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Biophile Root Bionic Refining Essence
Biophile

Biophile Root Bionic Refining Essence

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Evens skin tone
Gluconolactone, Lactobionic acid
Works well
What the product description says
“Improves skin texture and tone.”
Source: Bluemercury

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: gluconolactone, lactobionic acid

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~3.9–5.9%
Lactobionic acidKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity~2.1–3.1%
Moisturizing
Lactobionic acid, Gluconolactone + 8 more
Works well
What the product description says
“This concentrated refining essence instantly smoothes, hydrates and tones skin for a fresh, dewy glow.”
Source: Bluemercury

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: arginine, betaine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: lactobionic acid

Lactobionic acidHeroEffect: HighA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity~2.1–3.1%
GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~3.9–5.9%
BetaineKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin and improves the product texture~1.6–2.4%
Sodium lactateKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product~1.2–1.9%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~1–1.5%
InulinKey activeEffect: HighHelps attract water to the upper layer of the skin. Is claimed to support the growth of "good" bacteria in skin (as a "prebiotic"), but the research is lacking~0.4–1%
Alpha-glucan oligosaccharideKey activeEffect: HighHelps attract water to the upper layer of the skin~0.35–0.8%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.15–0.5%
ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.05–0.15%
Aloe barbadensis leaf juice· HumectantEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~6.7–10%
Exfoliation
Gluconolactone, Lactobionic acid + 1 more
Works well
What the product description says
“Lactobionic Acid, a unique polyhydroxy acid (PHA) with antioxidant and prebiotic activity, is combined with Willowbark Extract, Hyaluronic Acid and Biophile's nutrient-rich Roots Biotic Broth™ for a next-generation treatment that resurfaces and regenerates skin while supporting overall microbiome health.”
Source: Bluemercury

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: gluconolactone, lactobionic acid.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~3.9–5.9%
Lactobionic acidKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity~2.1–3.1%
Salix alba bark extractEffect: LowA plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect~0.45–1.05%
Anti-aging
Side benefit · Gluconolactone, Lactobionic acid + 1 more
Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains gluconolactone, lactobionic acid.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

GluconolactoneKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~3.9–5.9%
Lactobionic acidKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity~2.1–3.1%
Aloe barbadensis leaf juiceEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~6.7–10%
Anti-oxidation
Side benefit · Gluconolactone, Lactobionic acid + 1 more
Works well

This product contains antioxidants (lactobionic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - gluconolactone also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

GluconolactoneKey activeEffect: MediumA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals~3.9–5.9%
Lactobionic acidKey activeEffect: HighA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity~2.1–3.1%
Salix alba bark extractEffect: LowA plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect~0.45–1.05%

Can it cause trouble?

Irritancy
1 strong irritant: Citrus aurantium amara flower extract
Medium risk
We flagged 6 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Salix alba bark extractA plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effectHigh~0.45–1.05%est.
Citrus aurantium amara flower extractUsed as a fragrance for its citrus smell. Can be irritatingHigh~0.05–0.25%est.
Aloe barbadensis leaf juiceTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~6.7–10%est.
GluconolactoneA polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicalsMedium~3.9–5.9%est.
Lactobionic acidA polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticityMedium~2.1–3.1%est.
Sodium lactateHelps attract water to the upper layer of the skin. Is often used to adjust the pH level of the productMedium~1.2–1.9%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged
Alternatives
The closest match we found
PHA Topical Acid 12%
Naturium PHA Topical Acid 12%
Closest match62% match
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Bifida/lactobacillus/(arctium lappa/ginger/licorice) root extract/yeast extract ferment lysate filtrate~39–58%
Formula
Irritation risk
Low
More about Bifida/lactobacillus/(arctium lappa/ginger/licorice) root extract/yeast extract ferment lysate filtrate
Aloe barbadensis leaf juice~6.7–10%
Irritant · medium
Irritation risk
Medium
Works for
MoisturizingAntibacterialAnti-inflammatoryReduces irritationReduces rednessAnti-blemishAnti-aging

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice
Gluconolactone~3.9–5.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-agingMoisturizingExfoliationEvens skin toneAnti-oxidationAnti-blemish

