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ADVANCED CLINICALS Collagen + Peptide Body Cream
ADVANCED CLINICALS

ADVANCED CLINICALS Collagen + Peptide Body Cream

Efficacy87/100IrritancyHigh
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Works for

2 of 2 advertised claims delivered

Moisturizing
20 ingredients credited for this claim
Strong evidence
What the product description says
“This Collagen + Peptides Body Cream, infused with Shea Butter, Green Tea Extract, and Vitamin E, delivers hydration to visibly plump and smooth the appearance of crepey, aging skin while improving elasticity and texture.”
Source: Advanced Clinicals

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, soluble collagen.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: butyrospermum parkii butter, dimethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8

Acetyl hexapeptide-8Hero· HumectantEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.8–1.2%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.9–4.8%
Butyrospermum parkii butterKey active· Emollient, OcclusiveEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~2.4–2.9%
Isopropyl myristateKey active· EmollientEffect: HighAn emollient that helps soften the skin. Could be comedogenic~1.6–2%
Helianthus annuus extractKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.2–0.4%
DimethiconeKey active· Emollient, OcclusiveEffect: HighA silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish~3.2–3.9%
Soluble collagenKey active· HumectantEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~1.4–1.7%
Synthetic beeswaxKey activeEffect: HighHelps soften the upper layer of the skin~0.2–0.4%
Chenopodium quinoa seed extractKey activeEffect: HighHelps soften the upper layer of the skin~0.35–0.65%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~4.8–5.9%
Aloe barbadensis leaf juice powderEffect: LowTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.5–0.8%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.25–0.45%
Glyceryl stearate· EmollientEffect: LowAn emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together~0.25–0.45%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.2–0.35%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.4%
Cetearyl ethylhexanoate· EmollientEffect: LowAn emollient that helps soften the skin~0.25–0.45%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.3–0.55%
Pyrus malus fruit extractUnder-dosedEffect: MediumCan have some moisturizing properties due to its sugar content~0.2–0.4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.65%
Oryza sativa extractEffect: Low, below effective doseA grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin~0.3–0.5%
Anti-aging
4 ingredients credited for this claim
Moderate evidence
What the product description says
“This Collagen + Peptides Body Cream, infused with Shea Butter, Green Tea Extract, and Vitamin E, delivers hydration to visibly plump and smooth the appearance of crepey, aging skin while improving elasticity and texture.”
Source: Advanced Clinicals

This product contains acetyl hexapeptide-8. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Acetyl hexapeptide-8Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.8–1.2%
Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.3–0.55%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~2.4–2.9%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.65%
Anti-oxidation
Not advertised by the brand · 8 ingredients credited for this claim
Moderate evidence

This product contains antioxidants (camellia sinensis leaf extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Camellia sinensis leaf extractKey activeEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.3–0.55%
Butyrospermum parkii butterEffect: LowA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~2.4–2.9%
Daucus carota sativa root extractEffect: LowCarrot extract. Might have anti-oxidant properties and be used to add orange color~0.35–0.65%
TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.35–0.65%
Pyrus malus fruit extractEffect: Low, below effective doseCan have some moisturizing properties due to its sugar content~0.2–0.4%
Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.2–0.4%
Oryza sativa extractEffect: Low, below effective doseA grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin~0.3–0.5%
Panax ginseng root extractEffect: Low, below effective doseA plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating~0.35–0.6%

Can it cause trouble?

