Cliniderm Hydra Defense Gel

Cliniderm Hydra Defense Gel

Efficacy100/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Moisturizing
18 ingredients credited for this claim
Strong support
What the product description says
“Hydra Defense Gel”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, hyaluronic acid.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: sphingolipids, isodecyl neopentanoate.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: urea

GlycerinKey activeEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~5.3–6.5%
SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.45–0.7%
Sodium hyaluronateKey activeEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~1.3–1.6%
Sodium pcaKey activeEffect: HighNaturally present in skin and helps to attract water to its upper layer~3.2–3.9%
SphingolipidsKey activeEffect: HighSphingolipids are a group of lipids with a common chemical structure. Some of them are naturally present in skin and can be converted to ceramides~0.65–0.95%
TrehaloseKey activeEffect: HighA sugar that attracts water to the upper layer of the skin~0.5–0.7%
UreaHeroEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~4.4–5.3%
Lactococcus ferment lysateKey activeEffect: HighConsists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin~0.2–0.35%
Hyaluronic acidKey activeEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.6–0.85%
HoneyKey activeEffect: MediumHelps attract water to the skin and might have some anti-bacterial properties. Can be an allergen~0.95–1.15%
PhospholipidsKey activeEffect: MediumEmollients that are naturaly present in skin. In addition, they help water and oil mix together in the product~0.7–1.05%
Pentylene glycolEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.5–0.75%
Caprylyl glycolEffect: LowHelps preserve products and creates a nice product texture~0.35–0.65%
Dicaprylyl carbonateEffect: LowHelps products spread more easily and works as an emollient to soften skin~0.1–0.15%
Hydrogenated polydeceneEffect: LowHelps to soften the upper layer of the skin and create a nice product texture~0.15–0.3%
Isodecyl neopentanoateEffect: LowAn emollient that helps soften the skin. It also forms a protective on its surface to reduce water loss.~1.3–1.5%
AlginEffect: LowUsed to thicken product formulation. Can help attract water to the upper layer of the skin~0.4–0.65%
Polyquaternium-51Effect: LowAn emollient that helps create a nice silky finish on the skin~2.1–2.5%
Anti-aging
Not advertised by the brand · 2 ingredients credited for this claim
Moderate support

This product contains serine. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.45–0.7%
Hyaluronic acidEffect: LowOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation~0.6–0.85%

Can it cause trouble?

Irritancy
9 flagged ingredients
Medium risk
We flagged 9 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
TriacetinUsed to dissolve other ingredientsHigh~1.7–2%est.
PullulanCreates a thin drying film on the skin resulting in a short-term tightening effectHigh~0.25–0.45%est.
Ethylene brassylateA fragrance. Can be irritatingHigh~0.01–0.05%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.5–0.75%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.35–0.65%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.2–0.35%est.
Benzoic acidA preservativeMedium~0.01–0.05%est.
Dehydroacetic acidA preservativeMedium~0.01–0.05%est.
Polyglyceryl-3 caprateHelps oil and water mix togetherMedium~0.05–0.15%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
AlginUsed to thicken product formulation. Can help attract water to the upper layer of the skin3/5~0.4–0.65%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~5.3–6.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Urea~4.4–5.3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Sodium pca~3.2–3.9%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Trehalose~2.6–3.1%
Key active
Irritation risk
Low
Works for
Moisturizing

A sugar that attracts water to the upper layer of the skin

More about Trehalose
Polyquaternium-51~2.1–2.5%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps create a nice silky finish on the skin

More about Polyquaternium-51
Triacetin~1.7–2%
Irritant · high
Irritation risk
High

Used to dissolve other ingredients

More about Triacetin
Sodium hyaluronate~1.3–1.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Isodecyl neopentanoate~1.3–1.5%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps soften the skin. It also forms a protective on its surface to reduce water loss.

