Works for:
based on ingredients and %- Moisturizing
- Anti-aging
- Anti-oxidation
Doesn't work for:
based on ingredients and %- Evens skin tone
Can it cause trouble?
- Irritation risk: medium
- Comedogenic risk ingredients: 2
Key actives
Product Summary
"ISNTREE - CICA Relief Cream" is a well-rounded moisturizing product. To work well, any moisturizer needs to include a combination of water-binding and emollient ingredients. ISNTREE - CICA Relief Cream ticks this box. Acetyl hexapeptide-8, glycerin, leontopodium alpinum callus culture extract, butylene glycol and dextrin in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (palmitoyl tripeptide-1, beeswax, caprylic/capric triglyceride, cetearyl alcohol and coco-caprylate/caprate) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- This moisturizer also contains Peptides (acetyl hexapeptide-8 0.25% - 0.45%, sh-oligopeptide-1 0.25% - 0.45%, palmitoyl tripeptide-1 0.30% - 0.55% and copper tripeptide-1 0.25% - 0.45%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that they are helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
- Adenosine 0.25% - 0.40%. It is a chemical present inside our skin cells. A clinical trial confirmed that topical application of Adenosine in a low concentration can reduce dynamic wrinkles (these are the wrinkles that appear with age in a places where our mimic is the most active, for example, in the corners of the eyes or on the forehead).
- Actives derived from an extract of the Centella Asiatica plant (also known as Gotu Kola) - asiaticoside 0.25% - 0.40% The Centella Asiatica Actives, even in low concentration, can help reduce inflammation in skin, strengthen the skin barrier and reduce photodamage. They can also help to decrease scarring.
Irritation risk
There are actives in this product that can be irritating. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
About the brand
According to Cruelty-Free Kitty "ISNTREE" is cruelty free and so is its parent company.
Price
The product retails for 26.50A$ in Australia and for 26.48$ in the United States.
For a detailed price comparison: click here.
Anti-aging
What does the product description say?
Formulated with 100,000ppm Centella Asiatica Extract and Asiaticoside to protect and hydrate skin Improves skin elasticity and strengthens skin barrier Adenosine reduces appearances of fine lines and wrinkles
Source: Lila Beauty
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, asiaticoside, centella asiatica extract, copper tripeptide-1, palmitoyl tripeptide-1, sh-oligopeptide-1.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Anti-oxidation
This product contains antioxidants (asiaticoside) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).
The following ingredients - centella asiatica extract also can have an antioxidant effect, but there is less evidence to confirm their effectiveness in skin.
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A plant extract that might have some anti-oxidant effect helping neutralize free radicals in skin
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
A plant stem cell extract that might help neutralize free radicals and reduce inflammation in skin
A plant extract that is rich in a fragrance compound eugenol that is a frequent allergen and can be irritating. It might also contain anti-oxidants to help neutralize free radicals
A plant extract that might be helpful to neutralize free radicals in skin
Eggplant fruit extract. Might have some anti-oxidant effect
Moisturizing
What does the product description say?
CICA Relief Cream
Source: From product name
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
glycerin, leontopodium alpinum callus culture extract.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: beeswax, caprylic/capric triglyceride.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-8, copper tripeptide-1, palmitoyl tripeptide-1, sh-oligopeptide-1
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Helps to soften the upper layer of the skin without creating a greasy texture
A plant stem cell extract that might help neutralize free radicals and reduce inflammation in skin
A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin
An emollient that can also help water and oil mix together, as well as prevent bacteria growth in products
An emollient that is naturally present in skin and helps soften it
A plant oil that helps soften the upper layer of the skin. Is unlikely to be helpful in restoring skin barrier function due to the low content of linoleic acid
Helps to soften the upper layer of the skin and create a nice product texture
Helps soften the upper layer of the skin and improve the product's texture
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
Evens skin tone
What does the product description say?