Irritancy
4 strong irritants: Rosmarinus officinalis leaf extract, Parfum + 2 more — patch-test recommended
High risk
We flagged 15 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Panax ginseng root extractA plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritatingHigh~0.35–0.6%est.
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.2–0.4%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.15–0.3%est.
LinaloolA fragrance. Can be irritatingHigh~0.1–0.15%est.
Hexyl cinnamalA fragrance with jasmine smell. A likely irritantHigh~0.1–0.15%est.
Ceteareth-20Helps oil and water mix together. Has some emollient propertiesMedium~2–2.4%est.
Aloe barbadensis leaf juice powderTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.5–0.8%est.
Pyrus malus fruit extractCan have some moisturizing properties due to its sugar contentMedium~0.2–0.4%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.4%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.2–0.4%est.
EthylhexylglycerinA preservativeMedium~0.2–0.4%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.25–0.45%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.15–0.3%est.
Sodium citrateHelps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve productsMedium~0.15–0.3%est.
Potassium sorbateA preservativeMedium~0.15–0.3%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~2.4–2.9%est.
Isopropyl myristateAn emollient that helps soften the skin. Could be comedogenic3/5~1.6–2%est.
Ceteareth-20Helps oil and water mix together. Has some emollient properties2/5~2–2.4%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Cetyl alcohol~4.8–5.9%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Glycerin~3.9–4.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Dimethicone~3.2–3.9%
Key active
Irritation risk
Low
Works for
MoisturizingMattifying

A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish

More about Dimethicone
Butyrospermum parkii butter~2.4–2.9%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Ceteareth-20~2–2.4%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together. Has some emollient properties

More about Ceteareth-20
Isopropyl myristate~1.6–2%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin. Could be comedogenic

More about Isopropyl myristate
Soluble collagen~1.4–1.7%
Key active
Irritation risk
Low
Works for
Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Soluble collagen
Nicotiana benthamiana hexapeptide-40 sh-polypeptide-47~1.2–1.4%
Formula
Irritation risk
Low
More about Nicotiana benthamiana hexapeptide-40 sh-polypeptide-47
Acetyl hexapeptide-8~0.8–1.2%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl hexapeptide-8
Caulerpa lentillifera extract~0.7–1.05%
Formula
Irritation risk
Low
More about Caulerpa lentillifera extract
Aloe barbadensis leaf juice powder~0.5–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf juice powder
Oryza sativa bran extract~0.45–0.7%
Formula
Irritation risk
Low

Used to thicken the product consistency

More about Oryza sativa bran extract
Glycine max seed extract~0.45–0.65%
Formula
Irritation risk
Low
More about Glycine max seed extract
Daucus carota sativa root extract~0.35–0.65%
Formula
Irritation risk
Low
Works for
Anti-oxidation

Carrot extract. Might have anti-oxidant properties and be used to add orange color

More about Daucus carota sativa root extract
Chenopodium quinoa seed extract~0.35–0.65%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Chenopodium quinoa seed extract
Tocopherol~0.35–0.65%
Under-dosed
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Panax ginseng root extract~0.35–0.6%
Irritant · high
Irritation risk
High
Works for
Anti-inflammatoryAnti-oxidation

A plant extract that might have some anti-inflammatory properties, but solid evidence is lacking. It can be irritating

More about Panax ginseng root extract
Camellia sinensis leaf extract~0.3–0.55%
Key active
Irritation risk
Low
Works for
AntibacterialAnti-oxidationAnti-agingMoisturizingEvens skin toneAnti-blemish

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Oryza sativa extract~0.3–0.5%
Formula
Irritation risk
Low
Works for
MoisturizingAnti-oxidation

A grain extract that helps to create a thicker product consistency. It might have some anti-oxidant properties and help attract water to the upper layer of the skin

More about Oryza sativa extract
Rosmarinus officinalis leaf extract~0.2–0.4%
Irritant · high
Irritation risk
High
Works for
Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Pyrus malus fruit extract~0.2–0.4%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

Can have some moisturizing properties due to its sugar content

More about Pyrus malus fruit extract
Helianthus annuus extract~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Helianthus annuus extract
Cetearyl ethylhexanoate~0.25–0.45%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps soften the skin

More about Cetearyl ethylhexanoate
Phenoxyethanol~0.2–0.4%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Cetearyl phosphate~0.2–0.35%
Formula
Irritation risk
Low
More about Cetearyl phosphate
Glyceryl stearate~0.25–0.45%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together

