Works for:
based on ingredients and %- Moisturizing
- Anti-aging
Can it cause trouble?
- Irritation risk: high
- Comedogenic risk ingredients: 3
Key actives
Product Summary
Judging from the ingredient list, "Clinicians Complex - Peptide Plus Cream" works well for improving skin hydration This moisturizer uses a good combo of humectants and emollients. These both types of ingredients are essentials for improving the skin hydration and keeping the skin barrier healthy. Glycerin, sodium hyaluronate, sodium pca and butylene glycol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (caprooyl phytosphingosine, ceramide eop, ceramide np, ceramide ns and cholesterol) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- As a plus, this moisturizer also contains ceramides (caprooyl sphingosine 0.20% - 0.40%, caprooyl phytosphingosine 0.25% - 0.50%, ceramide ap 0.25% - 0.45%, ceramide ns 0.30% - 0.55%, ceramide np 0.35% - 0.60%, ceramide eos 0.30% - 0.55% and ceramide eop 0.40% - 0.65%). Ceramides are a type of lipids that our skin produces itself. They are a building block of the skin's barrier. Ceramides used in skincare are synthetic or extracted from plants. They work well for softening the skin surface and "patch holes" in the skin's barrier.
- We like that this moisturizer contains peptides (hexapeptide-3 1.10% - 1.40% and palmitoyl oligopeptide 2.00% - 2.40%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
Irritation risk
This moisturizer contains a bunch of common irritants, including ingredients that do not provide any known benefit for the skin. It might not be the best choice if your skin is sensitive. We assess the overall irritancy of this moisturizer to be high. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails from 57.21$ up to 77.30$ in the United States and for 98.00CA$ in Canada.
For a detailed price comparison: click here.
Works for
Moisturizing
What does the product description say?
Peptide Plus Cream
Source: From product name
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, sodium hyaluronate.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus seed oil, squalane.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: caprooyl phytosphingosine, caprooyl sphingosine, ceramide ap, ceramide eop, ceramide eos, ceramide np, ceramide ns, hexapeptide-3, palmitoyl oligopeptide
A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Naturally present in skin and helps to attract water to its upper layer
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
An emollient that is naturally found in skin
A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
Helps soften upper layer of the skin and can enhance penetration of other ingredients into the upper layer of the skin
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Anti-aging
What does the product description say?
The formula creates a visible lifting effect on the skin, helping to smooth out the appearance of fine lines and wrinkles by up to 45% in just 8 weeks.
Source: Skinstore
This product contains hexapeptide-3, palmitoyl oligopeptide. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Moisturizing | |
| Anti-aging |
Total Promises Fulfilled score: 87/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Clinicians Complex Peptide Plus Cream | Current | $70.00 | |
REVOLUTION SKINCARE Ceramides Moisture Cream | 59% | $9.00 | |
 Peter Thomas Roth Water Drench Hyaluronic Cloud Cream | 58% | $13.20 | |
Paula's choice Clinical Ceramide-Enriched Firming Moisturiser | 58% | $47.60 | |
 L300 INTENSIVE MOISTURE FACE CREAM | 58% | $109.00 | |
 LA CLINICA FOR SKIN & BODY Deep Hydration Moisture Cream | 58% | $66.00 |
Key Actives
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
An emollient that is naturally found in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Naturally present in skin and helps to attract water to its upper layer
Potential irritants
Plant extract. Has some anti-microbial and anti-oxidant properties. Can be irritating
Used as a fragrance. Can be irritating and cause photosensitivity
Oil of a very fragrant pink rose used as fragrance in cosmetics. Extensive research has shown it has mixed benefits. In the pro column, inhaling this flower’s scent seems to have relaxing properties and the plant’s petals contain skin-soothing and antioxidant compounds that can benefit skin. On the flipside, the numerous chemicals that create this rose’s distinctive fragrance pose a risk of causing skin aggravation.
