Perricone MD Cold Plasma Plus+ Lip Therapy | PerriconeMD

Perricone MD Cold Plasma Plus+ Lip Therapy | PerriconeMD

Efficacy87/100IrritancyMedium
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Works for

2 of 2 advertised claims delivered

Moisturizing
Palmitoyl tripeptide-1, Ricinus communis seed oil + 20 more
Strong evidence
What the product description says
“Deeply nourishing and hydrating, it uses a proprietary liquid crystal delivery system for faster absorption of key ingredients into skin's surface for visibly softer, fuller and more supple lips.”
Source: Perricone MD

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: sodium hyaluronate, butylene glycol.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: beeswax, cocos nucifera oil.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: palmitoyl tripeptide-1

Ricinus communis seed oilKey active· Emollient, OcclusiveEffect: HighA plant oil that can help soften the skin. It might be helpful in calming down inflammation, but solid research is lacking. Is often used in lip products to create the needed product consistency~3.9–5.8%
Simmondsia chinensis seed oilKey active· Emollient, OcclusiveEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~4.6–7%
Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.15–0.55%
Astrocaryum murumuru seed butterKey active· EmollientEffect: HighHelps soften the upper layer of the skin. Could be comedogenic due to the myrisic acid content~0.5–1.2%
Cocos nucifera oilKey active· Emollient, OcclusiveEffect: HighAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic~22–33%
Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~0.35–0.8%
Helianthus annuus extractKey active· EmollientEffect: HighHelps soften the upper layer of the skin~0.35–0.75%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~2.9–4.4%
BeeswaxKey active· Emollient, OcclusiveEffect: HighForms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen~5.3–7.9%
Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.65%
Ethylhexyl palmitateKey active· EmollientEffect: MediumAn emollient that helps soften the skin and create a nice product texture~1.1–1.6%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.4–0.95%
Tribehenin· EmollientEffect: LowUsed to create a thicker product consistency and soften the upper layer of the skin~0.35–0.8%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.35–0.8%
Octyldodecanol· EmollientEffect: LowAn emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation~0.3–0.7%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.15–0.7%
Propylene carbonateEffect: LowIs used to dissolve other ingredients and create nice product texture~0.15–0.7%
Lactic acidUnder-dosedEffect: HighAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.15–0.65%
Butyrospermum parkii butterUnder-dosedEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.45–1.1%
Argania spinosa kernel oilUnder-dosedEffect: HighAn emollient that helps soften the upper layer of the skin. Might have some weak anti-oxidant properties~0.6–1.35%
NiacinUnder-dosedEffect: HighA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.1–0.4%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.75%
Anti-aging
Palmitoyl tripeptide-1, Butyrospermum parkii butter + 4 more
Moderate evidence
What the product description says
“This multi-tasking powerhouse targets and dramatically improves the appearance of vertical lip lines, loss of volume, lipstick feathering, lip discoloration and dry, rough texture.”
Source: Perricone MD

This product contains palmitoyl tripeptide-1. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~0.15–0.65%
Lactic acidUnder-dosedEffect: MediumAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)~0.15–0.65%
NiacinUnder-dosedEffect: MediumA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect~0.1–0.4%
Butyrospermum parkii butterEffect: Low, below effective doseA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.45–1.1%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.75%
Ascorbyl palmitateEffect: Low, below effective doseBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.~0.05–0.3%

Can it cause trouble?

