Clinicians Complex Peptide Serum

Clinicians Complex Peptide Serum

Efficacy87/100IrritancyMedium

Works for

Moisturizing
Palmitoyl oligopeptide, Methyl gluceth-20 + 9 more
Works well
What the product description says
“Discover the visible anti-aging benefits of Clinicians Complex Peptide Serum ; a potent formula that contains powerful peptides and natural extracts to defend against aging skin.The water-binding properties of Hyaluronic Acid help to replenish vital moisture, while Red Marine Algae, Aloe Vera and antioxidant Green Tea soothe the complexion while defending against the damage caused by environmental stressors.”
Source: Lookfantastic CA

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: ahnfeltia concinna extract, algae extract.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: algae extract.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl oligopeptide

Palmitoyl oligopeptideHeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~5.3–6.4%
Methyl gluceth-20Key active· HumectantEffect: MediumHelps attract water to the upper layer of the skin and soften it~6.3–7.7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~2.1–2.6%
Ahnfeltia concinna extractKey active· HumectantEffect: HighAn algae extract that helps attract water to the upper layer of the skin. Also used to create a thicker product texture~1.7–2.1%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~1–1.2%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.6–0.9%
Algae extractKey active· Humectant, EmollientEffect: HighPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~0.6–0.85%
Propylene glycol· HumectantEffect: LowHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating~1.5–1.8%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.35%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.55–0.8%
Cucumis sativus fruit extractEffect: Low, below effective doseMight be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effect~0.3–0.6%
Anti-aging
Palmitoyl oligopeptide, Algae extract + 1 more
May help
What the product description says
“Discover the visible anti-aging benefits of Clinicians Complex Peptide Serum ; a potent formula that contains powerful peptides and natural extracts to defend against aging skin.The water-binding properties of Hyaluronic Acid help to replenish vital moisture, while Red Marine Algae, Aloe Vera and antioxidant Green Tea soothe the complexion while defending against the damage caused by environmental stressors.”
Source: Lookfantastic CA

This product contains palmitoyl oligopeptide. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl oligopeptideKey activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~5.3–6.4%
Algae extractEffect: LowPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet~0.6–0.85%
Aloe barbadensis leaf juiceEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.55–0.8%
Anti-oxidation
Side benefit · Camellia oleifera leaf extract, Camellia sinensis extract + 2 more
Works well

This product contains antioxidants (camellia oleifera leaf extract) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - camellia sinensis extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Camellia oleifera leaf extractKey activeEffect: HighA plant extract that can help neutralize free radicals and reduce inflammation, even though it is not usually used in sufficient concentration in cosmetics~0.75–1.1%
Camellia sinensis extractKey activeEffect: MediumTea extract. Might be helpful in neutralizing free radicals in skin~0.65–0.95%
Sambucus nigra flower extractEffect: LowA plant extract that might help neutralize free radicals in skin~0.3–0.55%
Cucumis sativus fruit extractEffect: Low, below effective doseMight be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effect~0.3–0.6%

Can it cause trouble?

Irritancy
2 strong irritants: Arnica montana flower extract, Diazolidinyl urea
Medium risk
We flagged 9 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Propylene glycolHelps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritatingHigh~1.5–1.8%est.
Malva sylvestris extract—High~0.5–0.75%est.
Hedera helix extractA plant extract that has an anti-bacterial effectHigh~0.45–0.65%est.
Sambucus nigra flower extractA plant extract that might help neutralize free radicals in skinHigh~0.3–0.55%est.
Arnica montana flower extractA plant extract that can be irritating. It can have some anti-bacterial properties, but there are no evidence of a beneficial effect for skinHigh~0.25–0.45%est.
Diazolidinyl ureaA preservative. Works by releasing formaldehyde. Can be irritatingHigh~0.15–0.25%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.55–0.8%est.
Cucumis sativus fruit extractMight be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effectMedium~0.3–0.6%est.
Tetrasodium edtaHelps to stabilize the product formulationMedium~0.2–0.4%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Algae extractPlant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet3/5~0.6–0.85%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Methyl gluceth-20~6.3–7.7%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and soften it

More about Methyl gluceth-20
Palmitoyl oligopeptide~5.3–6.4%
Hero · Moisturizing
Irritation risk
Low
Works for
CleansingMoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl oligopeptide
Elaeis guineensis extract~3.2–3.9%
Formula
Tetrapeptide-3~2.4–3%
Formula
Irritation risk
Low
More about Tetrapeptide-3
Glycerin~2.1–2.6%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Ahnfeltia concinna extract~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

An algae extract that helps attract water to the upper layer of the skin. Also used to create a thicker product texture

More about Ahnfeltia concinna extract
Propylene glycol~1.5–1.8%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating

