Works for
Anti-agingPalmitoyl tripeptide-5, Arabidopsis thaliana extract + 5 moreWorks well
“Predermine Wrinkle Repair Serum”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains acetyl glucosamine.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-8, arabidopsis thaliana extract, palmitoyl tripeptide-1, palmitoyl tripeptide-5.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
MoisturizingPalmitoyl tripeptide-5, Palmitoyl tripeptide-1 + 17 moreWorks well
“The non-comedogenic serum avoids clogging your pores, while hyaluronic acid works to drench your complexion in hydration.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
biosaccharide gum-1, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: palmitoyl tripeptide-1, ethylhexyl palmitate.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl glucosamine, acetyl hexapeptide-8, palmitoyl tripeptide-1, palmitoyl tripeptide-5
Evens skin toneSide benefit · Acetyl glucosamine, Glycine soja proteinWorks well
This product can help reduce hypepigmentation and even out the skin tone because it contains the following effective ingredients: acetyl glucosamine
The following ingredient (ingredients) in this product might be helpful, but there is no evidence to confirm that it actually can help even out the skin tone: glycine soja protein.
Keep in mind that you would need to apply any topical skincare targetted at hypigmentation consistently for a couple of months to get a result. No topical skincare product can help get rid of hyperpigmentation (including post-acne marks and age spots) instantly.
Can it cause trouble?
Irritancy11 strong irritants: Peucedanum graveolens extract, Equisetum arvense extract + 9 more — patch-test recommendedHigh risk
Comedogenic2 ingredients rated 2 or more on the 0–5 pore-clogging scale2 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Glycereth-26~5.2–6.4%
Glycerin~3.9–4.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinButylene glycol~3–3.6%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolPropanediol~2.3–2.8%
- Irritation risk
- Low
Acts as a solvent for other ingredients. Speeds up the absorption of other ingredients into the skin
More about PropanediolMicrocrystalline cellulose~1.8–2.2%
Peucedanum graveolens extract~1.5–1.8%
- Irritation risk
- High
A plant extract. Might have an antioxidant effect. Can be used as a fragrance
More about Peucedanum graveolens extractPalmitoyl tripeptide-5~1.4–1.7%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-5Menyanthes trifoliata leaf extract~1.1–1.4%
- Irritation risk
- Low
Hordeum vulgare extract~0.95–1.2%
- Irritation risk
- Medium
A plant extract that might have some anti-oxidant properties. Avoid if you are sensitive to gluten
More about Hordeum vulgare extractIris florentina root extract~0.65–1%
- Irritation risk
- Low
Equisetum arvense extract~0.45–0.65%
- Irritation risk
- High
A plant extract that might have anti-oxidant properties. Can be irritating
More about Equisetum arvense extractPadina pavonica thallus extract~0.5–0.75%
- Irritation risk
- Low
- Comedogenicity
- 3/5
Might help to soften the upper layer of the skin. Is claimed to have anti-oxidant properties, but evidence in missing
More about Padina pavonica thallus extractArabidopsis thaliana extract~0.45–0.7%
- Irritation risk
- Medium
Plant extract that might be helpful in repairing sun damage but evidence of effectiveness in skin are lacking
More about Arabidopsis thaliana extractCaffeine~0.4–0.6%
- Irritation risk
- Medium
Might be helpful in neutralizing free radicals. Can have a dehydration effect that might somewhat decrease the look of puffy eyes
More about CaffeineSimmondsia chinensis seed oil~0.5–0.7%
- Irritation risk
- Medium
Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.