A plant extract that has some anti-oxidant and anti-bacterial properties. Can be irritating
Works as a foaming cleansing agent
Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating
A preservative. Works by releasing formaldehyde. Can be irritating
Helps oil and water mix together. Has some emollient properties
Helps oils and water mix together and works as a cleansing agent
Used to adjust pH of the product and can help improve the product's smell
Can work as an exfoliant but is typically used to adjust the product pH
Comedogenic ingredients
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps oil and water mix together. Has some emollient properties
Works as a foaming cleansing agent
All ingredients
A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps oil and water mix together. Has some emollient properties
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
A component of ceramides. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin
Plant extract. Has some anti-microbial and anti-oxidant properties. Can be irritating
Used as a fragrance. Can be irritating and cause photosensitivity
Oil of a very fragrant pink rose used as fragrance in cosmetics. Extensive research has shown it has mixed benefits. In the pro column, inhaling this flower’s scent seems to have relaxing properties and the plant’s petals contain skin-soothing and antioxidant compounds that can benefit skin. On the flipside, the numerous chemicals that create this rose’s distinctive fragrance pose a risk of causing skin aggravation.
A plant extract that has some anti-oxidant and anti-bacterial properties. Can be irritating
Naturally present in skin and helps to attract water to its upper layer
Helps soften upper layer of the skin and can enhance penetration of other ingredients into the upper layer of the skin
Helps oils and water mix together and works as a cleansing agent
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
Works as a foaming cleansing agent
Used to adjust pH of the product and can help improve the product's smell
Can work as an exfoliant but is typically used to adjust the product pH
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
Helps oil and water mix together and can enhance the penetration of other ingredients into the skin. It can be irritating
A preservative. Works by releasing formaldehyde. Can be irritating
Ingredient list view
Water, Helianthus annuus seed oil, Cetearyl alcohol, Ceteareth-20, Glyceryl stearate, Unknown, Palmitoyl oligopeptide, Elaeis guineensis extract, Tetrapeptide-3, Hexapeptide-3, Squalane, Glycerin, Octyldodecanol, Sodium hyaluronate, Butylene glycol, Behenic acid, Cholesterol, Ceramide eop, Ceramide eos, Ceramide np, Ceramide ns, Ceramide ap, Caprooyl phytosphingosine, Caprooyl sphingosine, Arnica montana extract, Arctium lappa root extract, Citrus limon fruit extract, Rosa damascena extract, Hypericum perforatum flower/leaf extract, Calendula officinalis flower extract, Saponaria officinalis extract, Sodium pca, Cetyl esters, Unknown, Peg-7 glyceryl cocoate, Polysorbate 20, Cetyl alcohol, Sodium laureth sulfate, Triethanolamine, Citric acid, Carbomer, Propylene glycol, Diazolidinyl urea, Methylparaben, Propylparaben
- Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Care
- Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egypt
- Effect of topically applied lipids on surfactant-irritated skin
- Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countries
- Glycerol and the skin: holistic approach to its origin and functions
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Topically Applied Ceramides Interact with the Stratum Corneum Lipid Matrix in Compromised Ex Vivo Skin
- Topical emulsions containing ceramides: Effects on the skin barrier function and anti‐inflammatory properties
- Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
- Safety Assessment of Ceramides as Used in Cosmetics
- Contact dermatitis as an adverse reaction to some topically used European herbal medicinal products – part 1: Achillea millefolium–Curcuma longa
- Safety Assessment of Citrus-Derived Peel Oils as Used in Cosmetics
- Topical application of Calendula officinalis (L.): Formulation and evaluation of hydrophilic cream with antioxidant activity
- The seamy side of natural medicines: contact sensitization to arnica (Arnica montana L.) and marigold (Calendula officinalis L.)
- Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis
- Comparison of skin calming effects of cosmetic products containing 4-t-butylcyclohexanol or acetyl dipeptide-1 cetyl ester on capsaicin-induced facial stinging in volunteers with sensitive skin
- Amended Safety Assessment of Alkyl Esters as Used in Cosmetics
- Surfactants and experimental irritant contact dermatitis
- Propylene Glycol
- Skin-sensitizing and irritant properties of propylene glycol