Product category
Spot treatments for acne blemishes
All productsTarget breakouts without guessing—filter spot treatments by proven actives and tolerance.
Filters
Efficacy score
How well do the ingredients match what the product promises?
Irritancy risk
Filter by how likely the formula is to cause irritation.
Safety filters
Exclude common irritants and allergens from your results.
376products
376products
Active filters
Suggested refinementsTap to narrow results.
Peter Thomas RothMicrodermabrasion Blackhead Acne MedicationEfficacy66/100
salicylic acidglycerinkaolin +3 actives
Anti-blemish Exfoliation +1
$90.00
St. IvesTea Tree Acne Control Spot TreatmentEfficacy100/100
niacinamidesalicylic acidglycerin +5 actives
Anti-blemish Exfoliation +1
Essential oils
Price unavailable
Ren SkincareNon-Drying Spot TreatmentEfficacy87/100
salicylic acidanhydroxylitolglycerin +2 actives
Anti-blemish Exfoliation +2
Alcohol
$20.00
Mario BadescuDrying PatchesEfficacy100/100
salicylic acidmadecassosideniacinamide +5 actives
Moisturizing Anti-blemish +4
Price unavailable
OriginsSuper Spot Remover Blemish Treatment GelEfficacy83/100
Mineral oilsalicylic acidpetrolatum +8 actives
Moisturizing Anti-blemish +1
Alcohol
$13.60
Tata HarperClarifying Spot SolutionEfficacy50/100
lactic acidglycerinSea buckthorn oil +4 actives
Moisturizing
Fragrance
Price unavailable
Image skincareCLEAR CELL clarifying acne spot treatmentEfficacy100/100
salicylic acidglycerinsaccharide isomerate +1 actives
Anti-blemish Exfoliation +1
$35.00
ShiseidoTreatments Waso: KOSHIRICE Calming Spot Treatmentsalicylic aciddimethiconedipotassium glycyrrhizate +2 actives
Moisturizing
Price unavailable
Peter Thomas RothAcne-Clear Invisible DotsEfficacy100/100
salicylic acidphytosphingosineepilobium angustifolium flower/leaf/stem extract +2 actives
Moisturizing Anti-blemish +3
Alcohol
Price unavailable
Etude HouseClear Complexion Willow Bark Spot TreatmentEfficacy75/100
Marshmallow root extractglycerinRosemary extract
Moisturizing
$18.00
Burt's BeesNatural Acne Solutions Maximum Strength Spot Treatment CreamEfficacy100/100
salicylic acidcaprylic/capric triglyceridedipotassium glycyrrhizate +5 actives
Anti-blemish Exfoliation +1
Fragrance
$9.99
Ren SkincareREN ClearCalm Non-Drying Acne Treatment GelEfficacy75/100
salicylic acidanhydroxylitolglycerin +2 actives
Anti-blemish Exfoliation +2
Alcohol
$30.00
ReplenixAcne Solutions Gly Sal 10-2 PadsEfficacy100/100
salicylic acidglycolic acid
Exfoliation Anti-blemish +2
Price unavailable
OriginsSuper Spot Remover™ Acne Treatment GelEfficacy75/100
salicylic acidcaffeineglycerin +4 actives
Anti-blemish Exfoliation +1
Alcohol
$20.00
ObagiSUZANOBAGIMD Cleansing WipesEfficacy100/100
trehalosedecyl glucosidehexylene glycol +2 actives
Cleansing
Price unavailable
MuradPost Acne Spot Lightening GelEfficacy75/100
glycolic aciddipotassium glycyrrhizateglycerin +5 actives
Anti-aging Anti-oxidation +4
Alcohol
Price unavailable
La Roche-PosayEffaclar 3-Step Anti Blemish SystemEfficacy62/100
niacinamidesalicylic acidcapryloyl salicylic acid +10 actives
Exfoliation Evens skin tone +1
FragranceAlcohol
$35.00
Derm InstituteCellular Brightening Spot TreatmentEfficacy16/100
retinyl palmitateascorbyl tetraisopalmitatehelianthus annuus seed oil unsaponifiables +8 actives
Moisturizing Anti-oxidation
Fragrance
$265.00
Dermelect CosmeceuticalsDermelect Beautone Enlightening Spot TreatmentEfficacy87/100
glycolic acidpanthenolcaprylic/capric triglyceride +4 actives
Exfoliation Moisturizing +3
Fragrance
Price unavailable