Dr.Different 113 Moisturizer

Dr.Different 113 Moisturizer

Efficacy100/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Moisturizing
25 ingredients credited for this claim
Strong support
What the product description says
“113 Moisturizer”
From product name

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: alanine, arginine.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: arginine, caprylic/capric triglyceride.

The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: ceramide np, phytosphingosine

GlycosphingolipidsKey active· EmollientEffect: HighA type of lipids naturally present in skin. They can be converted to ceramides in skin~0.15–0.3%
Hydroxypropyl bispalmitamide meaKey active· EmollientEffect: High~0.5–0.75%
PhytosphingosineHero· EmollientEffect: HighA type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect~0.15–0.3%
Sodium pcaKey active· HumectantEffect: HighNaturally present in skin and helps to attract water to its upper layer~0.25–0.45%
Caprylic/capric triglycerideKey active· Emollient, OcclusiveEffect: HighA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin~5.5–6.7%
SerineKey activeEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.45%
Ceramide npHero· EmollientEffect: HighA type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin~0.25–0.45%
AlanineKey active· HumectantEffect: HighAn amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking~0.15–0.3%
CholesterolKey active· EmollientEffect: HighAn emollient that is naturally found in skin~0.75–1.1%
Glutamic acidKey active· HumectantEffect: HighAn amino-acid that helps attract water to the upper layer of the skin~0.15–0.3%
GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~3.1–3.8%
ArginineKey active· Humectant, OcclusiveEffect: HighAn amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin~0.3–0.55%
GlycineKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin and can help restore the skin barrier function~0.25–0.4%
AdenosineKey activeEffect: MediumMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.45%
Cetyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together~1.5–1.8%
Glyceryl stearate seKey activeEffect: MediumUsed to stabilize the product formulations and works as an emollient~1.7–2.1%
Olea europaea fruit oilKey active· EmollientEffect: MediumAn emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation~0.55–0.8%
Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.3–0.55%
Oleic acid· EmollientEffect: LowHelps soften the upper layer of the skin. At the same time, it can weaken the skin's barrier enhancing penetration of other ingredients and increasing the risk of skin dryness~0.3–0.55%
Palmitic acid· EmollientEffect: LowAn emollient that is naturally present in skin and helps soften it~0.3–0.55%
Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~4.3–5.2%
Myristyl alcohol· EmollientEffect: LowHelps to stabilize the product formulation while softening the upper layer of the skin. Can be irritating~0.35–0.65%
Linoleic acidUnder-dosedEffect: HighAn excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores~0.4–0.6%
Stearic acidEffect: Low, below effective doseHelps oil and water mix together and works as an emollient~0.55–0.85%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.5%
Anti-aging
Not advertised by the brand · 3 ingredients credited for this claim
Strong support

This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains adenosine.

These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: serine.

Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.

AdenosineKey activeEffect: HighMight help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)~0.25–0.45%
SerineKey activeEffect: MediumAn amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles~0.25–0.45%
TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.25–0.5%

Can it cause trouble?

Irritancy
1 strong irritant: Sorbitan sesquioleate
Medium risk
We flagged 11 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
Sorbitan sesquioleateUsed to help oil and water mix together. Can be irritatingHigh~0.6–0.9%est.
Myristyl alcoholHelps to stabilize the product formulation while softening the upper layer of the skin. Can be irritatingHigh~0.35–0.65%est.
Caprylic/capric triglycerideA good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerinMedium~5.5–6.7%est.
Pentaerythrityl tetraisostearateUsed to create a thicker product consistencyMedium~2.4–3%est.
1,2-hexanediolA preservativeMedium~0.95–1.2%est.
Olea europaea fruit oilAn emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammationMedium~0.55–0.8%est.
EthylhexylglycerinA preservativeMedium~0.35–0.65%est.
Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.3–0.55%est.
Oleic acidHelps soften the upper layer of the skin. At the same time, it can weaken the skin's barrier enhancing penetration of other ingredients and increasing the risk of skin drynessMedium~0.3–0.55%est.
Hydrogenated phosphatidylcholineHelps oil and water mix togetherMedium~0.25–0.5%est.
Rosa canina fruit extractA plant extract that might have some anti-oxidant properties, but evidence is lackingMedium~0.2–0.4%est.
Comedogenic
1 ingredient rated 2 or more on the 0–5 pore-clogging scale
1 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Glyceryl stearate seUsed to stabilize the product formulations and works as an emollient2/5~1.7–2.1%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~45–55%
Formula
Irritation risk
Low

Plain old water

More about Water
Caprylic/capric triglyceride~5.5–6.7%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin

More about Caprylic/capric triglyceride
Butylene glycol~4.3–5.2%
Formula
Irritation risk
Low
Works for
Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol
Glycerin~3.1–3.8%
Key active
Irritation risk
Low
Works for
Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin
Pentaerythrityl tetraisostearate~2.4–3%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Used to create a thicker product consistency