Irritancy
2 strong irritants: Rosmarinus officinalis leaf extract, Methyl nicotinate
Medium risk
We flagged 18 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.15–0.65%est.
Methyl nicotinateCauses redness and irritation in skin. Is often added to lip roducts to create a temporary plumping effect. Is likely to have a negative effect on skin's barrier functionHigh~0.15–0.6%est.
NiacinA form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effectHigh~0.1–0.4%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~4.6–7%est.
Ricinus communis seed oilA plant oil that can help soften the skin. It might be helpful in calming down inflammation, but solid research is lacking. Is often used in lip products to create the needed product consistencyMedium~3.9–5.8%est.
Polyhydroxystearic acidUsed to create a thicker product consistency and stabilize the formulationMedium~1.5–2.3%est.
Acrylates copolymerUsed to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistencyMedium~1.3–1.9%est.
Argania spinosa kernel oilAn emollient that helps soften the upper layer of the skin. Might have some weak anti-oxidant propertiesMedium~0.6–1.35%est.
Astrocaryum murumuru seed butterHelps soften the upper layer of the skin. Could be comedogenic due to the myrisic acid contentMedium~0.5–1.2%est.
1,2-hexanediolA preservativeMedium~0.35–0.8%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.4–0.95%est.
PhosphatidylcholineUsed to enhance the delivery of other ingredientsMedium~0.35–0.85%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~0.35–0.8%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.35–0.8%est.
Lactic acidAn exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)Medium~0.15–0.65%est.
CaffeineMight be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyesMedium~0.1–0.4%est.
Ascorbyl palmitateBeing a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.Medium~0.05–0.3%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.05–0.25%est.
Comedogenic
4 ingredients rated 2 or more on the 0–5 pore-clogging scale
4 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Cocos nucifera oilAn emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic3/5~22–33%est.
Ethylhexyl palmitateAn emollient that helps soften the skin and create a nice product texture3/5~1.1–1.6%est.
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.45–1.1%est.
Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~0.35–0.8%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Cocos nucifera oil~22–33%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient. Found to be as effective as a moisturizer for dry skin as mineral oil. Could be comedogenic

More about Cocos nucifera oil
Beeswax~5.3–7.9%
Key active
Irritation risk
Low
Works for
Moisturizing

Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen

More about Beeswax
Simmondsia chinensis seed oil~4.6–7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Ricinus communis seed oil~3.9–5.8%
Key activeIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-inflammatory

A plant oil that can help soften the skin. It might be helpful in calming down inflammation, but solid research is lacking. Is often used in lip products to create the needed product consistency

More about Ricinus communis seed oil
Helianthus annuus seed oil~2.9–4.4%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Polyethylene~2.2–3.3%
Formula
Irritation risk
Low

Used to thicken the product's texture

More about Polyethylene
Polyhydroxystearic acid~1.5–2.3%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to create a thicker product consistency and stabilize the formulation

More about Polyhydroxystearic acid
Acrylates copolymer~1.3–1.9%
Irritant · medium
Irritation risk
Medium

Used to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistency

More about Acrylates copolymer
Ethylhexyl palmitate~1.1–1.6%
Key activeComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
Moisturizing

An emollient that helps soften the skin and create a nice product texture

More about Ethylhexyl palmitate
Vanillin~0.85–1.25%
Formula
Irritation risk
Low
More about Vanillin
Argania spinosa kernel oil~0.6–1.35%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
MoisturizingAnti-oxidation

An emollient that helps soften the upper layer of the skin. Might have some weak anti-oxidant properties

More about Argania spinosa kernel oil
Astrocaryum murumuru seed butter~0.5–1.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps soften the upper layer of the skin. Could be comedogenic due to the myrisic acid content

More about Astrocaryum murumuru seed butter
Butyrospermum parkii butter~0.45–1.1%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Oryza sativa bran extract~0.35–0.85%
Formula
Irritation risk
Low

Used to thicken the product consistency

More about Oryza sativa bran extract
1,2-hexanediol~0.35–0.8%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Caprylyl glycol~0.4–0.95%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Phosphatidylcholine~0.35–0.85%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to enhance the delivery of other ingredients

More about Phosphatidylcholine
Tocopherol~0.3–0.75%
Formula
Irritation risk
Low
Works for
Anti-oxidationMoisturizingAnti-inflammatoryAnti-aging

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Glycine soja oil~0.35–0.8%
Key activeComedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil
Tribehenin~0.35–0.8%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a thicker product consistency and soften the upper layer of the skin

More about Tribehenin
Rosmarinus officinalis leaf extract~0.15–0.65%
Irritant · high
Irritation risk
High
Works for
Anti-blemishAntibacterialAnti-oxidation

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract
Octyldodecanol~0.3–0.7%
Formula
Irritation risk
Low
Works for
Moisturizing

An emollient that helps to soften the skin and create a pleasant product texture and stabilize the formulation

More about Octyldodecanol
Sorbitan isostearate~0.2–0.7%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan isostearate
Helianthus annuus extract~0.35–0.75%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Helianthus annuus extract
Silica dimethyl silylate~0.3–0.75%
Formula
Irritation risk
Low

