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SkinMedica GlyPro Antioxidant Serum
SkinMedica

SkinMedica GlyPro Antioxidant Serum

Efficacy100/100IrritancyMedium
See all ingredients

Works for

Moisturizing
Urea, Glycerin + 16 more
Works well
What the product description says
“This silky serum hydrates and helps renovate the skin, revealing a more vibrant, luminous texture.”
Source: Skinstore

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: cyclomethicone, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: phenyl trimethicone, cyclomethicone.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: urea

UreaHero· HumectantEffect: HighNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.3–0.55%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3–3.7%
Phenyl trimethiconeKey active· OcclusiveEffect: HighA type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture~2.3–2.9%
CyclomethiconeKey active· Humectant, EmollientEffect: HighA type of silicone that leaves a nice silky finish on the skin and can help soften its upper layer~1.9–2.3%
Cassia angustifolia seed polysaccharideKey activeEffect: HighHelps attract water to the upper layer of the skin. Is sometimes referred to as "natural" hyaluronic acid (even though hyaluronic acid is not unnatural and is present in human skin)~1.6–1.9%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.3–0.6%
TrehaloseKey active· HumectantEffect: HighA sugar that attracts water to the upper layer of the skin~0.3–0.5%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~0.3–0.55%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.25–0.45%
MannitolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.25–0.4%
Isononyl isononanoate· Emollient, OcclusiveEffect: LowForms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness~4.2–5.2%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.65–1%
Polyquaternium-51Effect: LowAn emollient that helps create a nice silky finish on the skin~0.3–0.5%
Polysilicone-11Effect: LowA silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel~0.25–0.45%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.2–0.4%
Aloe barbadensis leaf extractEffect: Low, below effective doseTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin~0.45–0.7%
LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.25–0.5%
Yeast extractUnder-dosedHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.25–0.45%
Evens skin tone
Glycolic acid, Punica granatum extract + 2 more
Works well
What the product description says
“Reduces the appearance of hyperpigmentation.”
Source: Skinstore

This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: glycolic acid

The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: glycyrrhiza glabra root extract, punica granatum extract.

Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~4.9–6%
Punica granatum extractEffect: LowA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective~0.5–0.7%
Glycyrrhiza glabra root extractEffect: LowA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals~0.45–0.65%
Yeast extractEffect: Low, below effective doseHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.25–0.45%
Anti-oxidation
Side benefit · Camellia oleifera leaf extract, Punica granatum extract + 3 more
Works well

This product contains antioxidants (camellia oleifera leaf extract) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

The following ingredients - punica granatum extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.

Camellia oleifera leaf extractKey activeEffect: HighA plant extract that can help neutralize free radicals and reduce inflammation, even though it is not usually used in sufficient concentration in cosmetics~0.55–0.8%
Punica granatum extractKey activeEffect: MediumA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective~0.5–0.7%
Glycyrrhiza glabra root extractEffect: LowA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals~0.45–0.65%
Olea europaea leaf extractEffect: LowA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing~0.2–0.4%
Yeast extractUnder-dosedHelps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin~0.25–0.45%
Anti-aging
Side benefit · Glycolic acid
Works well

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains glycolic acid.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~4.9–6%
Exfoliation
Side benefit · Glycolic acid, Urea
Works well

This product can help exfoliate the skin. In other words, it helps break down the bonds between dead cells on the surface of the skin and speed up the skin turnover. Skin often appears softer and brighter after exfoliation, but overdoing it can result in disrupted skin barrier. The following ingredient is doing the exfoliating job in this product: glycolic acid.

Glycolic acidKey activeEffect: HighAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid~4.9–6%
UreaKey activeEffect: MediumNaturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations~0.3–0.55%

Can it cause trouble?

