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Product summary

Based on the ingredients included, "Goldfaden MD - Wake Up Call Overnight Regenerative Facial Treatment" works well for moisturizing the skin. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Humectants in this product (acetyl hexapeptide-8, glycerin, saccharomyces/copper ferment and sodium hyaluronate) help to increase the water content in the upper layer of the skin. (These ingredients do so by "capturing" water molecules from the outside air or from within the deeper layers of the skin). Glycine soja oil, persea gratissima oil, vitis vinifera seed oil, caprylic/capric triglyceride and squalane in this product help decrease the water evoporation from the skin, so that it stays hydrated for longer. These ingredients also soften the skin and take away the feeling of tightness and dryness.

Ingredient callouts

  • this moisturizer includes a form of retinoids (vitamin A) - retinyl palmitate 0.25% - 0.40%, but this type of vitamin A is not very effective. It could in theory help with fine lines and wrinkles, but the effect is most likely minimal.
  • We like that this moisturizer contains peptides (acetyl hexapeptide-8 0.55% - 0.85%). There are many different kind of peptides and they are naturally present in our skin. They all are a combination of amino-acids. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The science is still not settled on how effective peptides in skincare are, but it is very likely that they have a benefit. Peptides might help restore the skin barrier and fight the signs of aging. At the very least, peptides work as humectants: they attract water to the upper layer of the skin and improve its hydration.

Irritation risk

This formulation includes some common irritants, including ingredients that do not provide a benefit for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.


The product retails from 75.00$ up to 85.00$ in the United States, from 11.99£ up to 80.00£ in the United Kingdom and for 102.00CA$ in Canada.

For a detailed price comparison: click here.