Biossance

Biossance Squalanne + Growth Factor Firming Moisturizer

Name: Biossance - Squalanne + Growth Factor Firming Moisturizer
Brand: Biossance

Efficacy87/100IrritancyMedium

See all ingredients

Works for

Moisturizing

Hexapeptide-9, Glycerin + 29 more

Works well

What the product description says

“Squalanne + Growth Factor Firming Moisturizer”

Source: Sephora

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, squalane.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: hexapeptide-9

Hexapeptide-9Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.1%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~5–6.2%

Vitis vinifera seed oilKey active· EmollientEffect: HighA great emollient that can also have anti-oxidant properties~4.4–5.4%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~2.7–3.3%

Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~2.1–2.6%

Saccharomyces ferment filtrateKey active· HumectantEffect: HighA product of yeast fermentation. Helps attract water to the upper layer of the skin~1.4–1.8%

UndecaneKey active· EmollientEffect: MediumHelps create a non-greasy finish on the skin~0.9–1.1%

Capryloyl glycerin/sebacic acid copolymerKey activeEffect: MediumHelps soften the upper layer of the skin~0.75–1.15%

Diheptyl succinateKey active· EmollientEffect: MediumHelps to soften the upper layer of the skin and creates a nice product finish on the skin~0.7–1.05%

Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~0.55–0.8%

Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.55–0.85%

Hydrolyzed sodium hyaluronateKey activeEffect: HighAttracts water into the upper layer of the skin~0.5–0.75%

PcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.45–0.65%

ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.45–0.65%

Aspartic acidKey active· HumectantEffect: HighAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.45–0.65%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.4–0.6%

SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.35–0.65%

AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.35–0.65%

GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.35–0.65%

IsoleucineKey activeEffect: HighAn amino acid that can help attract water to the upper layer of the skin and support skin's barrier function~0.25–0.45%

ThreonineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.45%

ProlineKey activeEffect: Medium~0.25–0.5%

Beta-glucanKey activeEffect: HighHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.2–0.35%

CollagenKey activeEffect: MediumCannot penetrate the skin barrier so is not particularly useful in skincare products~0.2–0.35%

HistidineKey active· HumectantEffect: High~0.15–0.25%

GlucoseKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function~0.1–0.2%

Nicotiana benthamiana hexapeptide-40 sh-polypeptide-76Key activeEffect: HighA fusion peptide that combines peptides produced by human and plant cells. It might have anti-aging effect in skin and can help the skin moisturization~0.05–0.1%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~1.3–1.6%

AlginEffect: LowUsed to thicken product formulation. Can help attract water to the upper layer of the skin~0.45–0.65%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.65–0.95%

Anti-aging

Aspartic acid, Serine + 5 more

May help

What the product description says

“Visibly firms skin with biomimetic growth factor, a plant-based peptide that improves the look of laxity, fine lines, and bounce.”

Source: Sephora

This product contains aspartic acid, hexapeptide-9, serine, threonine. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Aspartic acidKey activeEffect: MediumAn amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles~0.45–0.65%

SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.35–0.65%

ThreonineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.45%

Hexapeptide-9Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.05–0.1%

Beta-glucanEffect: LowHelps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles~0.2–0.35%

Nicotiana benthamiana hexapeptide-40 sh-polypeptide-76Effect: LowA fusion peptide that combines peptides produced by human and plant cells. It might have anti-aging effect in skin and can help the skin moisturization~0.05–0.1%

Can it cause trouble?

Irritancy

8 flagged ingredients

Medium risk

We flagged 8 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Vitis vinifera seed oilA great emollient that can also have anti-oxidant propertiesMedium~4.4–5.4%est.

UndecaneHelps create a non-greasy finish on the skinMedium~0.9–1.1%est.

TridecaneHelps create a dry, non-greasy finish of the skinMedium~0.6–0.9%est.

EthylhexylglycerinA preservativeMedium~0.6–0.9%est.

Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~0.55–0.8%est.

Potassium sorbateA preservativeMedium~0.3–0.6%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.

1,2-hexanediolA preservativeMedium~0.25–0.4%est.

Comedogenic

2 ingredients rated 2 or more on the 0–5 pore-clogging scale

2 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

AlginUsed to thicken product formulation. Can help attract water to the upper layer of the skin3/5~0.45–0.65%est.

Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~2.1–2.6%est.

