GlyMed Plus

GlyMed Plus Peptide Serum

Name: GlyMed Plus - Peptide Serum
Brand: GlyMed Plus

Efficacy87/100IrritancyHigh·

See all ingredients

Works for

Moisturizing

Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 + 15 more

Works well

What the product description says

“Activate the skin's self-defense system with this barrier repair formulation.”

Source: GlyMed Plus

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: glycerin, glycine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: palmitoyl tetrapeptide-7, palmitoyl tripeptide-1.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl sh-heptapeptide-1, copper tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, panthenol

Palmitoyl tripeptide-1Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.6–2.4%

Palmitoyl tetrapeptide-7Hero· EmollientEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.4–2%

Acetyl sh-heptapeptide-1HeroEffect: HighA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.2–1.7%

Copper tripeptide-1HeroEffect: HighA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.95–1.4%

PanthenolHero· HumectantEffect: HighHelps attract water to the upper layer of the skin and can help improve skin barrier function~0.6–1.35%

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.3–6.5%

Sodium hyaluronateKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Attracts water into the upper layer of the skin~1.9–2.9%

GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.2–0.75%

Hydrolyzed soy proteinKey active· HumectantEffect: MediumHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.75%

Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~3.6–5.4%

Sorbitol· HumectantEffect: LowHelps attract water to the upper layer of the skin and improves the product texture~0.4–0.9%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~0.35–0.8%

Moringa oleifera seed oil· EmollientEffect: LowA plant oil that helps soften the upper layer of the skin. Is unlikely to be helpful in restoring skin barrier function due to the low content of linoleic acid~0.1–0.5%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.1–0.3%

Camellia sinensis leaf extractEffect: LowCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.1–0.5%

LecithinEffect: Low, below effective doseUsed mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin~0.1–0.5%

Butyrospermum parkii butterUnder-dosedA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.15–0.55%

Anti-aging

Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 + 5 more

May help

What the product description says

“This peptide serum reduces DNA oxidation, neutralizes free radicals and increases antioxidants to fight against environmental and chronological aging.”

Source: GlyMed Plus

This product contains acetyl sh-heptapeptide-1, copper tripeptide-1, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1. These ingredients might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

Palmitoyl tripeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.6–2.4%

Palmitoyl tetrapeptide-7Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.4–2%

Acetyl sh-heptapeptide-1Key activeEffect: MediumA type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles~1.2–1.7%

Copper tripeptide-1Key activeEffect: MediumA naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.~0.95–1.4%

Butyrospermum parkii butterEffect: Low, below effective doseA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals~0.15–0.55%

Tetrahexyldecyl ascorbateUnder-dosedBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.~0.1–0.4%

Anti-oxidation

Side benefit · Camellia sinensis leaf extract, Hydrolyzed soy protein + 3 more

May help

This product contains antioxidants (camellia sinensis leaf extract) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.

Camellia sinensis leaf extractKey activeEffect: MediumCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.1–0.5%

Hydrolyzed soy proteinEffect: LowHelps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing~0.2–0.75%

Rosmarinus officinalis leaf extractEffect: Low, below effective doseCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating~0.1–0.45%

Can it cause trouble?

Irritancy

3 strong irritants: Rosa centifolia flower water, Rosmarinus officinalis leaf extract + 1 more — patch-test recommended

High risk

We flagged 10 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Phenethyl alcoholA fragrance. Can be irritatingHigh~0.15–0.7%est.

Rosa centifolia flower water—High~0.15–0.55%est.

Rosmarinus officinalis leaf extractCan be helpful in reducing inflammation in skin, including inflamed acne. It can be irritatingHigh~0.1–0.45%est.

Rosa centifolia flower oilAn essential oil. Can be irritatingHigh~0.1–0.4%est.

Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~3.6–5.4%est.

Moringa oleifera seed oilA plant oil that helps soften the upper layer of the skin. Is unlikely to be helpful in restoring skin barrier function due to the low content of linoleic acidMedium~0.1–0.5%est.

Tetrahexyldecyl ascorbateBeing a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.Medium~0.1–0.4%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.1–0.3%est.

Hexylene glycolHelps create a more spreadable product textureMedium~0.05–0.2%est.

EthylhexylglycerinA preservativeMedium~0.01–0.05%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Butyrospermum parkii butterA great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals3/5~0.15–0.55%est.

