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ADVANCED CLINICALS Retinol Serum
ADVANCED CLINICALS

ADVANCED CLINICALS Retinol Serum

Efficacy91/100IrritancyHigh·100% recommend (1 review)
See all ingredients

Works for

Evens skin tone
Retinol, Camellia sinensis leaf extract
Works well
What the product description says
“Improves the look of uneven tone and texture.”
Source: Advanced Clinicals

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: retinol.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.65–1%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.5–0.75%
Anti-aging
Retinol, Camellia sinensis leaf extract + 1 more
Works well
What the product description says
“This Retinol Face Serum, infused with Squalane, Green Tea, and Vitamin E, helps hydrate and visibly reduce the look of fine lines and wrinkles.”
Source: Advanced Clinicals

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains retinol.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.65–1%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.5–0.75%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.55–0.85%
Moisturizing
Isopropyl myristate, Glycerin + 11 more
Works
What the product description says
“This Retinol Face Serum, infused with Squalane, Green Tea, and Vitamin E, helps hydrate and visibly reduce the look of fine lines and wrinkles.”
Source: Advanced Clinicals

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, caprylyl glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: copernicia cerifera wax, helianthus annuus seed oil.

Isopropyl myristateKey active· EmollientEffect: HighAn emollient that helps soften the skin. Could be comedogenic~5.5–6.7%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4–4.8%
Ethylhexyl olivateKey activeEffect: HighHelps soften the upper layer of the skin~3.1–3.8%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~2.3–2.9%
Pyrus malus fruit extractKey activeEffect: MediumCan have some moisturizing properties due to its sugar content~1.9–2.3%
SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~1.7–2.1%
Helianthus annuus extractKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.45–0.65%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.6%
Copernicia cerifera waxKey active· Emollient, OcclusiveEffect: HighHelps to soften the upper layer of the skin and create a nice product consistency~0.3–0.55%
Aloe barbadensis leaf juice powderEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~1.4–1.7%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.5–0.75%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.55–0.85%
Exfoliation
Side benefit · Retinol
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: retinol.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.65–1%
Anti-blemish
Side benefit · Retinol, Camellia sinensis leaf extract + 1 more
Works well

This product can help reduce breakouts and clogged pores because it contains the following ingredient: retinol. This ingredient is used for treating acne and can have a noticeable effect.

RetinolHeroEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.65–1%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.5–0.75%
Rosmarinus officinalis leaf extractUnder-dosedCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.3–0.55%
Anti-oxidation
Side benefit · Retinol, Camellia sinensis leaf extract + 3 more
Works well

This product contains antioxidants (retinol) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - camellia sinensis leaf extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

RetinolKey activeEffect: HighTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating~0.65–1%
Camellia sinensis leaf extractKey activeEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.5–0.75%
Pyrus malus fruit extractEffect: LowCan have some moisturizing properties due to its sugar content~1.9–2.3%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.3–0.55%
TocopherolUnder-dosedPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.55–0.85%

Can it cause trouble?

Irritancy
6 strong irritants: Retinol, Citrus aurantium dulcis peel extract + 4 more — patch-test recommended
High risk
We flagged 14 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
RetinolTwo steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritatingHigh~0.65–1%est.
Citrus aurantium dulcis peel extractUsed as a fragranceHigh~0.35–0.6%est.
Humulus lupulus extractHops extract. Can contain common irritants and allergens geraniol, limonene, linaloolHigh~0.35–0.65%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.3–0.55%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05–0.15%est.
LimoneneA common frangrance that can easily irritate skin, especially if exposed to air, light or heatHigh~0.05–0.1%est.
Pyrus malus fruit extractCan have some moisturizing properties due to its sugar contentMedium~1.9–2.3%est.
Aloe barbadensis leaf juice powderTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~1.4–1.7%est.
Avena sativa bran extract—Medium~1.1–1.4%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
EthylhexylglycerinA preservativeMedium~0.25–0.4%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.2–0.4%est.
1,2-hexanediolA preservativeMedium~0.15–0.25%est.
Disodium cocoamphodipropionateHelps oil and water mix togetherMedium~0.25–0.45%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Isopropyl myristateAn emollient that helps soften the skin. Could be comedogenic3/5~5.5–6.7%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~2.3–2.9%est.
Alternatives
Cheaper, or higher on efficacy
Empower Anti-Wrinkle Treatment
Dermelect Empower Anti-Wrinkle Treatment
Higher efficacy · 100/10086% match
$75.00
Retinol Complex 1.0
SkinMedica Retinol Complex 1.0
Higher efficacy · 100/10085% match
$76.80
View all alternatives