More about Simmondsia chinensis seed oilGlycine soja protein~0.45–0.65%
- Irritation risk
- Low
A plant extract that helps to attract water to the upper layer of the skin and soften it. It might be helpful in neutralizing free radicals. It might be somewhat helpful for evening out the skin tone. It might be able to support elastin production but solid research is lacking
More about Glycine soja proteinCucumis sativus fruit extract~0.3–0.6%
- Irritation risk
- Medium
Might be somewhat helpful in reducing hyperpigmentation and neutralizing free radicals but its typical concentration in a product is too low for having an effect
More about Cucumis sativus fruit extractHelianthus annuus seed extract~0.3–0.55%
- Irritation risk
- Low
Sigesbeckia orientalis extract~0.25–0.45%
- Irritation risk
- Medium
A plant extract that can contain an anti-inflammatory compound
More about Sigesbeckia orientalis extractSodium hyaluronate~0.25–0.5%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronatePropylene glycol dicaprate~0.3–0.55%
- Irritation risk
- Low
An emollient that helps soften the upper layer of the skin
More about Propylene glycol dicaprateMethyl gluceth-20~0.25–0.45%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin and soften it
More about Methyl gluceth-20Polysorbate 20~0.25–0.5%
Ethylhexyl palmitate~0.3–0.5%
- Irritation risk
- Low
- Comedogenicity
- 3/5
An emollient that helps soften the skin and create a nice product texture
More about Ethylhexyl palmitateLecithin~0.3–0.5%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinBiosaccharide gum-1~0.25–0.45%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin and is claimed to provide a longer-lasting hydration because of its ability to create a water-binding film on the surface of the skin
More about Biosaccharide gum-1Acetyl glucosamine~0.25–0.4%
- Irritation risk
- Low
An effective moisturizing ingredient that also has been shown to be effective in evening out the skin tone and reducing hyperpigmentation. It can help somewhat reduce wrinkles in skin
More about Acetyl glucosamineAcetyl hexapeptide-8~0.25–0.4%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Caprylyl glycol~0.25–0.5%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolTocopheryl acetate~0.25–0.45%
- Irritation risk
- Medium
A more stable but less bio-available form of vitamin E compared to Tocopherol. Might help moisturize and protect the skin from free radicals, but mostly used in low concentrations to stabilize other ingredients.
More about Tocopheryl acetateEthylhexylglycerin~0.25–0.45%
Sodium acrylates copolymer~0.2–0.4%
- Irritation risk
- Medium
Used to create a thicker product consistency
More about Sodium acrylates copolymerIsostearyl alcohol~0.25–0.5%
- Irritation risk
- Low
Helps soften the upper layer of the skin
More about Isostearyl alcoholCellulose gum~0.25–0.5%
- Irritation risk
- Low
Used to create thicker product consistency and stabilize emulsions
More about Cellulose gumPalmitoyl tripeptide-1~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Polyacrylate-13~0.25–0.5%
- Irritation risk
- Low
Used to create a thicker product consistency and stabilize the product formulation
More about Polyacrylate-13Butylene glycol cocoate~0.25–0.45%
- Irritation risk
- Medium
Helps oil and water mix together
More about Butylene glycol cocoateHydrogenated lecithin~0.25–0.45%
- Irritation risk
- Low
Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.