More about Isodecyl neopentanoate
Honey~0.95–1.15%
Key active
Irritation risk
Low
Works for
MoisturizingAntibacterial

Helps attract water to the skin and might have some anti-bacterial properties. Can be an allergen

More about Honey
Phospholipids~0.7–1.05%
Key active
Irritation risk
Low
Works for
Moisturizing

Emollients that are naturaly present in skin. In addition, they help water and oil mix together in the product

More about Phospholipids
Sphingolipids~0.65–0.95%
Key active
Irritation risk
Low
Works for
Moisturizing

Sphingolipids are a group of lipids with a common chemical structure. Some of them are naturally present in skin and can be converted to ceramides

More about Sphingolipids
Hyaluronic acid~0.6–0.85%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-aging

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin. Naturally present in skin. Typically has large molecule size unless advertised otherwise on the product label. Helps support skin's barrier function and may help to reduce inflammation

More about Hyaluronic acid
Glyceryl polyacrylate~0.55–0.85%
Formula
Irritation risk
Low

Helps to create a nice product texture and spread the product more easily on the skin

More about Glyceryl polyacrylate
Trehalose~0.5–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

A sugar that attracts water to the upper layer of the skin

More about Trehalose
Serine~0.45–0.7%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine
Pentylene glycol~0.5–0.75%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Algin~0.4–0.65%
Comedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

Used to thicken product formulation. Can help attract water to the upper layer of the skin

More about Algin
Caprylyl glycol~0.35–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Pullulan~0.25–0.45%
Irritant · high
Irritation risk
High
Works for
Mattifying

Creates a thin drying film on the skin resulting in a short-term tightening effect

More about Pullulan
Disodium phosphate~0.2–0.4%
Formula
Irritation risk
Low

Helps adjust the product pH and stabilize the formulation

More about Disodium phosphate
Potassium phosphate~0.25–0.45%
Formula
Irritation risk
Low

Helps regulate the pH of the formulation

More about Potassium phosphate
Lactococcus ferment lysate~0.2–0.35%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidationAnti-aging

Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin

More about Lactococcus ferment lysate
Cydonia oblonga leaf extract~0.2–0.35%
Formula
Citric acid~0.2–0.35%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Sodium polyacrylate~0.2–0.35%
Formula
Irritation risk
Low
Works for
Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate
Hydrogenated polydecene~0.15–0.3%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin and create a nice product texture

More about Hydrogenated polydecene
Trideceth-6~0.15–0.3%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Trideceth-6
Sodium polyacrylate~0.15–0.3%
Formula
Irritation risk
Low
Works for
Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate
Phenoxyethanol~0.05–0.1%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Benzoic acid~0.01–0.05%
Irritant · medium
Irritation risk
Medium

A preservative

More about Benzoic acid
Dehydroacetic acid~0.01–0.05%
Irritant · medium
Irritation risk
Medium

A preservative

More about Dehydroacetic acid
Dicaprylyl carbonate~0.1–0.15%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps products spread more easily and works as an emollient to soften skin

More about Dicaprylyl carbonate
Polyglyceryl-3 caprate~0.05–0.15%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Polyglyceryl-3 caprate
Ethylene brassylate~0.01–0.05%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Ethylene brassylate
Ingredient list view

Water, Glycerin, Urea, Sodium pca, Trehalose, Polyquaternium-51, Triacetin, Sodium hyaluronate, Isodecyl neopentanoate, Honey, Phospholipids, Sphingolipids, Hyaluronic acid, Glyceryl polyacrylate, Trehalose, Serine, Pentylene glycol, Algin, Caprylyl glycol, Pullulan, Disodium phosphate, Potassium phosphate, Lactococcus ferment lysate, Cydonia oblonga leaf extract, Citric acid, Sodium polyacrylate, Hydrogenated polydecene, Trideceth-6, Sodium polyacrylate, Phenoxyethanol, Benzoic acid, Dehydroacetic acid, Dicaprylyl carbonate, Polyglyceryl-3 caprate, Ethylene brassylate

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ClinidermHydra Defense GelYOUR PRODUCTSkinCeuticalsHydrating B5 Gel - GWPendota spaSensitive H20 GelIndeed LabsIndeed Labs hydraluron moisture jelly
Match—60%60%57%
Price——$107.88$27.41
Shared key ingredients—5 of 115 of 116 of 11
Key difference—Calcium PantothenateBetaineBiosaccharide Gum-1
Irritancy Medium Low Low Low
Drying alcohol————
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