A polyhydroxy acid (PHA) that helps shed the dead cells from the skin surface revealing smoother skin. Is believed to be genter than AHAs. It helps attract water to the upper layer of the skin and can stimulate production of skin's own hyaluronic acid resulting in improved hydration levels. It has been shown to be helpful against acne and clogged pores if used consistently (e.g over a period of 12 weeks) in high enough concentration. It can help reduce fine lines and wrinkles and improve skin tone with long-term application. Can help neutralize free radicals

More about Gluconolactone
Propanediol~2.8–4.2%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Lactobionic acid~2.1–3.1%
Hero · MoisturizingIrritant · medium
Irritation risk
Medium
Works for
ExfoliationEvens skin toneAnti-agingAnti-oxidationMoisturizingAnti-blemishAnti-inflammatory

A polyhydroxy acid (PHA) that helps shed dead cells from the surface of the skin revealing a smoother, more even skin. PHAs tend to be gentler on the skin compared to AHAs (for example, glycolic acid). It also has hydrating properties and helps attract water to the upper layer of the skin. It can help calm down inflammation in skin and support restoration of the barrier function. It has an anti-oxidant effect as well. It can help reduce fine line, wrinkles and improve skin elasticity

More about Lactobionic acid
Betaine~1.6–2.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Betaine
Sodium lactate~1.2–1.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product

More about Sodium lactate
Glycerin~1–1.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Salix alba bark extract~0.45–1.05%
Irritant · high
Irritation risk
High
Works for
Anti-oxidationAnti-inflammatoryAnti-blemishExfoliation

A plant extract that can help neutralize free radicals in skin. It contains a compound salicin that can theoretically be converted into salicylic acid that, in turn, helps reduce inflammation in skin, but the evidence of effectiveness in skin is lacking and the extract is usually not used in a concentration that would enable an exfoliating effect

More about Salix alba bark extract
Inulin~0.4–1%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-blemish

Helps attract water to the upper layer of the skin. Is claimed to support the growth of "good" bacteria in skin (as a "prebiotic"), but the research is lacking

More about Inulin
Alpha-glucan oligosaccharide~0.35–0.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Alpha-glucan oligosaccharide
Sodium hyaluronate~0.15–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Water~0.1–0.35%
Formula
Irritation risk
Low

Plain old water

More about Water
Citrus aurantium amara flower extract~0.05–0.25%
Irritant · high
Irritation risk
High

Used as a fragrance for its citrus smell. Can be irritating

More about Citrus aurantium amara flower extract
Arginine~0.05–0.15%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Ingredient list view

Bifida/lactobacillus/(arctium lappa/ginger/licorice) root extract/yeast extract ferment lysate filtrate, Aloe barbadensis leaf juice, Gluconolactone, Propanediol, Lactobionic acid, Betaine, Sodium lactate, Glycerin, Salix alba bark extract, Inulin, Alpha-glucan oligosaccharide, Sodium hyaluronate, Water, Citrus aurantium amara flower extract, Arginine

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
BiophileRoot Bionic Refining EssenceYOUR PRODUCTNaturiumPHA Topical Acid 12%Geek GorgeousCalm Down LiquidBeautyAct5% AHA + 5% PHA Glow Toner
Match—62%59%57%
Price——$13.02—
Shared key ingredients—4 of 93 of 93 of 9
Key difference—Mandelic AcidSalicylic AcidGlycolic Acid
Irritancy Medium Low Low Low
Drying alcohol——— Contains drying alcohol
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 20 studies and safety reviews.

  1. 1
    A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acnencbi.nlm.nih.gov
  2. 2
    The Polyhydroxy Acid Gluconolactone Protects Against Ultraviolet Radiation in an In Vitro Model of Cutaneous Photoagingonlinelibrary.wiley.com
  3. 3
    Applications of hydroxy acids: classification, mechanisms, and photoactivityncbi.nlm.nih.gov
  4. 4
    The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative studydovepress.com
  5. 5
    A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimenncbi.nlm.nih.gov
  6. 6
    The use of polyhydroxy acids (PHAs) in photoaged skin
Biophile Root Bionic Refining Essence
BiophileRoot Bionic Refining Essence
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