Alternatives

Cheaper, or higher on efficacy

Arencia Deep Water Surge Serum

Higher efficacy · 100/10061% match

$32.63

Korean Triple Pure Hyaluronic Acid Serum for Face + 2% Niacinamide B3 + Vitamin B5 + 8 Peptides for Deep Firming, Plump Wrinkles, Hydrating Dewy Skin, Anti Aging Acido Hialuronico Facial Serum

Matkas Korean Triple Pure Hyaluronic Acid Serum for Face + 2% Niacinamide B3 + Vitamin B5 + 8 Peptides for Deep Firming, Plump Wrinkles, Hydrating Dewy Skin, Anti Aging Acido Hialuronico Facial Serum

Higher efficacy · 100/10058% match

$25.97

View all alternatives

User reviews

Would you recommend?

100%·yes

1 of 1 community members would buy it again.

100% would0% wouldn't

skinticians· Aug 2022Recommends
helps against DNA Oxidation. I love the sun and I need all the help I can get when it comes to free radical damage.
Anti-aging
Excellent
Texture
Light
Pilling under makeup
Not at all
Clogging pores
Doesn't clog pores
Smell
Light fragrance

What reviewers noticed

Marker shows the average response

Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.3–6.5%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Pentylene glycol~3.6–5.4%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol

Polysorbate 20~2.4–3.6%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 20

Sodium hyaluronate~1.9–2.9%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Attracts water into the upper layer of the skin

More about Sodium hyaluronate

Palmitoyl tripeptide-1~1.6–2.4%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tripeptide-1

Palmitoyl tetrapeptide-7~1.4–2%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Palmitoyl tetrapeptide-7

Acetyl sh-heptapeptide-1~1.2–1.7%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles

More about Acetyl sh-heptapeptide-1

Copper tripeptide-1~0.95–1.4%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingAnti-aging

A naturally occurring peptide. One of the most studied peptides in dermatology. It is sometimes abbreviated GHK-Cu. Belongs to the class of carrier peptides. It stimulates both synthesis and breakdown of collagen in skin. It is released in skin wounds and inflammation to support healing. It accelerates wound-healing of the skin and can stimulate hair growth. There are preliminary studies that confirm that copper tripeptide can help support collagen production reducing fine lines and wrinkles and decrease inflammation in skin.

More about Copper tripeptide-1

Panthenol~0.6–1.35%

Hero · Moisturizing

Irritation risk: Low

Works for

MoisturizingReduces rednessReduces irritation

Helps attract water to the upper layer of the skin and can help improve skin barrier function

More about Panthenol

Glycereth-26~0.45–1.05%

Formula

Irritation risk: Low

Helps create a thicker product consistency

More about Glycereth-26

Sorbitol~0.4–0.9%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps attract water to the upper layer of the skin and improves the product texture

More about Sorbitol

Butylene glycol~0.35–0.8%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Dimethyl mea~0.3–0.75%

Formula

Irritation risk: Low

More about Dimethyl mea

Glycine~0.2–0.75%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine

Hydrolyzed soy protein~0.2–0.75%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidationAnti-inflammatoryEvens skin tone

Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing

More about Hydrolyzed soy protein

Hydrogenated lecithin~0.2–0.75%

Formula

Irritation risk: Low

Works for

Cleansing

Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.

More about Hydrogenated lecithin

Phenethyl alcohol~0.15–0.7%

Irritant · high

Irritation risk: High

A fragrance. Can be irritating

More about Phenethyl alcohol

Propanediol~0.15–0.65%

Formula

Irritation risk: Low

Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin

More about Propanediol

Rosa centifolia flower water~0.15–0.55%

Irritant · high

Irritation risk: High

More about Rosa centifolia flower water

Malus domestica fruit cell culture extract~0.1–0.5%

Formula

Irritation risk: Low

More about Malus domestica fruit cell culture extract

Rosmarinus officinalis leaf extract~0.1–0.45%

Irritant · high

Irritation risk: High

Works for

Anti-blemishAnti-oxidationAntibacterial

Can be helpful in reducing inflammation in skin, including inflamed acne. It can be irritating