Alternatives

Cheaper, or higher on efficacy

NEOGEN X SUR.MEDIC Probiotics Youth Repair Cream

CheaperHigher efficacy · 100/10060% match

$26.20

Filorga Protection Treatments Universal Cream

Higher efficacy · 100/10059% match

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~5–6.2%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Vitis vinifera seed oil~4.4–5.4%

Key activeIrritant · medium

Irritation risk: Medium

Works for

MoisturizingAnti-oxidation

A great emollient that can also have anti-oxidant properties

More about Vitis vinifera seed oil

Propanediol~3.2–4%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Squalane~2.7–3.3%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Cetearyl alcohol~2.1–2.6%

Key activeComedogenic 2/5

Irritation risk: Low
Comedogenicity: 2/5

Works for

CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol

Sodium polyacrylate~1.8–2.2%

Formula

Irritation risk: Low

Works for

Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate

Saccharomyces ferment filtrate~1.4–1.8%

Key active

Irritation risk: Low

Works for

Moisturizing

A product of yeast fermentation. Helps attract water to the upper layer of the skin

More about Saccharomyces ferment filtrate

Butylene glycol~1.3–1.6%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Phenoxyethanol~0.5–1%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Undecane~0.9–1.1%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps create a non-greasy finish on the skin

More about Undecane

Capryloyl glycerin/sebacic acid copolymer~0.75–1.15%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin

More about Capryloyl glycerin/sebacic acid copolymer

Diheptyl succinate~0.7–1.05%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to soften the upper layer of the skin and creates a nice product finish on the skin

More about Diheptyl succinate

Tridecane~0.6–0.9%

Irritant · medium

Irritation risk: Medium

Helps create a dry, non-greasy finish of the skin

More about Tridecane

Tocopherol~0.65–0.95%

Formula

Irritation risk: Low

Works for

Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Ethylhexylglycerin~0.6–0.9%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Sodium pca~0.55–0.85%

Key active

Irritation risk: Low

Works for

Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca

Sodium lactate~0.55–0.8%

Key activeIrritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate

Hydrolyzed sodium hyaluronate~0.5–0.75%

Key active

Irritation risk: Low

Works for

Moisturizing

Attracts water into the upper layer of the skin

More about Hydrolyzed sodium hyaluronate

Sodium gluconate~0.45–0.7%

Formula

Irritation risk: Low

Helps stabilize product formulations

More about Sodium gluconate

Arginine~0.45–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine

Aspartic acid~0.45–0.65%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles

More about Aspartic acid

Pca~0.45–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Pca

Sodium benzoate~0.25–0.5%

Formula

Irritation risk: Low

A preservative

More about Sodium benzoate

Potassium sorbate~0.3–0.6%

Irritant · medium

Irritation risk: Medium

A preservative

More about Potassium sorbate

Algin~0.45–0.65%

Comedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

Moisturizing

Used to thicken product formulation. Can help attract water to the upper layer of the skin

More about Algin

Glycine~0.35–0.65%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Alanine~0.35–0.65%

Key active

Irritation risk: Low

Works for

MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine

Serine~0.35–0.65%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine

Sodium hyaluronate~0.4–0.6%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Valine~0.3–0.6%

Formula

Irritation risk: Low

More about Valine

Isoleucine~0.25–0.45%

Key active

Irritation risk: Low

Works for

Moisturizing

An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function

More about Isoleucine

Proline~0.25–0.5%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Proline

Pseudostellaria heterophylla extract

Not recognized

Threonine~0.25–0.45%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Threonine

Caprylyl glycol~0.25–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

1,2-hexanediol~0.25–0.4%

Irritant · medium

Irritation risk: Medium

A preservative

More about 1,2-hexanediol

Beta-glucan~0.2–0.35%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-inflammatoryReduces irritationAnti-agingAnti-blemishAnti-oxidation

Helps attract water to the upper layer of the skin, calm down inflammation and irritation, restore the barrier function and support wound healing. It can be helpful in reducing fine lines and wrinkles

More about Beta-glucan

Calcium citrate~0.2–0.35%

Formula

Irritation risk: Low

Helps stabilize the product formulation

More about Calcium citrate

Collagen~0.2–0.35%

Key active

Irritation risk: Low

Works for

Moisturizing

Cannot penetrate the skin barrier so is not particularly useful in skincare products

More about Collagen

Mannose~0.15–0.3%

Formula

Irritation risk: Low

More about Mannose

Histidine~0.15–0.25%

Key active

Irritation risk: Low

Works for

Moisturizing

More about Histidine

Phenylalanine~0.15–0.25%

Formula

Irritation risk: Low

More about Phenylalanine

Sodium hydroxide~0.1–0.25%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Glucose~0.1–0.2%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin. Could be helpful in restoring the skin barrier function

More about Glucose

Hexapeptide-9~0.05–0.1%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Hexapeptide-9

Nicotiana benthamiana hexapeptide-40 sh-polypeptide-76~0.05–0.1%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

A fusion peptide that combines peptides produced by human and plant cells. It might have anti-aging effect in skin and can help the skin moisturization

