Just used this combo first time last night, with no skin problems (no reaction)! I’m using prescription 15% azaleic acid (nightly), so I subbed the Face Theory 15% azaleic (in the database) for my prescription. I HAD USED EACH OF THESE PRODUCTS BEFORE, although a couple of them I hadn’t used for the past couple of weeks or longer. My goals when using actives are: 1) little to no irritation, and 2) effectiveness. Also (lightly) cleanse/ moisturise/ high-SPF face sunscreen every AM, with sunscreen reapplication throughout daylight hours. 🤓 — (Other than a few blackheads [nose], I do not have acne, or oily skin.