2–1.7%est.
Disodium edtaStabilizes the product formulationMedium~0.3–0.75%est.
Sodium salicylateThe salt of salicylic acid. Helps exfoliate the upper layer of the skin. Can also work to preserve cosmetic productsMedium~0.25–0.5%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~0.1–0.45%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.1–0.3%est.
Potassium sorbateA preservativeMedium~0.05–0.25%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
CarrageenanHelps thicken the product formula and create a nice product formulation3/5~3.7–5.5%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~3.7–5.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Carrageenan~3.7–5.5%
Comedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5

Helps thicken the product formula and create a nice product formulation

More about Carrageenan
Propanediol~2.6–4%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Pentylene glycol~2.1–3.1%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Pseudoalteromonas ferment extract~1.6–2.4%
Formula
Panthenol~1.3–2%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingReduces rednessReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol
Hydrolyzed wheat protein~1.2–1.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten

More about Hydrolyzed wheat protein
Calanthe discolor extract~0.95–1.45%
Formula
Glucose~0.6–1.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose
Sodium hyaluronate~0.45–1.1%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Phenethyl alcohol~0.4–0.95%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Phenethyl alcohol
Hydrolyzed soy protein~0.35–0.8%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin toneAnti-oxidationAnti-inflammatory

Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing

More about Hydrolyzed soy protein
Disodium edta~0.3–0.75%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Palmitoyl tripeptide-5~0.2–0.75%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-5
Sodium benzoate~0.25–0.5%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Sodium salicylate~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Anti-aging

The salt of salicylic acid. Helps exfoliate the upper layer of the skin. Can also work to preserve cosmetic products

More about Sodium salicylate
Xanthan gum~0.15–0.55%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Gluconolactone~0.1–0.45%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
ExfoliationMoisturizingAnti-agingEvens skin toneAnti-blemishAnti-oxidation

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Khaya senegalensis bark extract~0.1–0.4%
Formula
Maltodextrin~0.1–0.4%
Formula
Irritation risk
Low
Works for
Mattifying

Used to stabilize the product formulation and can help absorb oil

More about Maltodextrin
Citric acid~0.1–0.3%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Benzyl alcohol~0.05–0.15%
Irritant · high
Irritation risk
High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol
Potassium sorbate~0.05–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Acetyl tetrapeptide-22~0.05–0.2%
Formula
Acetylarginyltryptophyl diphenylglycine~0.05–0.1%
Formula
Calcium gluconate~0.05–0.15%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and helps to improve appearance of the product

More about Calcium gluconate
Ingredient list view

Water, Glycerin, Carrageenan, Propanediol, Pentylene glycol, Pseudoalteromonas ferment extract, Panthenol, Hydrolyzed wheat protein, Calanthe discolor extract, Glucose, Sodium hyaluronate, Phenethyl alcohol, Hydrolyzed soy protein, Disodium edta, Palmitoyl tripeptide-5, Sodium benzoate, Sodium salicylate, Xanthan gum, Gluconolactone, Khaya senegalensis bark extract, Maltodextrin, Citric acid, Benzyl alcohol, Potassium sorbate, Acetyl tetrapeptide-22, Acetylarginyltryptophyl diphenylglycine, Calcium gluconate

Compare prices

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Amazon USPrice as of 11/4 21:00 GMT
$128.00
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Cosmedix
$128.00
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
CosMedixCell ID Nutritive Defense SerumYOUR PRODUCTLuzern LaboratoriesLuzern WE3 Triple Action Serum Wrinkle CorrectorBIODANCEPore tightening collagen ampouleMedik8Liquid Peptides
Match—62%61%59%
Price$128.00—$35.04−$92.96$68.00−$60.00
Shared key ingredients—4 of 44 of 44 of 4
Key difference—NiacinamideNiacinamideCopper Palmitoyl Heptapeptide-14
Irritancy Low Low Low Low
Drying alcohol————
View product Shop Shop Shop

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 23 studies and safety reviews.

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CosMedix Cell ID Nutritive Defense Serum
CosMedixCell ID Nutritive Defense Serum

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

As an Amazon Associate, WIMJ earns from qualifying purchases.