NIOD Copper Amino Isolate Serum 3 1:1

NIOD Copper Amino Isolate Serum 3 1:1

Efficacy43/100IrritancyLow·75% recommend (2 reviews)

Works for

Moisturizing
Tripeptide-29, Myristoyl nonapeptide-3 + 8 more
Works well
What the product description says
“Suitable for daily use, this potent serum also helps to support the skin’s natural collagen production to promote a smooth, plump and glowing complexion.”
Source: SpaceNK US

This product contains good ingredients to attract water to the upper layer of the skin. These ingredients are called "humectants": dextran, glycerin.

When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. If the air is dry, humectants can speed up the moisture loss from the skin. This is why it is a good idea to use another product on top of this one to help "seal in" the moisture (look for ingredients like dimethicone, squalane, oils and butters).

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl tetrapeptide-2, myristoyl nonapeptide-3, trifluoroacetyl tripeptide-2, tripeptide-29

Tripeptide-29HeroEffect: High~5.3–6.5%
Myristoyl nonapeptide-3HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~2.7–3.3%
Trifluoroacetyl tripeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~2.2–2.7%
Acetyl tetrapeptide-2HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.9–2.4%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~5.5–6.8%
Sodium hyaluronate crosspolymerKey active· HumectantEffect: HighAttracts water into the upper layer of the skin~1.7–2.1%
GlycogenKey active· HumectantEffect: HighHelps attract water to the upper layer of the skin~1.1–1.4%
DextranKey active· HumectantEffect: HighHelps attract water to the most upper layer of the skin. Derived from sugar~0.6–0.95%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.8–1.15%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.25–0.5%
Anti-aging
Tripeptide-29, Myristoyl nonapeptide-3 + 2 more
May help
What the product description says
“The natural role of these peptides as found in the human body includes activation of a wide range of skin health functions, including healing, immune function, collagen synthesis, fibroblast production and anti-inflammatory responses, while pure GHK offers strong pro-collagen support.”
Source: Deciem

This product contains acetyl tetrapeptide-2, myristoyl nonapeptide-3, trifluoroacetyl tripeptide-2, tripeptide-29. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Tripeptide-29Key activeEffect: Medium~5.3–6.5%
Myristoyl nonapeptide-3Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~2.7–3.3%
Trifluoroacetyl tripeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~2.2–2.7%
Acetyl tetrapeptide-2Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.9–2.4%
Evens skin tone
No ingredient credited for this claim
Not delivered
What the product description says
“The concentrated formula helps to reduce the look of uneven skin tone and texture as well as working to minimise the appearance of pores and boost overall radiance.”
Source: SpaceNK US

Effective ingredients missing or their concentration is too low

Anti-blemish
No ingredient credited for this claim
Not delivered
What the product description says
“Helps to minimise the look of blemishes, uneven skin tone and visible pores”
Source: SpaceNK US

Effective ingredients missing or their concentration is too low.

Can it cause trouble?

Irritancy
8 flagged ingredients
Low risk
We flag 8 ingredients with irritancy potential; the product's overall irritancy is low. The table lists each ingredient's own rating.
IngredientFunctionIrritationEst. amount
Sodium hyaluronate crosspolymerAttracts water into the upper layer of the skinMedium~1.7–2.1%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.8–1.15%est.
EthoxydiglycolHelps to improve the product consistencyMedium~0.45–0.7%est.
Isoceteth-20Helps water and oil mix togetherMedium~0.35–0.65%est.
Leuconostoc/radish root ferment filtrateA preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determineMedium~0.3–0.55%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.25–0.5%est.
EthylhexylglycerinA preservativeMedium~0.2–0.35%est.
ChlorphenesinA preservativeMedium~0.1–0.2%est.
Comedogenic
Clean of flagged comedogenic ingredients
None flagged

User reviews

Would you recommend?
75%·yes

2 of 2 community members would buy it again.

75% would25% wouldn't
  • PBlovechild· May 2025Recommends

    Pricey, but very effective for the percentage of highly effective ingredients used in the formula.