More about Hydrogenated lecithinSodium hydroxide~0.25–0.45%
Polyisobutene~0.25–0.5%
Xanthan gum~0.25–0.45%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumTocopherol~0.25–0.45%
- Irritation risk
- Low
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
More about TocopherolCarbomer~0.25–0.45%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerEthylcellulose~0.25–0.45%
- Irritation risk
- Low
Silica dimethyl silylate~0.25–0.5%
Calcium chloride~0.2–0.4%
- Irritation risk
- Medium
Helps create a thicker product consistency. Might be irritating
More about Calcium chlorideParfum~0.2–0.35%
- Irritation risk
- High
An aromatic blend of unspecified and possibly irritating ingredients
More about ParfumCitronellol~0.2–0.35%
Alpha-isomethyl ionone~0.2–0.35%
- Irritation risk
- High
A fragrance. Potential allergen and can be irritating
More about Alpha-isomethyl iononeBenzyl salicylate~0.15–0.3%
Geraniol~0.15–0.3%
Linalool~0.15–0.3%
Limonene~0.15–0.25%
- Irritation risk
- High
A common frangrance that can easily irritate skin, especially if exposed to air, light or heat
More about LimoneneHexyl cinnamal~0.1–0.2%
Hydroxycitronellal~0.15–0.25%
- Irritation risk
- High
A fragrance. A likely allergen and can be irritating
More about HydroxycitronellalDisodium edta~0.1–0.2%
Potassium sorbate~0.1–0.25%
Phenoxyethanol~0.1–0.2%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolIngredient list view
Water, Glycereth-26, Glycerin, Butylene glycol, Propanediol, Microcrystalline cellulose, Peucedanum graveolens extract, Palmitoyl tripeptide-5, Menyanthes trifoliata leaf extract, Hordeum vulgare extract, Iris florentina root extract, Equisetum arvense extract, Padina pavonica thallus extract, Arabidopsis thaliana extract, Caffeine, Simmondsia chinensis seed oil, Glycine soja protein, Cucumis sativus fruit extract, Helianthus annuus seed extract, Sigesbeckia orientalis extract, Sodium hyaluronate, Propylene glycol dicaprate, Methyl gluceth-20, Polysorbate 20, Ethylhexyl palmitate, Lecithin, Biosaccharide gum-1, Acetyl glucosamine, Acetyl hexapeptide-8, Unknown, Caprylyl glycol, Tocopheryl acetate, Ethylhexylglycerin, Sodium acrylates copolymer, Isostearyl alcohol, Cellulose gum, Palmitoyl tripeptide-1, Polyacrylate-13, Butylene glycol cocoate, Hydrogenated lecithin, Sodium hydroxide, Polyisobutene, Xanthan gum, Tocopherol, Carbomer, Ethylcellulose, Silica dimethyl silylate, Calcium chloride, Parfum, Citronellol, Alpha-isomethyl ionone, Benzyl salicylate, Geraniol, Linalool, Limonene, Hexyl cinnamal, Hydroxycitronellal, Disodium edta, Potassium sorbate, Phenoxyethanol
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| DarphinPredermine Wrinkle Repair SerumYOUR PRODUCT | CliniqueSmart Wrinkle Correcting Serum All Skin Types | BlissPro Youth Serum | SKINCITY skincareMulti Action Serum | |
|---|---|---|---|---|
| Match | — | 57% | 56% | 56% |
| Price | $124.00 | $80.00−$44.00 | — | — |
| Shared key ingredients | — | 7 of 12 | 6 of 12 | 5 of 12 |
| Key difference | — | Hydroxypinacolone Retinoate | Hexapeptide-9 | Acetyl Hexapeptide-1 |
| Irritancy | High | Medium | Medium | Medium |
| Drying alcohol | — | — | — | Contains drying alcohol |
| View product | Shop | Shop | Shop |
More alternatives: Medik8 Liquid PeptidesBoots Firming Peptides and Beta Glucan Serum
Product summary
"Darphin - Predermine Wrinkle Repair Serum" is effective for: Evens skin tone, Anti-aging and Moisturizing
Ingredient callouts
- Peptides (palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine 1.10% - 1.40%). Peptides are a very big group of ingredients. They all consist of a different combination of aminoacids. Our skin produces Peptides naturally. Some of them work as natural antibiotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of Peptides is, but it is very likely that theynare helpful. Peptides might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
- Humectants (acetyl glucosamine 0.20% - 0.40%, sodium hyaluronate 0.25% - 0.40%, faex 0.20% - 0.40%, algae extract 0.60% - 0.85% and glycerin 2.00% - 2.40%). These ingredients help attract water to the upper layer of the skin and improve the skin hydration.
Price
The product retails for 865.22A$ in Australia, for 107.58$ in the United States and from 87.95£ up to 120.00£ in the United Kingdom.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 20 studies and safety reviews.
- 1
- 2
- 3Celiac Disease & Skin Care Productsbadgut.org
- 4
- 5Repair of Damaged DNA by Arabidopsis Cell Extractncbi.nlm.nih.gov
- 6
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