EGF and Peptide also make it a wonderful anti-aging moisturiser, helping to firm skin and evening out skin tone. 50 ml / 1.76 fl oz
Source: beauty and Seoul
Effective ingredients missing or their concentration is too low
How honest is this product?
| Promise | Can it deliver? |
|---|---|
| Anti-aging | |
| Moisturizing | |
| Evens skin tone |
Total Promises Fulfilled score: 66/100.
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Potential irritants
Comedogenic ingredients
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| Product | Similarity | Price | Irritancy |
|---|---|---|---|
 ISNTREE CICA Relief Cream | Current | $26.48 | |
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 The Beauty Crop PEPTIDE CALM MOISTURISING BARRIER BALM | 53% | $24.00 | |
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Key Actives
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
A plant extract that has anti-bacterial properties. Can be used to preserve the product. Can be irritating
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen
Potential irritants
A plant extract that has anti-bacterial properties. Can be used to preserve the product. Can be irritating
A plant extract that can contain an active compound curcumin, that may have some anti-inflammatory properties when applied to the skin, but solid research is lacking and the typical concentration used in skincare products is too low. Can be an irritant
A plant extract that is rich in a fragrance compound eugenol that is a frequent allergen and can be irritating. It might also contain anti-oxidants to help neutralize free radicals
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
A plant extract that might be helpful to neutralize free radicals in skin
A plant extract that might have some anti-oxidant effect helping neutralize free radicals in skin
Eggplant fruit extract. Might have some anti-oxidant effect
A plant oil that helps soften the upper layer of the skin. Is unlikely to be helpful in restoring skin barrier function due to the low content of linoleic acid
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
Helps water and oil in the product mix well together and improves product texture
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
Helps soften the upper layer of the skin and improve the product's texture
Comedogenic ingredients
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
All ingredients
A plant extract that has been shown to be able to reduce inflammation in skin, support restoration of skin barrier function, as well as support collagen production. Contains active compounds called centelloids: asiaticoside, madecasosside, asiatic acid and madecassic acid. Might be helpful in preventing stretch marks. It can be itself be irritating though.
Helps to dissolve other ingredients in a formulation. Slows down the rate of product drying
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
Helps to soften the upper layer of the skin and create a nice product texture
A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture
Forms a protective barrier that holds water and keeps dry skin hydrated. Keeps an emulsion from separating into its oil and liquid components, and increases the thickness of a product. Can be an allergen
Helps to soften the upper layer of the skin without creating a greasy texture
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
A plant stem cell extract that might help neutralize free radicals and reduce inflammation in skin
A plant extract that has anti-bacterial properties. Can be used to preserve the product. Can be irritating
A plant extract that might be helpful to neutralize free radicals in skin
A plant extract that might have some anti-oxidant effect helping neutralize free radicals in skin
Eggplant fruit extract. Might have some anti-oxidant effect
A plant extract that can contain an active compound curcumin, that may have some anti-inflammatory properties when applied to the skin, but solid research is lacking and the typical concentration used in skincare products is too low. Can be an irritant
A plant extract that is rich in a fragrance compound eugenol that is a frequent allergen and can be irritating. It might also contain anti-oxidants to help neutralize free radicals
Red algae extract that helps attract water to the upper layer of the skin and might contain antioxidants
Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.
An emollient that can also help water and oil mix together, as well as prevent bacteria growth in products
A plant oil that helps soften the upper layer of the skin. Is unlikely to be helpful in restoring skin barrier function due to the low content of linoleic acid
An active compound of Centella Asiatica plant extract. In combination with other active compounds of Centella Asiatica extract (madecasosside, asiatic acid and madecassic acid), asiaticoside has been shown to be helpful in wound-healing, restoring skin barrier function and supporting collagen production in skin. It can, however, itself be irritating
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.
