Perricone MD Treatments Pre:Empt Skin Perfecting Serum
Works for
MoisturizingPalmitoyl tripeptide-5, Glycerin + 4 moreWorks well
“Perricone’s patent-pending Nrf2 Antioxidant Support Complex helps improve skin’s natural surface barrier and preserve smooth, refined, hydrated and youthful-looking skin.”
This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": glycerin, caprylyl glycol.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tripeptide-5
Anti-agingPalmitoyl tripeptide-5, Epigallocatechin gallatyl glucoside + 6 moreMay help
“Perricone MD, Treatments Drench skin with powerful antioxidants in this potent, silky-feeling treatment featuring the highest concentration of Nrf2 Antioxidant Support Complex to help protect against the natural oxidative stress caused by premature ageing.”
This product contains epigallocatechin gallatyl glucoside, palmitoyl tripeptide-5. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.
Anti-oxidationSide benefit · Thioctic acid, Tetrahydrodemethoxydiferuloylmethane + 7 moreWorks well
This product contains antioxidants (epigallocatechin gallatyl glucoside, thioctic acid) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
The following ingredients - tetrahydrobisdemethoxydiferuloylmethane, tetrahydrodemethoxydiferuloylmethane, tetrahydrodiferuloylmethane also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.
Can it cause trouble?
Irritancy4 strong irritants: Parfum, Amyl cinnamal + 2 more — patch-test recommendedHigh risk
ComedogenicClean of flagged comedogenic ingredientsNone flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~40–60%
Hexylene glycol~6–9%
- Irritation risk
- Medium
Helps create a more spreadable product texture
More about Hexylene glycolGlycerin~3.5–5.3%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinIsohexadecane~2.8–4.1%
- Irritation risk
- Low
Improves the texture of the product and helps soften the skin. Helps oil and water mix together and can be used as a cleansing agent
More about IsohexadecanePolysorbate 20~2–3%
Dimethyl mea~1.7–2.5%
- Irritation risk
- Low
Thioctic acid~1.4–2.1%
Tetrahexyldecyl ascorbate~1.2–1.8%
- Irritation risk
- Medium
Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.
More about Tetrahexyldecyl ascorbatePalmitoyl tripeptide-5~1–1.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-5Acetyl tyrosine~0.6–1.4%
- Irritation risk
- Low
Lepidium sativum sprout extract~0.5–1.1%
- Irritation risk
- Low
Olea europaea leaf extract~0.4–0.9%
- Irritation risk
- Medium
A plant extract that might have some anti-oxidant and anti-inflammatory properties but evidence for effectiveness in skin is missing
More about Olea europaea leaf extractMagnesium ascorbyl phosphate~0.35–0.85%
- Irritation risk
- Medium
A derivative of vitamin C that is more stable, but less bioavailable than the pure form of vitamin C. It does not penetrate the skin well, but has been shown to convert to pure vitamin C once in skin. It can be helpful in stimulating collagen production and lightening the skin tone, but the required concentration is likely to be very high
More about Magnesium ascorbyl phosphateTetrahydrodemethoxydiferuloylmethane~0.35–0.8%
- Irritation risk
- High
An anti-oxidant derived from curcumin (naturally present in tumeric). Is a part of the tetrahydrocurcuminoids complex (THC). The complex might be helpful in neutralizing free radicals in skin and possibly help even out the skin tone. Can be irritating
More about TetrahydrodemethoxydiferuloylmethaneEpigallocatechin gallatyl glucoside~0.3–0.7%
- Irritation risk
- Low
A synthetic version of green tea polyphenol that helps neutralize free radicals in skin
More about Epigallocatechin gallatyl glucosideTocopheryl acetate~0.2–0.8%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateTetrahydrodiferuloylmethane~0.2–0.75%
- Irritation risk
- High
An anti-oxidant derived from curcumin (naturally present in tumeric). Is a part of the tetrahydrocurcuminoids complex (THC). The complex might be helpful in neutralizing free radicals in skin and possibly help even out the skin tone. Can be irritating
More about TetrahydrodiferuloylmethaneTetrahydrobisdemethoxydiferuloylmethane~0.15–0.7%
- Irritation risk
- High
An anti-oxidant derived from curcumin (naturally present in tumeric). It might be helpful in neutralizing free radicals in skin and possibly help even out the skin tone. Can be irritating
More about TetrahydrobisdemethoxydiferuloylmethaneLecithin~0.15–0.6%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinCarbomer~0.1–0.45%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerDisodium edta~0.1–0.4%
Sorbitol~0.1–0.4%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin and improves the product texture
More about SorbitolCaprylyl glycol~0.1–0.4%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolPhenoxyethanol~0.05–0.25%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolParfum~0.05–0.2%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumAmyl cinnamal~0.05–0.15%
- Irritation risk
- High
Hydroxycitronellal~0.05–0.1%
- Irritation risk
- High
A fragrance. A likely allergen and can be irritating
More about HydroxycitronellalLinalool~0.01–0.1%
Ingredient list view
Water, Hexylene glycol, Glycerin, Isohexadecane, Polysorbate 20, Dimethyl mea, Thioctic acid, Tetrahexyldecyl ascorbate, Palmitoyl tripeptide-5, Acetyl tyrosine, Lepidium sativum sprout extract, Olea europaea leaf extract, Magnesium ascorbyl phosphate, Tetrahydrodemethoxydiferuloylmethane, Epigallocatechin gallatyl glucoside, Tocopheryl acetate, Tetrahydrodiferuloylmethane, Tetrahydrobisdemethoxydiferuloylmethane, Lecithin, Carbomer, Disodium edta, Sorbitol, Caprylyl glycol, Phenoxyethanol, Parfum, Amyl cinnamal, Hydroxycitronellal, Linalool
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Perricone MDTreatments Pre:Empt Skin Perfecting SerumYOUR PRODUCT | Image skincareIMAGE MD restoring youth repair serum | Kate Ryan SkincareVitamin C Daytime Repair Serum | Allies of SkinPeptides & Antioxidants Firming Daily Treatment GWP | |
|---|---|---|---|---|
| Match | — | 54% | 50% | 48% |
| Price | — | $112.00 | — | — |
| Shared key ingredients | — | 3 of 8 | 5 of 8 | 6 of 8 |
| Key difference | — | Glycolic Acid | Niacinamide | Niacinamide |
| Irritancy | High | High | Medium | Medium |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: SKINCITY skincare Multi Action Serummarie veronique C-Therapy Serum
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 9 studies and safety reviews.
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- 4
- 5
- 6Topical L-ascorbic acid: percutaneous absorption studiesncbi.nlm.nih.gov
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