ZO Skin Health Peptide Facial Refining Concentrate
Works for
Anti-agingAcetyl octapeptide-3, Acetyl hexapeptide-8 + 3 moreMay help
“This next-generation anti-wrinkle peptide concentrate is powered by four cutting-edge peptide technologies that work synergistically to smooth lines, improve elasticity + restore facial volume.”
This product contains acetyl hexapeptide-8, acetyl octapeptide-3, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
MoisturizingSide benefit the brand mentions · Acetyl octapeptide-3, Acetyl hexapeptide-8 + 11 moreWorks well
“Volumizing Tripeptide: Supports hyaluronic acid production for fuller, plumper-looking skin”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
galactoarabinan, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: squalene, beta-sitosterol.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, acetyl octapeptide-3, palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine
Anti-oxidationSide benefit · Squalene, Laminaria digitata extract + 1 moreMay help
This product contains antioxidants (squalene) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.
Can it cause trouble?
Irritancy9 flagged ingredientsLow risk
Comedogenic2 ingredients rated 2 or more on the 0–5 pore-clogging scale2 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~40–60%
Glycerin~4–5.9%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinPropanediol~3–4.5%
- Irritation risk
- Low
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
More about PropanediolAcetyl octapeptide-3~2.4–3.7%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl octapeptide-3Acetyl hexapeptide-8~1.9–2.8%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine~1.5–2.2%
- Irritation risk
- Low
Palmitoyl dipeptide-5 diaminohydroxybutyrate~1.2–1.9%
- Irritation risk
- Low
Laminaria digitata extract~1.1–1.7%
- Irritation risk
- Low
- Comedogenicity
- 3/5
Seaweed extract that helps the skin to attract water and make it more smooth for touch. Also shows promise of anti-aging properties, but good research is lacking at the moment
More about Laminaria digitata extractOpuntia ficus-indica stem extract~0.85–1.3%
- Irritation risk
- Low
Tocopherol~0.5–1.15%
- Irritation risk
- Low
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
More about TocopherolCaprylyl glycol~0.35–0.85%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolHexylene glycol~0.15–0.65%
- Irritation risk
- Medium
Helps create a more spreadable product texture
More about Hexylene glycolSodium hyaluronate~0.1–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateGalactoarabinan~0.1–0.4%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin
More about GalactoarabinanSchizophyllan~0.1–0.35%
- Irritation risk
- Low
Beta-sitosterol~0.1–0.4%
- Irritation risk
- Low
A phytosterol that can support skin's barrier function and help the skin stay hydrated
More about Beta-sitosterolLecithin~0.1–0.45%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinHydrogenated phosphatidylcholine~0.1–0.4%
- Irritation risk
- Medium
Helps oil and water mix together
More about Hydrogenated phosphatidylcholineLysolecithin~0.1–0.4%
- Irritation risk
- Low
Lecithin derivative. It helps oil and water mix together and can enhance penetration of other ingredients. It helps soften the upper layer of the skin
More about LysolecithinCarbomer~0.05–0.3%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerXanthan gum~0.05–0.25%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumMagnesium chloride~0.05–0.2%
Disodium edta~0.05–0.15%
Phytic acid~0.05–0.2%
- Irritation risk
- Medium
An alpha-hydroxy acid (AHA), but is mostly used to stabilize product formulations in cosmetics
More about Phytic acidMaltodextrin~0.05–0.25%
- Irritation risk
- Low
Used to stabilize the product formulation and can help absorb oil
More about MaltodextrinSqualene~0.1–0.35%
- Irritation risk
- Low
- Comedogenicity
- 2/5
An oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast
More about SqualeneAminomethyl propanol~0.05–0.15%
Citric acid~0.05–0.15%
- Irritation risk
- Medium
Can work as an exfoliant but is typically used to adjust the product pH
More about Citric acidPhenoxyethanol~0.05–0.2%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolEthylhexylglycerin~0.05–0.15%
Sodium benzoate~0.05–0.15%
Potassium sorbate~0.05–0.15%
Ingredient list view
Water, Glycerin, Propanediol, Acetyl octapeptide-3, Acetyl hexapeptide-8, Palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, Palmitoyl dipeptide-5 diaminohydroxybutyrate, Laminaria digitata extract, Opuntia ficus-indica stem extract, Tocopherol, Caprylyl glycol, Hexylene glycol, Sodium hyaluronate, Galactoarabinan, Schizophyllan, Unknown, Beta-sitosterol, Lecithin, Hydrogenated phosphatidylcholine, Lysolecithin, Carbomer, Xanthan gum, Magnesium chloride, Disodium edta, Phytic acid, Maltodextrin, Squalene, Aminomethyl propanol, Citric acid, Phenoxyethanol, Ethylhexylglycerin, Sodium benzoate, Potassium sorbate
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| ZO Skin HealthPeptide Facial Refining ConcentrateYOUR PRODUCT | NourishMaxMulti Peptide Serum | PotentLiftAdvanced Multi Peptide Complex Serum | FormulystAnti-Wrinkle Peptide Serum | |
|---|---|---|---|---|
| Match | — | 50% | 50% | 49% |
| Price | $265.00 | $49.00−$216.00 | $39.00−$226.00 | — |
| Shared key ingredients | — | 4 of 9 | 4 of 9 | 4 of 9 |
| Key difference | — | Pentapeptide-18 | Pentapeptide-18 | Pentapeptide-18 |
| Irritancy | Low | Low | Low | Low |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: Luzern Laboratories Luzern WE3 Triple Action Serum Wrinkle CorrectorGood Molecules Super Peptide Serum
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 12 studies and safety reviews.
- 1
- 2Vitamin E in dermatologyncbi.nlm.nih.gov
- 3Vitamin E and Skin Healthlpi.oregonstate.edu
- 4Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
- 5
- 6Safety Assessment of Phytosterols as Used in Cosmeticscir-safety.org
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