User reviews

Would you recommend?
100%·yes

1 of 1 community members would buy it again.

100% would0% wouldn't
  • Nany· May 2025Recommends

    The Advanced Clinicals Retinol Serum is absolutely amazing. I usually see results within just a few days — and honestly, I often notice a slight improvement after the very first night. (Just remember: retinol should only be used at night, since light breaks down the molecule and reduces its effectiveness!)

    I personally use it along with the glycolic acid from the same brand (Advanced Clinicals), and the combination makes my skin look incredible. I apply glycolic acid first, then the retinol — always at night, preferably right before bed, so it doesn’t lose its effectiveness due to light exposure. However, it’s important to test your skin’s sensitivity first, especially when combining actives. Not everyone tolerates this combo well at first. And of course, even though you’re applying it at night, it’s highly recommended to use sunscreen daily, since your skin will be more sensitive during the day.

    What I’ve noticed from using this serum is that it helps with skin recovery, evens out my complexion, and improves overall texture and glow. With consistent use, the results become even more noticeable. It also helps to reduce acne, shrink the appearance of pores, and fade dark spots and hyperpigmentation over time. It boosts cell turnover, which is key for smoother, clearer, and healthier-looking skin.

    As for the anti-aging benefits: yes, it helps maintain youthful skin and prevent premature aging. But let’s be honest — NO cream or serum will reverse aging, and that’s true for ANY brand. Rejuvenation requires professional treatments. Skincare products help maintain results, not perform miracles.

    That said, I absolutely recommend this serum. Every product I’ve tried from Advanced Clinicals has been excellent — and this one is definitely a favorite!

What reviewers noticed
Marker shows the average response

Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Isopropyl myristate~5.5–6.7%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin. Could be comedogenic

More about Isopropyl myristate
Glycerin~4–4.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Ethylhexyl olivate~3.1–3.8%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Ethylhexyl olivate
Cetearyl alcohol~2.3–2.9%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Pyrus malus fruit extract~1.9–2.3%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

Can have some moisturizing properties due to its sugar content

More about Pyrus malus fruit extract
Squalane~1.7–2.1%
Key active
Irritation risk
Low
Works for
Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane
Aloe barbadensis leaf juice powder~1.4–1.7%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice powder
Propanediol~1.2–1.5%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Avena sativa bran extract~1.1–1.4%
Irritant · medium
Irritation risk
Medium
More about Avena sativa bran extract
Retinol~0.65–1%
Hero · Anti-aging, Evens skin tone, Anti-blemishIrritant · high
Irritation risk
High
Works for
Anti-oxidationEvens skin toneAnti-blemishMattifyingExfoliationAnti-aging

Two steps removed from the active form of vitamin A - retinoic acid. Once converted to the retinoic acid in the skin, retinol is proven to be effective against all signs of aging. It improves skin cell turnover, helps fight blemishes and clogged pores, can regulate excess oil production and even skin tone. It can, however, be quite irritating

More about Retinol
Tocopherol~0.55–0.85%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Camellia sinensis leaf extract~0.5–0.75%
Key active
Irritation risk
Low
Works for
Anti-oxidationAntibacterialAnti-agingMoisturizingEvens skin toneAnti-blemish

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Oryza sativa bran extract~0.45–0.65%
Formula
Irritation risk
Low

Used to thicken the product consistency

More about Oryza sativa bran extract
Citrus aurantium dulcis peel extract~0.35–0.6%
Irritant · high
Irritation risk
High