More about Pentaerythrityl tetraisostearate
1,2-hexanediol~0.95–1.2%
Irritant · medium
Irritation risk
Medium

A preservative

More about 1,2-hexanediol
Glyceryl stearate se~1.7–2.1%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

Used to stabilize the product formulations and works as an emollient

More about Glyceryl stearate se
Cetyl alcohol~1.5–1.8%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together

More about Cetyl alcohol
Stearyl alcohol~1.3–1.5%
Formula
Irritation risk
Low
Works for
Cleansing

An emollient that helps soften the skin

More about Stearyl alcohol
Cetearyl olivate~0.95–1.2%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Cetearyl olivate
Cholesterol~0.75–1.1%
Key active
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally found in skin

More about Cholesterol
Sorbitan sesquioleate~0.6–0.9%
Irritant · high
Irritation risk
High
Works for
Cleansing

Used to help oil and water mix together. Can be irritating

More about Sorbitan sesquioleate
Olea europaea fruit oil~0.55–0.8%
Key activeIrritant · medium
Irritation risk
Medium
Works for
Moisturizing

An emollient that helps soften the skin but is not effective for restoring its barrier function. Might be helpful to calm down inflammation

More about Olea europaea fruit oil
Sorbitan olivate~0.5–0.75%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Sorbitan olivate
Hydroxypropyl bispalmitamide mea~0.5–0.75%
Key active
Irritation risk
Low
Works for
Moisturizing
More about Hydroxypropyl bispalmitamide mea
Stearic acid~0.55–0.85%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

Helps oil and water mix together and works as an emollient

More about Stearic acid
Carbomer~0.45–0.65%
Formula
Irritation risk
Low
Works for
Cleansing

Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations

More about Carbomer
Ethylhexylglycerin~0.35–0.65%
Irritant · medium
Irritation risk
Medium

A preservative

More about Ethylhexylglycerin
Myristyl alcohol~0.35–0.65%
Irritant · high
Irritation risk
High
Works for
Moisturizing

Helps to stabilize the product formulation while softening the upper layer of the skin. Can be irritating

More about Myristyl alcohol
Arginine~0.3–0.55%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino acid that is naturally present in skin and helps keep it hydrated. When used together with AHAs, it can reduce their irritating effect on the skin

More about Arginine
Isomerized linoleic acid~0.3–0.55%
Formula
Lauryl alcohol~0.35–0.6%
Formula
Irritation risk
Low
Works for
Cleansing
More about Lauryl alcohol
Decylene glycol~0.25–0.45%
Formula
Irritation risk
Low

Used to creat a nice product texture and support penetration of other ingredients

More about Decylene glycol
Caprylyl glycol~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol
Xanthan gum~0.25–0.5%
Formula
Irritation risk
Low
Works for
Cleansing

Used to create a thicker product consistency

More about Xanthan gum
Adenosine~0.25–0.45%
Key active
Irritation risk
Low
Works for
Anti-agingMoisturizingAnti-oxidation

Might help improve cell turnover and reduce inflammation in skin. One study shows that the ingredients might be able to help reduce dynamic wrinkles (for example, in the corners of the eyes or on the forehead)

More about Adenosine
Oleic acid~0.3–0.55%
Irritant · medium
Irritation risk
Medium
Works for
CleansingAnti-inflammatoryMoisturizing

Helps soften the upper layer of the skin. At the same time, it can weaken the skin's barrier enhancing penetration of other ingredients and increasing the risk of skin dryness

More about Oleic acid
Palmitic acid~0.3–0.55%
Formula
Irritation risk
Low
Works for
CleansingMoisturizing

An emollient that is naturally present in skin and helps soften it

More about Palmitic acid
Tocopherol~0.25–0.5%
Formula
Irritation risk
Low
Works for
Anti-oxidationAnti-agingAnti-inflammatoryMoisturizing

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol
Mevalonolactone~0.25–0.5%
Formula
Hydrogenated phosphatidylcholine~0.25–0.5%
Irritant · medium
Irritation risk
Medium
Works for
Cleansing

Helps oil and water mix together

More about Hydrogenated phosphatidylcholine
Linoleic acid~0.4–0.6%
Under-dosed
Irritation risk
Low
Works for
MoisturizingCleansingAnti-blemish

An excellent emollient. Helps soften the skin, restore its barrier function, and can help to calm down inflammation. It can be helpful to prevent blemishes and clogged pores

More about Linoleic acid
Sodium pca~0.25–0.45%
Key active
Irritation risk
Low
Works for
Moisturizing

Naturally present in skin and helps to attract water to its upper layer

More about Sodium pca
Serine~0.25–0.45%
Key active
Irritation risk
Low
Works for
MoisturizingAnti-aging

An amino-acid that helps to attract water to the upper layer of the skin. In combination with other amino-acids, might help to reduce fine lines and wrinkles

More about Serine
Glycine~0.25–0.4%
Key active
Irritation risk
Low
Works for
Moisturizing

Helps to attract water to the upper layer of the skin and can help restore the skin barrier function