Used to create a thicker product consistency

More about Silica dimethyl silylate
Quaternium-90 bentonite~0.15–0.7%
Formula
Butylene glycol~0.15–0.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Pentylene glycol~0.35–0.8%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Lactic acid~0.15–0.65%
Under-dosedIrritant · medium
Irritation risk
Medium
Works for
Evens skin toneMoisturizingExfoliationAnti-aging

An exfoliating and moisturizing alpha-hydroxy acid (AHA). Typically causes less irritation than other AHAs, for example, glycolic acid. At high concentrations (about 15%), lactic acid can help reduce lines and wrinkles. Recent studies show that lactic acid can support the "good" bacteria living on skin's surface (healthy skin microbiome)

More about Lactic acid
Methyl nicotinate~0.15–0.6%
Irritant · high
Irritation risk
High

Causes redness and irritation in skin. Is often added to lip roducts to create a temporary plumping effect. Is likely to have a negative effect on skin's barrier function

More about Methyl nicotinate
Propylene carbonate~0.15–0.7%
Formula
Irritation risk
Low
Works for
Moisturizing

Is used to dissolve other ingredients and create nice product texture

More about Propylene carbonate
Sodium hyaluronate~0.15–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Palmitoyl tripeptide-1~0.15–0.65%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1
Caffeine~0.1–0.4%
Irritant · medium
Irritation risk
Medium
Works for
De-puffingAnti-oxidation

Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes

More about Caffeine
Niacin~0.1–0.4%
Under-dosedIrritant · high
Irritation risk
High
Works for
MoisturizingEvens skin toneAnti-agingAnti-blemish

A form of vitamin B3. It is similar in action to niacinamide, but is more likely to cause red flashes in skin as the side effect

More about Niacin
Ascorbyl palmitate~0.05–0.3%
Irritant · medium
Irritation risk
Medium
Works for
Anti-agingAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable and can penetrate the skin better than L-Ascorbic acid. It is effective in protecting the skin from free radicals, as well as evening the skin tone, but is less effective in stimulating collagen production compared to L-Ascorbic acid.

More about Ascorbyl palmitate
Citric acid~0.05–0.25%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Cocos nucifera oil, Beeswax, Simmondsia chinensis seed oil, Ricinus communis seed oil, Helianthus annuus seed oil, Polyethylene, Polyhydroxystearic acid, Acrylates copolymer, Ethylhexyl palmitate, Vanillin, Argania spinosa kernel oil, Astrocaryum murumuru seed butter, Butyrospermum parkii butter, Oryza sativa bran extract, 1,2-hexanediol, Caprylyl glycol, Phosphatidylcholine, Tocopherol, Glycine soja oil, Tribehenin, Rosmarinus officinalis leaf extract, Octyldodecanol, Sorbitan isostearate, Helianthus annuus extract, Silica dimethyl silylate, Quaternium-90 bentonite, Butylene glycol, Pentylene glycol, Lactic acid, Methyl nicotinate, Propylene carbonate, Sodium hyaluronate, Palmitoyl tripeptide-1, Caffeine, Niacin, Ascorbyl palmitate, Citric acid

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Amazon USPrice as of 10/23/2026 21:17 GMT
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Perricone MDCold Plasma Plus+ Lip Therapy | PerriconeMDYOUR PRODUCTThe INKEY List CATripeptide Plumping Lip BalmDrunk ElephantLippe BalmBiossancePro-Peptide Hydrating Lip Perfector Balm with Hyaluronic Acid
Match—55%51%50%
Price$16.00$27.94+$11.94$6.68−$9.32$18.58+$2.58
Shared key ingredients—5 of 156 of 155 of 15
Key difference—Palmitoyl Tripeptide-38Linoleic AcidGlycerin
Irritancy Medium Low Medium Medium
Drying alcohol————
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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 22 studies and safety reviews.

  1. 1
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  5. 5
  6. 6
Perricone MD Cold Plasma Plus+ Lip Therapy | PerriconeMD
Perricone MDCold Plasma Plus+ Lip Therapy | PerriconeMD

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As an Amazon Associate, WIMJ earns from qualifying purchases.