Works for:
based on ingredients and %- Moisturizing
- Anti-aging
Doesn't work for:
based on ingredients and %- Evens skin tone
Can it cause trouble?
- Irritation risk: medium
- Comedogenic risk ingredients: 0
Key actives
Product Summary
"Twelve Natural Skincare - Twelve B12 Calm Serum" is effective for: Moisturizing
This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.
Ingredient callouts
- An effective concentration of Panthenol (pro-vitamin B5) - about 2.80% - 4.10%. Panthenol helps strengthen the skin barrier, improve hydration and reduce inflammation in skin.
- Humectants (histidine 0.10% - 0.40%, alanine 0.30% - 0.70%, glycine 0.35% - 0.80%, pca 0.35% - 0.85%, aspartic acid 0.40% - 0.90%, arginine 0.45% - 1.10%, sodium lactate 1.00% - 1.50%, sodium hyaluronate 1.20% - 1.80%, pca 1.40% - 2.10%, glycerin 2.10% - 3.20% and panthenol 2.80% - 4.10%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
Price
The product retails for 56.00£ in the United Kingdom.
For a detailed price comparison: click here.
Moisturizing
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
alanine, arginine.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, caprylyl glycol.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: panthenol
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
A marine extract that helps attract water to the upper layer of the skin. It is claimed to have anti-inflammatory properties but research is lacking
Can support skin barrier function and reduce inflammation in skin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function
Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Naturally present in skin and helps to attract water to its upper layer
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Helps preserve products and creates a nice product texture
Anti-aging
This product contains aspartic acid, threonine. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
Evens skin tone
What does the product description say?
96% of users in a trial stated their skin felt calmer after using the serum.Ideal for use after sun exposure, cosmetic procedures, or any time the skin feels compromised, this non-irritating serum helps promote a more even-toned, resilient, and comforted complexion.Suitable for sensitive, reactive, redness-prone.30ml
Source: Content
This product contains ingredients (alanine) that could help reduce hyperpigmentation (for example, post-acne marks or age spots) in theory, but there is not enough evidence that they actually work.
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Evens skin tone |
Total Promises Fulfilled score: 50/100.
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Potential irritants
Comedogenic ingredients
No comedogenic ingredients detected
User reviews (0)
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 Twelve Natural Skincare Twelve B12 Calm Serum | Current | $56.00 | |
Skintegra Lunar Concentrate Serum | 67% | $17.00 | |
Summer Fridays Dream Oasis Hydration Serum | 65% | $42.00 | |
 MEDI-PEEL Luminous Silk Oil Serum | 61% | $30.20 | |
 BLANC DIVA Rebirth Serum | 60% | $36.73 | |
 Medik8 Hydr8 B5 Intense Hyaluronic Acid Serum | 60% | $69.00 |
Key Actives
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"
Can support skin barrier function and reduce inflammation in skin
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
A marine extract that helps attract water to the upper layer of the skin. It is claimed to have anti-inflammatory properties but research is lacking
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Naturally present in skin and helps to attract water to its upper layer
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
Naturally present in skin and helps to attract water to its upper layer
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function
Potential irritants
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Helps preserve products and creates a nice product texture
Comedogenic ingredients
We couldn't find any comedogenic ingredients in this product
All ingredients
A marine extract that helps attract water to the upper layer of the skin. It is claimed to have anti-inflammatory properties but research is lacking
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
Helps attract water to the upper layer of the skin and can help improve skin barrier function
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Naturally present in skin and helps to attract water to its upper layer
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
Can support skin barrier function and reduce inflammation in skin
An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin
An amino-acid that helps increase skin hydration and might help to slightly improve skin firmness, potentially reducing lines and wrinkles
Naturally present in skin and helps to attract water to its upper layer
Helps to attract water to the upper layer of the skin and can help restore the skin barrier function
An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking
Consists of remains of dead bacteria cells. Is likely helpful in attracting water to the upper layer of the skin. Might be helpful in reducing inflammation and neutralizing free radicals in skin. It is claimed to be a "DNA repair enzyme"
An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles
An amino acid that can help attract water to the upper layer of the skin and support skin's barrier function
Helps preserve products and creates a nice product texture
Ingredient list view
Water, Alteromonas ferment extract, Propanediol, Panthenol, Glycerin, Citrus limon peel powder, Pca, Sodium hyaluronate, Sodium lactate, Cyanocobalamin, Arginine, Aspartic acid, Pca, Glycine, Alanine, Citrus aurantifolia peel powder, Valine, Proline, Micrococcus lysate, Threonine, Isoleucine, Histidine, Phenylalanine, Caprylyl glycol, Sclerotium gum, Ethylhexylglycerin, Levulinic acid
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Glycerol and the skin: holistic approach to its origin and functions
- Hyaluronic acid: A key molecule in skin aging
- Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin care
- Topical vitamin B12--a new therapeutic approach in atopic dermatitis-evaluation of efficacy and tolerability in a randomized placebo-controlled multicentre clinical trial
- Superiority of a vitamin B12-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis
- Acetyl aspartic acid, a novel active ingredient, demonstrates potential to improve signs of skin ageing: from consumer need to clinical proof
- In vivo topical application of acetyl aspartic acid increases fibrillin-1 and collagen IV deposition leading to a significant improvement of skin firmness
- Effect of Topical Application of Glycine and Proline on Recalcitrant Leg Ulcers of Prolidase Deficiency
- Functional glycine receptor in cultured human keratinocytes
- Combination of amino acids reduces pigmentation in B16F0 melanoma cells
- Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin
- Local rhamnosoft, ceramides and L‐isoleucine in atopic eczema: a randomized, placebo controlled trial
- Histidine and/or Histidine Derivative for the Treatment of Inflammatory Skin Diseases
- Safety Assessment of α-Amino Acids as Used in Cosmetics