What reviewers noticed
Marker shows the average response

Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~5.5–6.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Tripeptide-29~5.3–6.5%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging
More about Tripeptide-29
Copper tripeptide-1 acetate~4.2–5.2%
Formula
Tripeptide-1 acetate~3.4–4.2%
Formula
Myristoyl nonapeptide-3~2.7–3.3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Myristoyl nonapeptide-3
Trifluoroacetyl tripeptide-2~2.2–2.7%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Trifluoroacetyl tripeptide-2
Acetyl tetrapeptide-2~1.9–2.4%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl tetrapeptide-2
Sodium hyaluronate crosspolymer~1.7–2.1%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Attracts water into the upper layer of the skin

More about Sodium hyaluronate crosspolymer
Glycogen~1.1–1.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the upper layer of the skin

More about Glycogen
Propanediol~0.95–1.15%
Formula
Irritation risk
Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol
Pentylene glycol~0.8–1.15%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Dextran~0.6–0.95%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps attract water to the most upper layer of the skin. Derived from sugar

More about Dextran
Dimethyl isosorbide~0.55–0.85%
Formula
Irritation risk
Low

Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin

More about Dimethyl isosorbide
Ethoxydiglycol~0.45–0.7%
Irritant · medium
Irritation risk
Medium

Helps to improve the product consistency

More about Ethoxydiglycol
Isoceteth-20~0.35–0.65%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps water and oil mix together

More about Isoceteth-20
Leuconostoc/radish root ferment filtrate~0.3–0.55%
Irritant · medium
Irritation risk
Medium

A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine

More about Leuconostoc/radish root ferment filtrate
Caprylyl glycol~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Ethylhexylglycerin~0.2–0.35%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Phenoxyethanol~0.1–0.2%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Chlorphenesin~0.1–0.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about Chlorphenesin
Ingredient list view

Water, Glycerin, Tripeptide-29, Copper tripeptide-1 acetate, Tripeptide-1 acetate, Myristoyl nonapeptide-3, Trifluoroacetyl tripeptide-2, Acetyl tetrapeptide-2, Sodium hyaluronate crosspolymer, Glycogen, Propanediol, Pentylene glycol, Dextran, Dimethyl isosorbide, Ethoxydiglycol, Isoceteth-20, Leuconostoc/radish root ferment filtrate, Caprylyl glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
NIODCopper Amino Isolate Serum 3 1:1YOUR PRODUCTMaskadAnti aging serumCoreana LabAmple:N Peptide Shot AmpouleDanne Montague-KingDMK Super Serum
Match—44%44%38%
Price$58.00—$18.32−$39.68$121.68+$63.68
Shared key ingredients—4 of 84 of 83 of 8
Key difference—Copper Tripeptide-1Copper Tripeptide-13-O-Ethyl Ascorbic Acid
Irritancy Low Low Low Low
Drying alcohol————
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Product summary

"NIOD - Copper Amino Isolate Serum 3 1: 1" is effective for: Moisturizing

This product could be helpful for: Anti-aging, but its actives are not the most effective or are not well-studied.

Ingredient callouts

  • Peptides (myristoyl nonapeptide-3 2.40% - 3.00%, acetyl tetrapeptide-2 1.50% - 1.90%, tripeptide-29 5.10% - 6.20%, trifluoroacetyl tripeptide-2 1.90% - 2.30% and tripeptide-1 3.90% (declared)). There are many different kind of Peptides and they are naturally present in our skin. They all are a combination of aminoacids. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The science is still not settled on how effective Peptides are in skincare, but it is very likely that they have a benefit. They might help restore the skin barrier and fight the signs of aging. At the very least, Peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.
  • Humectants (glycogen 1.00% - 1.30%, glycerin 5.50% - 6.70%, dextran 0.55% - 0.85% and sodium hyaluronate crosspolymer 1.30% - 1.60%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.

What our users say

Based on 1 review 50% recommend this product
  • When it comes to comedogenicity, the reviewer found that it does not clog pores.
  • When it comes to using this sunscreen under makeup, the user found that it pills under a foundation.
In terms of the smell, our users report that light fragrance.

Price

The product retails from 90.00$ up to 104.00$ in the United States, from 38.00£ up to 59.99£ in the United Kingdom, for 66.50CA$ in Canada and for 58.50A$ in Australia.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 3 studies and safety reviews.

  1. 1
  2. 2
  3. 3
NIOD Copper Amino Isolate Serum 3 1:1
NIODCopper Amino Isolate Serum 3 1:1

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