Irritancy
15 flagged ingredients
Medium risk
We flagged 15 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Glycolic acidAn alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acidHigh~4.9–6%est.
Anthemis nobilis flower extractA plant extract that one one hand, can contain compounds that can help calm down skin irritation, but, on the other hand, its other compounds (especially fragrant ones) can themselves be irritatingHigh~0.35–0.65%est.
TriacetinUsed to dissolve other ingredientsHigh~0.15–0.3%est.
Cassia angustifolia seed polysaccharideHelps attract water to the upper layer of the skin. Is sometimes referred to as "natural" hyaluronic acid (even though hyaluronic acid is not unnatural and is present in human skin)Medium~1.6–1.9%est.
C12-20 alkyl glucosideHelps water and oil mix togetherMedium~0.95–1.15%est.
Punica granatum extractA plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effectiveMedium~0.5–0.7%est.
Glycyrrhiza glabra root extractA plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicalsMedium~0.45–0.65%est.
Aloe barbadensis leaf extractTraditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skinMedium~0.45–0.7%est.
Olea europaea leaf extractA plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missingMedium~0.2–0.4%est.
Hexylene glycolHelps create a more spreadable product textureMedium~0.2–0.35%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.2–0.4%est.
Ammonium hydroxideHelps adjust the product pHMedium~0.15–0.25%est.
Disodium edtaStabilizes the product formulationMedium~0.15–0.25%est.
EthylhexylglycerinA preservativeMedium~0.15–0.25%est.
Potassium sorbateA preservativeMedium~0.1–0.25%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~0.3–0.55%est.
Alternatives
The closest match we found
Hyaluronic Marine Hydration Booster Serum | Dr. Dennis Gross
Dr Dennis Gross Hyaluronic Marine Hydration Booster Serum | Dr. Dennis Gross
Closest match53% match
$20.00
View all alternatives

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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycolic acid~4.9–6%
Key activeIrritant · high
Irritation risk
High
Works for
Anti-agingEvens skin toneExfoliationAnti-blemish

An alpha-hydroxy acid (AHA) that helps to remove the dead skin cells on the surface of the skin reveling a more even, smoother complexation. It is also able to stimulate collagen production with long-term use. Could help to reduce pore congestion. It can be irritating to the skin. Apply sunscreen daily if using products with glycolic acid

More about Glycolic acid
Isononyl isononanoate~4.2–5.2%
Formula
Irritation risk
Low
Works for
Moisturizing

Forms a protective film on the surface of the skin to prevent moisture loss. Gives a velvety feel to products while reducing tackiness

More about Isononyl isononanoate
Glycerin~3–3.7%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Phenyl trimethicone~2.3–2.9%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of silicone that can decrease loss of moisture from the skin surface. It helps create a nice product texture

More about Phenyl trimethicone
Cyclomethicone~1.9–2.3%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of silicone that leaves a nice silky finish on the skin and can help soften its upper layer

More about Cyclomethicone
Cassia angustifolia seed polysaccharide~1.6–1.9%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps attract water to the upper layer of the skin. Is sometimes referred to as "natural" hyaluronic acid (even though hyaluronic acid is not unnatural and is present in human skin)

More about Cassia angustifolia seed polysaccharide
Bis-hydroxyethoxypropyl dimethicone~1.4–1.7%
Formula
Irritation risk
Low
More about Bis-hydroxyethoxypropyl dimethicone
C14-22 alcohols~1.1–1.4%
Formula
Irritation risk
Low

A non-drying alcohol that helps stabilize product formulations

More about C14-22 alcohols
C12-20 alkyl glucoside~0.95–1.15%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about C12-20 alkyl glucoside
Butylene glycol~0.65–1%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Camellia oleifera leaf extract~0.55–0.8%
Key active
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatory

A plant extract that can help neutralize free radicals and reduce inflammation, even though it is not usually used in sufficient concentration in cosmetics

More about Camellia oleifera leaf extract
Punica granatum extract~0.5–0.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Anti-oxidationEvens skin tone

A plant extract that can help neutralize free radicals in skin and even out the skin tone, but is typically used in products in a concentration that is too low to be effective

More about Punica granatum extract
Glycyrrhiza glabra root extract~0.45–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Reduces rednessAnti-oxidationAnti-inflammatoryEvens skin toneAntibacterial

A plant extract that can help lighten the skin and calm down inflammation. Might be helpful in neutralizing free radicals

More about Glycyrrhiza glabra root extract
Anthemis nobilis flower extract~0.35–0.65%
Irritant · high
Irritation risk
High
Works for
Reduces irritationAnti-inflammatory

A plant extract that one one hand, can contain compounds that can help calm down skin irritation, but, on the other hand, its other compounds (especially fragrant ones) can themselves be irritating

More about Anthemis nobilis flower extract
Aloe barbadensis leaf extract~0.45–0.7%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Traditionally used to treat sunburns, dermatitis and inflammation, but evidence for its effectiveness is lacking. The extract can contain humectants that help attract water into the skin

More about Aloe barbadensis leaf extract
Stevia rebaudiana leaf/stem extract~0.4–0.6%
Formula
Irritation risk
Low
More about Stevia rebaudiana leaf/stem extract
Sodium pca~0.3–0.6%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Urea~0.3–0.55%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingExfoliation

Naturally present in skin (urea makes up about 7% of natural moisturizing factors in skin). Attracts water to the upper layer of the skin. Also has a positive effect on the skin barrier beyond the humectant action. Can enhance penetration of other ingredients. Is an exfoliating ingredient when used in high concentrations