Used as a fragrance

More about Citrus aurantium dulcis peel extract
Helianthus annuus extract~0.45–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Helianthus annuus extract
Humulus lupulus extract~0.35–0.65%
Irritant · high
Irritation risk
High

Hops extract. Can contain common irritants and allergens geraniol, limonene, linalool

More about Humulus lupulus extract
Rosmarinus officinalis leaf extract~0.3–0.55%
Under-dosedIrritant · high
Irritation risk
High
Works for
Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Helianthus annuus seed oil~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Ammonium acryloyldimethyltaurate/vp copolymer~0.3–0.55%
Formula
Irritation risk
Low

Increases thickness of a product. Texture enhancer for oil-in-water emulsions

More about Ammonium acryloyldimethyltaurate/vp copolymer
Phenoxyethanol~0.3–0.5%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Ethylhexylglycerin~0.25–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Hexylene glycol~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Cyamopsis tetragonoloba gum~0.2–0.4%
Formula
Irritation risk
Low
More about Cyamopsis tetragonoloba gum
Copernicia cerifera wax~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to soften the upper layer of the skin and create a nice product consistency

More about Copernicia cerifera wax
Polysorbate 20~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Tetrasodium glutamate diacetate~0.2–0.35%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
1,2-hexanediol~0.15–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Disodium cocoamphodipropionate~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Disodium cocoamphodipropionate
Xanthan gum~0.15–0.25%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Ethyl ferulate~0.1–0.2%
Formula
Irritation risk
Low
More about Ethyl ferulate
Parfum~0.05–0.15%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Limonene~0.05–0.1%
Irritant · high
Irritation risk
High

A common frangrance that can easily irritate skin, especially if exposed to air, light or heat

More about Limonene
Ingredient list view

Water, Isopropyl myristate, Glycerin, Ethylhexyl olivate, Cetearyl alcohol, Pyrus malus fruit extract, Squalane, Aloe barbadensis leaf juice powder, Propanediol, Avena sativa bran extract, Retinol, Tocopherol, Camellia sinensis leaf extract, Oryza sativa bran extract, Citrus aurantium dulcis peel extract, Helianthus annuus extract, Humulus lupulus extract, Rosmarinus officinalis leaf extract, Helianthus annuus seed oil, Ammonium acryloyldimethyltaurate/vp copolymer, Phenoxyethanol, Caprylyl glycol, Ethylhexylglycerin, Hexylene glycol, Cyamopsis tetragonoloba gum, Copernicia cerifera wax, Polysorbate 20, Tetrasodium glutamate diacetate, 1,2-hexanediol, Disodium cocoamphodipropionate, Xanthan gum, Ethyl ferulate, Parfum, Limonene

Compare prices

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Advanced Clinicals
$12.99
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Amazon USPrice as of 11/9 03:40 GMT
$29.99
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ADVANCED CLINICALSRetinol SerumYOUR PRODUCTDermelectEmpower Anti-Wrinkle TreatmentSaint Jane BeautySacred Sleep Retinol RepairSkinMedicaRetinol Complex 1.0
Match—86%85%85%
Price$12.99$75.00+$62.01$70.00+$57.01$76.80+$63.81
Shared key ingredients—4 of 114 of 114 of 11
Key difference—Lactic AcidCannabis Sativa Seed OilNiacinamide
Irritancy High Medium Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 15 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Retinoids in the treatment of skin aging: an overview of clinical efficacy and safetyncbi.nlm.nih.gov
  3. 3
    Improvement of naturally aged skin with vitamin A (retinol)ncbi.nlm.nih.gov
  4. 4
    A comparative study of the effects of retinol and retinoic acid on histological, molecular, and clinical properties of human skinonlinelibrary.wiley.com
  5. 5
    Vitamin E in dermatologyncbi.nlm.nih.gov
  6. 6
    Vitamin E and Skin Healthlpi.oregonstate.edu
ADVANCED CLINICALS Retinol Serum
ADVANCED CLINICALSRetinol Serum
Buy at Advanced Clinicals$12.99$29.99as of 11/9 03:40 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Advanced Clinicals$12.99$29.99as of 11/9 03:40 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.