Bioderma

Bioderma Créaline Defensive Soothing Active Cream

Name: Bioderma - Créaline Defensive Soothing Active Cream
Brand: Bioderma

Efficacy75/100IrritancyMedium

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Works for

1 of 1 advertised claim delivered

Moisturizing

14 ingredients credited for this claim

Good support

What the product description says

“Thus, the skin is immediately soothed, protected and moisturised.”

Source: Cocoon Center

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: carnosine, glycerin.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: squalane, glycine soja oil.

GlycerinKey active· HumectantEffect: HighOne of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant~4.2–6.4%

SqualaneKey active· Emollient, OcclusiveEffect: HighAn oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.~1.3–2%

CarnosineKey active· HumectantEffect: HighA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.2–0.8%

Glycine soja oilKey active· EmollientEffect: HighA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.~0.1–0.3%

Mangifera indica seed butterKey activeEffect: HighHelps to soften the upper layer of the skin and might have some anti-oxidant effect~0.55–1.35%

MannitolKey active· HumectantEffect: HighHelps to attract water to the upper layer of the skin~0.15–0.55%

Propylheptyl caprylateKey active· EmollientEffect: MediumHelps soften the upper layer of the skin~2.7–4.1%

RhamnoseKey active· HumectantEffect: MediumHelps oil and water mix together. It also helps attract water to the upper layer of the skin~0.05–0.3%

Butylene glycol· HumectantEffect: LowUsed to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin~2–3%

Glyceryl stearate citrate· EmollientEffect: LowHelps oil and water mix together while softening the upper layer of the skin~1.7–2.5%

Pentylene glycol· EmollientEffect: LowUsed to preserve products, dissolve other ingredients and create a nice product texture~0.5–1.15%

Dicaprylyl ether· EmollientEffect: LowHelps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients~3.6–5.4%

Caprylyl glycol· Humectant, EmollientEffect: LowHelps preserve products and creates a nice product texture~0.35–0.8%

TocopherolEffect: Low, below effective dosePure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.5%

Anti-oxidation

Not advertised by the brand · 3 ingredients credited for this claim

Strong support

This product contains antioxidants (carnosine) that can help neutralize free radicals in skin. By doing so, they can lessen the damage the skin gets from the UV light (sun).

CarnosineKey activeEffect: HighA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.2–0.8%

Mangifera indica seed butterEffect: LowHelps to soften the upper layer of the skin and might have some anti-oxidant effect~0.55–1.35%

TocopherolUnder-dosedEffect: HighPure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself~0.1–0.5%

Anti-aging

Not advertised by the brand · 3 ingredients credited for this claim

Moderate support

This product contains carnosine. This ingredient might be able to help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness, but there is not enough evidence that it actually works.

CarnosineKey activeEffect: MediumA type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage~0.2–0.8%

RhamnoseEffect: LowHelps oil and water mix together. It also helps attract water to the upper layer of the skin~0.05–0.3%

Can it cause trouble?

Irritancy

1 strong irritant: Salvia miltiorrhiza flower/leaf/root extract

Medium risk

We flagged 7 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.

IngredientFunctionIrritationEst. amount

Salvia miltiorrhiza flower/leaf/root extract—High~0.1–0.35%est.

Pentylene glycolUsed to preserve products, dissolve other ingredients and create a nice product textureMedium~0.5–1.15%est.

Acrylates/c10-30 alkyl acrylate crosspolymerMaintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix togetherMedium~0.4–0.9%est.

Caprylyl glycolHelps preserve products and creates a nice product textureMedium~0.35–0.8%est.

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymerA gelling agent that thickens the product consistency and leaves the skin with a velvety finishMedium~0.15–0.65%est.

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.Medium~0.1–0.3%est.

Polysorbate 60Helps oil and water mix togetherMedium~0.05–0.25%est.

Comedogenic

1 ingredient rated 2 or more on the 0–5 pore-clogging scale

1 flagged

These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.

IngredientFunctionRatingEst. amount

Glycine soja oilA good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.2/5~0.1–0.3%est.

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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%

Formula

Irritation risk: Low

Plain old water

More about Water

Glycerin~4.2–6.4%

Key active

Irritation risk: Low

Works for

Moisturizing

One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant

More about Glycerin

Dicaprylyl ether~3.6–5.4%

Formula

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin while creating a non-greasy feel on the skin. Helps to dissolve other ingredients

More about Dicaprylyl ether

Propylheptyl caprylate~2.7–4.1%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps soften the upper layer of the skin

More about Propylheptyl caprylate

Butylene glycol~2–3%

Formula

Irritation risk: Low

Works for

Moisturizing

Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin

More about Butylene glycol

Glyceryl stearate citrate~1.7–2.5%

Formula

Irritation risk: Low

Works for

CleansingMoisturizing

Helps oil and water mix together while softening the upper layer of the skin

More about Glyceryl stearate citrate

Glycol palmitate~1.4–2%

Formula

Irritation risk: Low

Works for

Cleansing

More about Glycol palmitate

Squalane~1.3–2%

Key active

Irritation risk: Low

Works for

Moisturizing

An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.