More about Urea
Trehalose~0.3–0.5%
Key active
Irritation risk
Low
Works for
Moisturizing

A sugar that attracts water to the upper layer of the skin

More about Trehalose
Polyquaternium-51~0.3–0.5%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps create a nice silky finish on the skin

More about Polyquaternium-51
Sodium hyaluronate~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Xanthan gum~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Cetearyl alcohol~0.3–0.55%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Ceteareth-33~0.3–0.6%
Formula
Irritation risk
Low
Works for
Cleansing
More about Ceteareth-33
Mannitol~0.25–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin

More about Mannitol
Cyclodextrin~0.25–0.45%
Formula
Irritation risk
Low

A type of sugar that is used to support delivery of active ingredients and can enhance their penetration into the skin without disrupting the skin's barrier

More about Cyclodextrin
Yeast extract~0.25–0.45%
Under-dosed
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryAnti-oxidationReduces irritationEvens skin tone

Helps attract water to the upper layer of the skin and might have some anti-oxidant and skin lightening properties. It can help calm down inflammation in skin

More about Yeast extract
Disodium succinate~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing
More about Disodium succinate
Olea europaea leaf extract~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing

More about Olea europaea leaf extract
Polysilicone-11~0.25–0.45%
Formula
Irritation risk
Low
Works for
MattifyingMoisturizing

A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel

More about Polysilicone-11
Lecithin~0.25–0.5%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin
Polyacrylate-13~0.25–0.45%
Formula
Irritation risk
Low

Used to create a thicker product consistency and stabilize the product formulation

More about Polyacrylate-13
Polyisobutene~0.25–0.45%
Formula
Irritation risk
Low

Used to improve the product consistency

More about Polyisobutene
Polysorbate 20~0.25–0.45%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Polysorbate 20
Hexylene glycol~0.2–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol
Caprylyl glycol~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Triacetin~0.15–0.3%
Irritant · high
Irritation risk
High

Used to dissolve other ingredients

More about Triacetin
Ammonium hydroxide~0.15–0.25%
Irritant · medium
Irritation risk
Medium

Helps adjust the product pH

More about Ammonium hydroxide
Disodium edta~0.15–0.25%
Irritant · medium
Irritation risk
Medium

Stabilizes the product formulation

More about Disodium edta
Ethylhexylglycerin~0.15–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Phenoxyethanol~0.15–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Potassium sorbate~0.1–0.25%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Ingredient list view

Water, Glycolic acid, Isononyl isononanoate, Glycerin, Phenyl trimethicone, Cyclomethicone, Cassia angustifolia seed polysaccharide, Bis-hydroxyethoxypropyl dimethicone, C14-22 alcohols, C12-20 alkyl glucoside, Butylene glycol, Camellia oleifera leaf extract, Punica granatum extract, Glycyrrhiza glabra root extract, Anthemis nobilis flower extract, Aloe barbadensis leaf extract, Stevia rebaudiana leaf/stem extract, Sodium pca, Urea, Trehalose, Polyquaternium-51, Sodium hyaluronate, Xanthan gum, Cetearyl alcohol, Ceteareth-33, Mannitol, Cyclodextrin, Yeast extract, Disodium succinate, Olea europaea leaf extract, Polysilicone-11, Lecithin, Polyacrylate-13, Polyisobutene, Polysorbate 20, Hexylene glycol, Caprylyl glycol, Triacetin, Ammonium hydroxide, Disodium edta, Ethylhexylglycerin, Phenoxyethanol, Potassium sorbate

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
SkinMedicaGlyPro Antioxidant SerumYOUR PRODUCTDr Dennis GrossHyaluronic Marine Hydration Booster Serum | Dr. Dennis GrossBABORLIFTING RX Lift Serumskintific2% SALICYLIC ACID ANTI ACNE SERUM
Match—53%53%51%
Price—$20.00——
Shared key ingredients—5 of 145 of 144 of 14
Key difference—RetinolNiacinamideSalicylic Acid
Irritancy Medium Medium Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.

  1. 1
    Photoprotective and antiinflammatory effects of topical glycolic acidncbi.nlm.nih.gov
  2. 2
    Glycolic acid peel therapy – a current reviewncbi.nlm.nih.gov
  3. 3
    Dual Effects of Alpha-Hydroxy Acids on the Skinmdpi.com
  4. 4
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  5. 5
    Safety Assessment of Polysaccharide Gums as Used in Cosmeticscir-safety.org
  6. 6
    Anaphylaxis Due to Senna (Cassia angustifolia)jiaci.org
SkinMedica GlyPro Antioxidant Serum
SkinMedicaGlyPro Antioxidant Serum
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