More about Glycine
Tremella fuciformis polysaccharide~0.25–0.45%
Formula
Rosa canina fruit extract~0.2–0.4%
Irritant · medium
Irritation risk
Medium
Works for
Anti-oxidation

A plant extract that might have some anti-oxidant properties, but evidence is lacking

More about Rosa canina fruit extract
Ceramide np~0.25–0.45%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-inflammatoryReduces irritation

A type of lipid similar to ceramides naturally present in skin. Helps to soften the upper layer of the skin and supports the skin barrier function to keep it hydrated. Can help to prevent inflammation in skin

More about Ceramide np
Alanine~0.15–0.3%
Key active
Irritation risk
Low
Works for
MoisturizingEvens skin tone

An amino-acid that helps to attract water to the upper layer of the skin and might help to lighten the skin, but solid evidence is lacking

More about Alanine
Glutamic acid~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

An amino-acid that helps attract water to the upper layer of the skin

More about Glutamic acid
Cholesteryl macadamiate~0.2–0.4%
Formula
Sucrose stearate~0.2–0.4%
Formula
Irritation risk
Low
Works for
Cleansing

Helps water and oil mix together

More about Sucrose stearate
Phytosphingosine~0.15–0.3%
Hero · Moisturizing
Irritation risk
Low
Works for
MoisturizingAnti-blemishAnti-inflammatory

A type of lipid that is naturally present in skin. It might help in repairing skin barrier function and has anti-bacterial effect

More about Phytosphingosine
Glycosphingolipids~0.15–0.3%
Key active
Irritation risk
Low
Works for
Moisturizing

A type of lipids naturally present in skin. They can be converted to ceramides in skin

More about Glycosphingolipids
Ingredient list view

Water, Caprylic/capric triglyceride, Butylene glycol, Glycerin, Pentaerythrityl tetraisostearate, 1,2-hexanediol, Glyceryl stearate se, Cetyl alcohol, Stearyl alcohol, Cetearyl olivate, Cholesterol, Sorbitan sesquioleate, Olea europaea fruit oil, Sorbitan olivate, Hydroxypropyl bispalmitamide mea, Stearic acid, Carbomer, Ethylhexylglycerin, Myristyl alcohol, Arginine, Isomerized linoleic acid, Lauryl alcohol, Decylene glycol, Caprylyl glycol, Xanthan gum, Adenosine, Oleic acid, Palmitic acid, Tocopherol, Mevalonolactone, Hydrogenated phosphatidylcholine, Linoleic acid, Sodium pca, Serine, Glycine, Tremella fuciformis polysaccharide, Rosa canina fruit extract, Ceramide np, Alanine, Glutamic acid, Cholesteryl macadamiate, Sucrose stearate, Phytosphingosine, Glycosphingolipids

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Amazon USPrice as of 10/9/2026 21:06 GMT
$24.99
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$27.18
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Worth comparing, line by line.

Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.

Side-by-side comparison of this product against its closest alternatives
Dr.Different113 MoisturizerYOUR PRODUCTKLAVUURejuve Pearlsation Multi Pearl Peptide CreamIt'S SKINPower 10 Formula Powerful Genius CreamI'm fromRice Cream
Match—54%53%53%
Price$24.99$29.10+$4.11$23.04−$1.95$28.87+$3.88
Shared key ingredients—10 of 1610 of 165 of 16
Key difference—NiacinamideNiacinamidePanthenol
Irritancy Medium Medium Medium Low
Drying alcohol————
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Product summary

Based on the ingredient list, "Dr. Different - 113 Moisturizer" can work well for skin moisturization. The formulation is based on a combination of good humectants and emollients. Both are needed to increase the skin hydration level. Alanine, arginine, glutamic acid, glycerin and glycine in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (ceramide np, phytosphingosine, cholesterol, glycosphingolipids and hydroxypropyl bispalmitamide mea) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.

Ingredient callouts

  • Another benefit is that this moisturizer contain ceramides (phytosphingosine 0.15% - 0.30% and ceramide np 0.25% - 0.45%). Ceramides are an important part of our natural skin barrier. The Ceramides used in skincare are synthetic or come from plants. They help soften the skin and can help "fill the gaps" in the skin barrier, keeping the skin hydrated and resilient for longer.
  • Adenosine 0.25% - 0.45%. It is a compound that in involved in many biological processes inside the skin cells. According one high-quality clinical trial, topical Adenosine in low concentrations can somewhat help improve "deep wrinkles" - the wrinkles that appear with age in places where our faces are most dynamic (for example, on the forehead or in the corners of the eyes).
This product contains ingredients that could be beneficial, but their concentrations are too low in this formulation: vitamin e and stearic acid

Irritation risk

There are some common irritants in this product, including ingredients that do not have benefits for the skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here

You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.

Price

The product retails from 27.18$ up to 37.00$ in the United States.

For a detailed price comparison: click here.

Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 21 studies and safety reviews.

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As an Amazon Associate, WIMJ earns from qualifying purchases.