More about Nicotiana benthamiana hexapeptide-40 sh-polypeptide-76

Ingredient list view

Water, Glycerin, Vitis vinifera seed oil, Propanediol, Squalane, Cetearyl alcohol, Sodium polyacrylate, Saccharomyces ferment filtrate, Butylene glycol, Phenoxyethanol, Undecane, Capryloyl glycerin/sebacic acid copolymer, Diheptyl succinate, Tridecane, Tocopherol, Ethylhexylglycerin, Sodium pca, Sodium lactate, Hydrolyzed sodium hyaluronate, Sodium gluconate, Arginine, Aspartic acid, Pca, Sodium benzoate, Potassium sorbate, Algin, Glycine, Alanine, Serine, Sodium hyaluronate, Valine, Isoleucine, Proline, Unknown, Threonine, Caprylyl glycol, 1,2-hexanediol, Beta-glucan, Calcium citrate, Collagen, Mannose, Histidine, Phenylalanine, Sodium hydroxide, Glucose, Hexapeptide-9, Nicotiana benthamiana hexapeptide-40 sh-polypeptide-76

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	BiossanceSqualanne + Growth Factor Firming MoisturizerYOUR PRODUCT	NEOGEN X SUR.MEDICProbiotics Youth Repair Cream	FilorgaProtection Treatments Universal Cream	FaceGymSupreme Restructure Firming EGF Collagen Boosting Cream
Match	—	60%	59%	58%
Price	$64.00	$26.20−$37.80	—	$120.00+$56.00
Shared key ingredients	—	16 of 22	12 of 22	12 of 22
Key difference	—	Hexapeptide-11	Niacinamide	Niacinamide
Irritancy	Medium	Medium	Medium	Medium
Drying alcohol	—	—	—	—
	View product	Shop	Shop	Shop

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Product summary

"Biossance - Squalanne + Growth Factor Firming Moisturizer" is effective for: Moisturizing

This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

Peptides (hexapeptide-9 0.05% - 0.10%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Humectants (hexapeptide-9 0.05% - 0.10%, histidine 0.15% - 0.25%, sodium hyaluronate 0.40% - 0.60%, alanine 0.35% - 0.65%, glycine 0.35% - 0.65%, pca 0.45% - 0.65%, aspartic acid 0.45% - 0.65%, arginine 0.45% - 0.65%, sodium lactate 0.55% - 0.80%, sodium pca 0.55% - 0.85%, saccharomyces ferment filtrate 1.40% - 1.80% and glycerin 5.00% - 6.20%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

About the brand

According to Cruelty-Free Kitty "Biossance" is cruelty free and so is its parent company.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 24 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Vitamin E in dermatologyncbi.nlm.nih.gov
3
Vitamin E and Skin Healthlpi.oregonstate.edu
4
Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proofncbi.nlm.nih.gov
5
In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmnessncbi.nlm.nih.gov
6
Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiencyjamanetwork.com
7
Functional glycine receptor in cultured human keratinocytesonlinelibrary.wiley.com
8
Combination of amino acids reduces pigmentation in B16F0 melanoma cellsncbi.nlm.nih.gov
9
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skinonlinelibrary.wiley.com
10
Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
11
Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
12
Local rhamnosoft, ceramides and L‐isoleucine in atopic eczema: a randomized, placebo controlled trialonlinelibrary.wiley.com
13
The influence of alkane chain length on the skin irritation potential of 1,2-alkanediolsncbi.nlm.nih.gov
14
β-Glucans: Multi-Functional Modulator of Wound Healingncbi.nlm.nih.gov
15
Anti-Wrinkle Therapy: Significant New Findings in the Non-Invasive Cosmetic Treatment of Skin Wrinkles with Beta-Glucanonlinelibrary.wiley.com
16
Skin Health Promotion Effects of Natural Beta-Glucan Derived from Cereals and Microorganisms: A Reviewonlinelibrary.wiley.com
17
Anticancer properties of low molecular weight oat beta-glucan – An in vitro studysciencedirect.com
18
A critical review on production and industrial applications 2 of beta-glucanssciencedirect.com
19
Improving skin function with CM-glucan, a biological response modifier from yeastonlinelibrary.wiley.com
20
Preparation, characterization, and biological properties of β-glucansncbi.nlm.nih.gov
21
Characterization of a new beta(1-3)-glucan branching activity of Aspergillus fumigatusncbi.nlm.nih.gov
22
Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseasespatents.google.com
23
Safety Assessment of α-Amino Acids as Used in Cosmeticsciteseerx.ist.psu.edu
24
Topical Glucose Induces Claudin-1 and Filaggrin Expression in a Mouse Model of Atopic Dermatitis and in Keratinocyte Culture, Exerting Anti-inflammatory Effects by Repairing Skin Barrier Functionncbi.nlm.nih.gov

BiossanceSqualanne + Growth Factor Firming Moisturizer

Buy at Sephora$64.00 Amazon

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Sephora$64.00 Amazon

As an Amazon Associate, WIMJ earns from qualifying purchases.