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ISANA Pro-Collagen Night Cream
ISANA

ISANA Pro-Collagen Night Cream

Efficacy37/100IrritancyHigh
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Works for

1 of 2 advertised claims delivered

Moisturizing
Sodium hyaluronate, Caprylic/capric triglyceride + 12 more
Good evidence
What the product description says
“Pro-Collagen Night Cream”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, sodium hyaluronate.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: caprylic/capric triglyceride, helianthus annuus seed oil.

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~0.35–0.85%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~2.8–4.2%
Collagen amino acidsKey activeEffect: HighHelp attract water to the upper layer of the skin, soften it and support the skin barrier function~0.35–0.75%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.1–6.2%
Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.3–0.7%
Simmondsia chinensis seed oilKey active· Emollient, OcclusiveEffect: HighSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.~1.1–1.7%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~3.1–4.6%
Ethylhexyl stearate· EmollientEffect: LowHelps soften the upper layer of the skin~2.1–3.1%
Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.1–0.35%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.05–0.25%
Glyceryl stearate citrate· EmollientEffect: LowHelps oil and water mix together while softening the upper layer of the skin~1.4–2.2%
Dicaprylyl carbonate· EmollientEffect: LowHelps products spread more easily and works as an emollient to soften skin~1.7–2.6%
Butyrospermum parkii butterUnder-dosedEffect: HighA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.9–1.3%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.7%
Anti-aging
Butyrospermum parkii butter, Tocopherol
Weak evidence
What the product description says
“This night cream is designed to boost your skin’s collagen synthesis and restore its elasticity.”
Source: German Drugstore

Effective ingredients missing or their concentration is too low.

Butyrospermum parkii butterEffect: Low, below effective doseA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.9–1.3%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.3–0.7%

Can it cause trouble?

Irritancy
5 strong irritants: Phenol, Parfum + 3 more — patch-test recommended
High risk
We flagged 12 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
PhenolA harsh exfoliant and preservative. It is banned from using in cosmetics in the EUHigh~0.55–1.25%est.
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.1–0.45%est.
Alpha-isomethyl iononeA fragrance. Potential allergen and can be irritatingHigh~0.1–0.45%est.
LinaloolA fragrance. Can be irritatingHigh~0.1–0.35%est.
Hexyl cinnamalA fragrance with jasmine smell. A likely irritantHigh~0.1–0.3%est.
Benzyl alcoholA preservative. Can be used to mask unpleasant smell. Can be irritatingHigh~0.05–0.25%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~2.8–4.2%est.
Simmondsia chinensis seed oilSoftens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.Medium~1.1–1.7%est.
Leuconostoc/radish root ferment filtrateA preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determineMedium~0.2–0.8%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.15–0.6%est.
Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.1–0.35%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.05–0.25%est.
Comedogenic
2 ingredients rated 2 or more on the 0–5 pore-clogging scale
2 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.9–1.3%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~3.1–4.6%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Glycerin~4.1–6.2%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Cetearyl alcohol~3.1–4.6%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Caprylic/capric triglyceride~2.8–4.2%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Ethylhexyl stearate~2.1–3.1%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Ethylhexyl stearate
Dicaprylyl carbonate~1.7–2.6%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps products spread more easily and works as an emollient to soften skin

More about Dicaprylyl carbonate
Glyceryl stearate citrate~1.4–2.2%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together while softening the upper layer of the skin

More about Glyceryl stearate citrate
Potassium phosphate~1.3–1.9%
Formula
Irritation risk
Low

Helps regulate the pH of the formulation

More about Potassium phosphate
Simmondsia chinensis seed oil~1.1–1.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.

More about Simmondsia chinensis seed oil
Butyrospermum parkii butter~0.9–1.3%
Under-dosedComedogenic 3/5
Irritation risk
Low
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter
Phenol~0.55–1.25%
Irritant · high
Irritation risk
High
Works for
Exfoliation

A harsh exfoliant and preservative. It is banned from using in cosmetics in the EU

More about Phenol
Bulbine frutescens leaf juice~0.4–0.95%
Formula
Irritation risk
Low
More about Bulbine frutescens leaf juice
Sodium hyaluronate~0.35–0.85%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate
Collagen amino acids~0.35–0.75%
Key active
Irritation risk
Low
Works for
Moisturizing

Help attract water to the upper layer of the skin, soften it and support the skin barrier function

More about Collagen amino acids
Tocopherol~0.3–0.7%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-inflammatoryAnti-agingMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Leuconostoc/radish root ferment filtrate~0.2–0.8%
Irritant · medium
Irritation risk
Medium

A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine

More about Leuconostoc/radish root ferment filtrate
Helianthus annuus seed oil~0.3–0.7%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Citric acid~0.15–0.6%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Parfum~0.1–0.45%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Alpha-isomethyl ionone~0.1–0.45%
Irritant · high
Irritation risk
High

A fragrance. Potential allergen and can be irritating

More about Alpha-isomethyl ionone
Linalool~0.1–0.35%
Irritant · high
Irritation risk
High

A fragrance. Can be irritating

More about Linalool
Hexyl cinnamal~0.1–0.3%
Irritant · high
Irritation risk
High

A fragrance with jasmine smell. A likely irritant

More about Hexyl cinnamal
Benzyl alcohol~0.05–0.25%
Irritant · high
Irritation risk
High

A preservative. Can be used to mask unpleasant smell. Can be irritating

More about Benzyl alcohol
Pentylene glycol~0.1–0.35%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol
Caprylyl glycol~0.05–0.25%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Phenoxyethanol~0.05–0.25%
Formula
Irritation risk
Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol
Ingredient list view

Water, Glycerin, Cetearyl alcohol, Caprylic/capric triglyceride, Ethylhexyl stearate, Dicaprylyl carbonate, Glyceryl stearate citrate, Potassium phosphate, Simmondsia chinensis seed oil, Butyrospermum parkii butter, Phenol, Bulbine frutescens leaf juice, Sodium hyaluronate, Collagen amino acids, Tocopherol, Leuconostoc/radish root ferment filtrate, Helianthus annuus seed oil, Citric acid, Parfum, Alpha-isomethyl ionone, Linalool, Hexyl cinnamal, Benzyl alcohol, Pentylene glycol, Caprylyl glycol, Phenoxyethanol

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 9 studies and safety reviews.

  1. 1
    Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
  2. 2
    Hyaluronic acid: A key molecule in skin agingncbi.nlm.nih.gov
  3. 3
    Hyaluronan (Hyaluronic Acid): a natural moisturizer for skin careresearchgate.net
  4. 4
    Vitamin E in dermatologyncbi.nlm.nih.gov
  5. 5
    Vitamin E and Skin Healthlpi.oregonstate.edu
  6. 6
    Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Careonlinelibrary.wiley.com
ISANA Pro-Collagen Night Cream
ISANAPro-Collagen Night Cream
Buy at German DrugstoreCheck priceAmazon

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Buy at German DrugstoreCheck priceAmazon

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