Helps attract water to the upper layer of the skin and can help improve skin barrier function
Helps calm down inflammation in skin and can help reduce itching. Helps to repair the skin barrier and keep skin hydrated
An emollient that is naturally present in skin and helps soften it
Helps water and oil in the product mix well together and improves product texture
A gelling agent that thickens the product consistency and leaves the skin with a velvety finish
Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)
Helps soften the upper layer of the skin and improve the product's texture
Used to create thicker product consistency and stabilize emulsions
A sugar that is used to stabilize the product formulation. Can help attract water to the upper layer of the skin
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
Ingredient list view
Water, Centella asiatica extract, Dipropylene glycol, Caprylic/capric triglyceride, Glycerin, Hydrogenated polydecene, Cetearyl alcohol, Beeswax, Coco-caprylate/caprate, 1,2-hexanediol, Cetearyl olivate, Glyceryl stearate, Leontopodium alpinum callus culture extract, Melia azadirachta leaf extract, Melia azadirachta flower extract, Coccinia indica fruit extract, Amber powder, Solanum melongena fruit extract, Curcuma longa root extract, Ocimum sanctum leaf extract, Corallina officinalis extract, Hydrogenated lecithin, Glyceryl caprylate, Moringa oleifera seed oil, Asiaticoside, Sh-oligopeptide-1, Acetyl hexapeptide-8, Palmitoyl tripeptide-1, Copper tripeptide-1, Phosphatidylcholine, Panthenol, Allantoin, Palmitic acid, Cetearyl glucoside, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Adenosine, Xanthan gum, C12-16 alcohols, Microcrystalline cellulose, Cellulose gum, Dextrin, Sorbitan olivate, Butylene glycol, Ethylhexylglycerin
- Anti-Inflammatory Effect of Titrated Extract of Centella asiatica in Phthalic Anhydride-Induced Allergic Dermatitis Animal Model
- Centella asiatica in cosmetology
- Triterpene Composition and Bioactivities of Centella asiatica
- Asiaticoside induction for cell-cycle progression, proliferation and collagen synthesis in human dermal fibroblasts
- Assessment report on Centella asiatica (L.) Urban, herba
- Contact dermatitis due to Madecassol
- The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial
- Glycerol and the skin: holistic approach to its origin and functions
- Safety Assessment of Polyene Group as Used in Cosmetics
- Safety Assessment of Alkyl Esters as Used in Cosmetics
- The influence of alkane chain length on the skin irritation potential of 1,2-alkanediols
- Anti-Inflammatory Effects of Concentrated Ethanol Extracts of Edelweiss (Leontopodium alpinum Cass.) Callus Cultures towards Human Keratinocytes and Endothelial Cells
- Melia azedarach
- Preliminary and Pharmacological Profile of Melia azedarach L.: An Overview
- In Vitro antioxidative and anti-inflammatory activities of the ethanol extract of eggplant (Solanum melongena) stalks in macrophage RAW 264.7 cells
- Vaughn, A. R., Branum, A., & Sivamani, R. K. (2016). Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence. Phytotherapy Research, 30(8), 1243–1264. doi:10.1002/ptr.5640
- Moringa oleifera seed oil: Composition, nutritional aspects and health attributes
- Moringa oleifera Seeds and Oil: Characteristics and Uses for Human Health
- Contact dermatitis due to Madecassol
- Centella asiatica in Dermatology: An Overview
- Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data
- Topical Peptide Treatments with Effective Anti-Aging Results
- Effects of topical creams containing vitamin C, a copper-binding peptide cream and melatonin compared with tretinoin on the ultrastructure of normal skin - A pilot clinical, histologic, and ultrastructural study
- Selected Biomarkers Revealed Potential Skin Toxicity Caused by Certain Copper Compounds
- Skin moisturizing effects of panthenol-based formulations
- Safety Assessment of Panthenol, Pantothenic Acid, and Derivatives as Used in Cosmetics
- Profile of wound healing process induced by allantoin
- Evaluation of anti-wrinkle efficacy of adenosine-containing products using the FOITS technique