More about Glyceryl stearate
Carbomer~0.2–0.35%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Xanthan gum~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Caprylyl glycol~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Sodium hydroxide~0.2–0.4%
Formula
Irritation risk
Low

Used to adjust the product's pH

More about Sodium hydroxide
Hexylene glycol~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Synthetic beeswax~0.2–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Synthetic beeswax
Ethylhexylglycerin~0.2–0.4%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Tetrasodium glutamate diacetate~0.2–0.35%
Formula
Irritation risk
Low

Helps stabilize the product formulation

More about Tetrasodium glutamate diacetate
Butylene glycol~0.2–0.35%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Pentylene glycol~0.25–0.45%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Parfum~0.15–0.3%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Citric acid~0.15–0.3%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Sodium citrate~0.15–0.3%
Irritant · medium
Irritation risk
Medium

Helps to control the skin's pH level. Maintains the skin's natural film of amino-lactic acids and oils. Helps to preserve products

More about Sodium citrate
Sodium benzoate~0.15–0.25%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Potassium sorbate~0.15–0.3%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Acetic acid~0.15–0.25%
Formula
Irritation risk
Low
More about Acetic acid
Linalool~0.1–0.15%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Linalool
Hexyl cinnamal~0.1–0.15%
Irritant · high
Irritation risk
High

A fragrance with jasmine smell. A likely irritant

More about Hexyl cinnamal
Ingredient list view

Water, Cetyl alcohol, Glycerin, Dimethicone, Butyrospermum parkii butter, Ceteareth-20, Isopropyl myristate, Soluble collagen, Nicotiana benthamiana hexapeptide-40 sh-polypeptide-47, Acetyl hexapeptide-8, Caulerpa lentillifera extract, Aloe barbadensis leaf juice powder, Oryza sativa bran extract, Glycine max seed extract, Daucus carota sativa root extract, Chenopodium quinoa seed extract, Tocopherol, Panax ginseng root extract, Camellia sinensis leaf extract, Oryza sativa extract, Rosmarinus officinalis leaf extract, Pyrus malus fruit extract, Helianthus annuus extract, Cetearyl ethylhexanoate, Phenoxyethanol, Cetearyl phosphate, Glyceryl stearate, Carbomer, Xanthan gum, Caprylyl glycol, Sodium hydroxide, Hexylene glycol, Synthetic beeswax, Ethylhexylglycerin, Tetrasodium glutamate diacetate, Butylene glycol, Pentylene glycol, Parfum, Citric acid, Sodium citrate, Sodium benzoate, Potassium sorbate, Acetic acid, Linalool, Hexyl cinnamal

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Advanced Clinicals
$17.99
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$31.99
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
ADVANCED CLINICALSCollagen + Peptide Body CreamYOUR PRODUCTMakariCeramide Collagen + Peptides Body Toning CreamMedix 5.5Collagen + Caviar Age Control MoisturizerAERINWaterlily Sun Body Cream
Match—71%62%56%
Price$17.99$29.00+$11.01—$15.00−$2.99
Shared key ingredients—12 of 1211 of 124 of 12
Key difference———Acetyl Glucosamine
Irritancy High High Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 12 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Dimethicone as a protective ingredient in topical medicationsjaad.org
  3. 3
    Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
  4. 4
    Vitamin E in dermatologyncbi.nlm.nih.gov
  5. 5
    Vitamin E and Skin Healthlpi.oregonstate.edu
  6. 6
    Ginseng in Dermatology: A Reviewncbi.nlm.nih.gov
ADVANCED CLINICALS Collagen + Peptide Body Cream
ADVANCED CLINICALSCollagen + Peptide Body Cream
Buy at Advanced Clinicals$17.99$31.99as of 10/22 00:02 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Advanced Clinicals$17.99$31.99as of 10/22 00:02 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.