More about Rosmarinus officinalis leaf extract

Camellia sinensis leaf extract~0.1–0.5%

Key active

Irritation risk: Low

Works for

Anti-oxidationAntibacterialAnti-agingAnti-blemishEvens skin toneMoisturizing

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract

Hibiscus abelmoschus extract~0.1–0.45%

Formula

Irritation risk: Low

More about Hibiscus abelmoschus extract

Butyrospermum parkii butter~0.15–0.55%

Under-dosedComedogenic 3/5

Irritation risk: Low
Comedogenicity: 3/5

Works for

MoisturizingAnti-oxidationAnti-aging

A great moisturising ingredient that softens the skin and reduces water loss from its upper layer. It also can be helpful in protecting skin from free radicals

More about Butyrospermum parkii butter

Rosa centifolia flower oil~0.1–0.4%

Irritant · high

Irritation risk: High

An essential oil. Can be irritating

More about Rosa centifolia flower oil

Moringa oleifera seed oil~0.1–0.5%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

A plant oil that helps soften the upper layer of the skin. Is unlikely to be helpful in restoring skin barrier function due to the low content of linoleic acid

More about Moringa oleifera seed oil

Tetrahexyldecyl ascorbate~0.1–0.4%

Under-dosedIrritant · medium

Irritation risk: Medium

Works for

Anti-agingEvens skin toneAnti-oxidation

Being a lipid soluble form of vitamin C, it is more stable than ascorbic acid, but still degrades quickly and needs to be stabilized in a formulation with another ingredient. It is claimed to penetrate skin better than pure vitamin C and have the the similar benefits, but solid studies of its effectiveness are lacking. Is likely to require a higher concentration in a product than pure vitamin C to be effective. It might be able to help reduce pore clogging.

More about Tetrahexyldecyl ascorbate

Lecithin~0.1–0.5%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin

More about Lecithin

Xanthan gum~0.1–0.35%

Formula

Irritation risk: Low

Works for

Cleansing

Used to create a thicker product consistency

More about Xanthan gum

Carbomer~0.05–0.25%

Formula

Irritation risk: Low

Works for

Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer

Caprylyl glycol~0.1–0.3%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Hexylene glycol~0.05–0.2%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps create a more spreadable product texture

More about Hexylene glycol

Phenoxyethanol~0.05–0.15%

Formula

Irritation risk: Low

A preservative. It helps prevent bacterial growth in cosmetic products

More about Phenoxyethanol

Ethylhexylglycerin~0.01–0.05%

Irritant · medium

Irritation risk: Medium

A preservative

More about Ethylhexylglycerin

Sodium hydroxide~0.01–0.05%

Formula

Irritation risk: Low

Used to adjust the product's pH

More about Sodium hydroxide

Ingredient list view

Water, Glycerin, Pentylene glycol, Polysorbate 20, Sodium hyaluronate, Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7, Acetyl sh-heptapeptide-1, Copper tripeptide-1, Panthenol, Glycereth-26, Sorbitol, Butylene glycol, Dimethyl mea, Glycine, Hydrolyzed soy protein, Hydrogenated lecithin, Phenethyl alcohol, Propanediol, Rosa centifolia flower water, Malus domestica fruit cell culture extract, Rosmarinus officinalis leaf extract, Camellia sinensis leaf extract, Hibiscus abelmoschus extract, Butyrospermum parkii butter, Rosa centifolia flower oil, Moringa oleifera seed oil, Tetrahexyldecyl ascorbate, Lecithin, Xanthan gum, Carbomer, Caprylyl glycol, Hexylene glycol, Phenoxyethanol, Ethylhexylglycerin, Sodium hydroxide

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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
	GlyMed PlusPeptide SerumYOUR PRODUCT	ArenciaDeep Water Surge Serum	MatkasKorean Triple Pure Hyaluronic Acid Serum for Face + 2% Niacinamide B3 + Vitamin B5 + 8 Peptides for Deep Firming, Plump Wrinkles, Hydrating Dewy Skin, Anti Aging Acido Hialuronico Facial Serum	NEOGEN X SUR.MEDICAGECURE ONE MINUTE WRINKLE PERFECTION
Match	—	61%	58%	57%
Price	—	$32.63	$25.97	—
Shared key ingredients	—	7 of 10	6 of 10	8 of 10
Key difference	—	Hexapeptide-9	Hexapeptide-9	Madecassoside
Irritancy	High	Medium	Medium	High
Drying alcohol	—	—	—	Contains drying alcohol
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