More about Propylene glycol
Hydroxyethylcellulose~1.3–1.6%
Formula
Irritation risk
Low

Used to thicken product formulations and create gel-like textures

More about Hydroxyethylcellulose
Sodium pca~1–1.2%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Camellia oleifera leaf extract~0.75–1.1%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatory

A plant extract that can help neutralize free radicals and reduce inflammation, even though it is not usually used in sufficient concentration in cosmetics

More about Camellia oleifera leaf extract
Camellia sinensis extract~0.65–0.95%
Key active
Irritation risk
Low
Works for
Anti-oxidation

Tea extract. Might be helpful in neutralizing free radicals in skin

More about Camellia sinensis extract
Sodium hyaluronate~0.6–0.9%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Polysorbate 20~0.6–0.9%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Aloe barbadensis leaf juice~0.55–0.8%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-inflammatoryReduces irritationAntibacterialReduces rednessAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Algae extract~0.6–0.85%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-aging

Plant extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but research is not extensive yet

More about Algae extract
Malva sylvestris extract~0.5–0.75%
Irritant · high
Hedera helix extract~0.45–0.65%
Irritant · high
Irritation risk
High
Works for
Antibacterial

A plant extract that has an anti-bacterial effect

More about Hedera helix extract
Cucumis sativus fruit extract~0.3–0.6%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidationMoisturizing

Might be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effect

More about Cucumis sativus fruit extract
Sambucus nigra flower extract~0.3–0.55%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatoryAnti-oxidation

A plant extract that might help neutralize free radicals in skin

More about Sambucus nigra flower extract
Arnica montana flower extract~0.25–0.45%
Irritant · high
Irritation risk
High

A plant extract that can be irritating. It can have some anti-bacterial properties, but there are no evidence of a beneficial effect for skin

More about Arnica montana flower extract
Parietaria officinalis extract~0.25–0.5%
Formula
Tetrasodium edta~0.2–0.4%
Irritant · medium
Irritation risk
Medium

Helps to stabilize the product formulation

More about Tetrasodium edta
Butylene glycol~0.2–0.35%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Carbomer~0.15–0.3%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Diazolidinyl urea~0.15–0.25%
Irritant · high
Irritation risk
High

A preservative. Works by releasing formaldehyde. Can be irritating

More about Diazolidinyl urea
Methylparaben~0.15–0.25%
Formula
Irritation risk
Low

A preservative

More about Methylparaben
Propylparaben~0.1–0.2%
Formula
Irritation risk
Low

A preservative

More about Propylparaben
Ingredient list view

Water, Methyl gluceth-20, Palmitoyl oligopeptide, Elaeis guineensis extract, Tetrapeptide-3, Glycerin, Ahnfeltia concinna extract, Propylene glycol, Hydroxyethylcellulose, Sodium pca, Camellia oleifera leaf extract, Camellia sinensis extract, Sodium hyaluronate, Polysorbate 20, Aloe barbadensis leaf juice, Algae extract, Malva sylvestris extract, Hedera helix extract, Cucumis sativus fruit extract, Sambucus nigra flower extract, Arnica montana flower extract, Parietaria officinalis extract, Tetrasodium edta, Butylene glycol, Carbomer, Diazolidinyl urea, Methylparaben, Propylparaben

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Amazon US1 ouncesPrice as of 11/13 12:36 GMT
$74.09
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Clinicians ComplexPeptide SerumYOUR PRODUCTMakeup Artists' ChoiceTransforming Anti Aging Serum V2The Garden Of WisdomAnti-Aging MultiPeptide SerumBASE SKNCARESuper Youth Serum
Match—57%56%56%
Price$74.09——$60.23−$13.86
Shared key ingredients—4 of 93 of 93 of 9
Key difference—BakuchiolAcetyl Hexapeptide-8Sodium Ascorbyl Phosphate
Irritancy Medium Low Low Low
Drying alcohol————
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Product summary

"Clinicians Complex - Peptide Serum" is effective for: Moisturizing

This product could be helpful for: Anti-inflammatory and Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Peptides (palmitoyl oligopeptide 5.30% - 6.40%). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
  • Humectants (algae extract 0.60% - 0.85%, sodium hyaluronate 0.60% - 0.90%, sodium pca 1.00% - 1.20%, ahnfeltia concinna extract 1.70% - 2.10% and glycerin 2.10% - 2.60%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

Price

The product retails from 69.16$ up to 75.00$ in the United States and for 91.00CA$ in Canada.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 13 studies and safety reviews.

  1. 1
  2. 2
  3. 3
    Propylene Glycolpubmed.ncbi.nlm.nih.gov
  4. 4
  5. 5
  6. 6
Clinicians Complex Peptide Serum
Clinicians ComplexPeptide Serum

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As an Amazon Associate, WIMJ earns from qualifying purchases.