More about Squalane

Sucrose stearate~1–1.5%

Formula

Irritation risk: Low

Works for

Cleansing

Helps water and oil mix together

More about Sucrose stearate

Mangifera indica seed butter~0.55–1.35%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-oxidation

Helps to soften the upper layer of the skin and might have some anti-oxidant effect

More about Mangifera indica seed butter

Pentylene glycol~0.5–1.15%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Used to preserve products, dissolve other ingredients and create a nice product texture

More about Pentylene glycol

Acrylates/c10-30 alkyl acrylate crosspolymer~0.4–0.9%

Irritant · medium

Irritation risk: Medium

Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together

More about Acrylates/c10-30 alkyl acrylate crosspolymer

Caprylyl glycol~0.35–0.8%

Irritant · medium

Irritation risk: Medium

Works for

Moisturizing

Helps preserve products and creates a nice product texture

More about Caprylyl glycol

Carnosine~0.2–0.8%

Key active

Irritation risk: Low

Works for

Anti-oxidationMoisturizingAnti-aging

A type of peptide. It attracts water to the upper layer of the skin. It can help neutralize free radicals in skin combatting the sun damage

More about Carnosine

Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer~0.15–0.65%

Irritant · medium

Irritation risk: Medium

A gelling agent that thickens the product consistency and leaves the skin with a velvety finish

More about Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer

Mannitol~0.15–0.55%

Key active

Irritation risk: Low

Works for

Moisturizing

Helps to attract water to the upper layer of the skin

More about Mannitol

Xylitol~0.1–0.5%

Formula

Irritation risk: Low

Helps attract water to the upper layer of the skin and repair the skin barrier function

More about Xylitol

Tocopherol~0.1–0.5%

Under-dosed

Irritation risk: Low

Works for

Anti-oxidationAnti-agingMoisturizingAnti-inflammatory

Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself

More about Tocopherol

Salvia miltiorrhiza flower/leaf/root extract~0.1–0.35%

Irritant · high

Irritation risk: High

More about Salvia miltiorrhiza flower/leaf/root extract

Rhamnose~0.05–0.3%

Key active

Irritation risk: Low

Works for

MoisturizingAnti-aging

Helps oil and water mix together. It also helps attract water to the upper layer of the skin

More about Rhamnose

Glycine soja oil~0.1–0.3%

Key activeComedogenic 2/5Irritant · medium

Irritation risk: Medium
Comedogenicity: 2/5

Works for

Moisturizing

A good emollient that helps soften the skin and helps repair its barrier function. It can clog pores if used in high concentrations.

More about Glycine soja oil

Polysorbate 60~0.05–0.25%

Irritant · medium

Irritation risk: Medium

Works for

Cleansing

Helps oil and water mix together

More about Polysorbate 60

Sorbitan isostearate~0.05–0.15%

Formula

Irritation risk: Low

Works for

Cleansing

Helps oil and water mix together

More about Sorbitan isostearate

Palmitoyl tetrapeptide-10~0.01–0.1%

Formula

Irritation risk: Low

More about Palmitoyl tetrapeptide-10

Ingredient list view

Water, Glycerin, Dicaprylyl ether, Propylheptyl caprylate, Butylene glycol, Glyceryl stearate citrate, Glycol palmitate, Squalane, Sucrose stearate, Mangifera indica seed butter, Pentylene glycol, Acrylates/c10-30 alkyl acrylate crosspolymer, Caprylyl glycol, Carnosine, Hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, Mannitol, Xylitol, Tocopherol, Salvia miltiorrhiza flower/leaf/root extract, Rhamnose, Glycine soja oil, Polysorbate 60, Sorbitan isostearate, Palmitoyl tetrapeptide-10

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Cocoon Center

≈ $20.06

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Amazon UKPrice as of 10/17/2026 21:02 GMT

≈ $26.60

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 8 studies and safety reviews.

1
Glycerol and the skin: holistic approach to its origin and functionsncbi.nlm.nih.gov
2
Extraction and Characteristics of Seed Kernel Oil from Mangopdfs.semanticscholar.org
3
Promising features of mango (Mangifera indica L.) kernel oil: a reviewncbi.nlm.nih.gov
4
Evaluation of the fatty acid composition of the seeds of Mangifera indica L. and their applicationncbi.nlm.nih.gov
5
Biological activities of the natural imidazole-containing peptidomimetics n-acetylcarnosine, carcinine and l-carnosine in ophthalmic and skin care productssciencedirect.com
6
Vitamin E in dermatologyncbi.nlm.nih.gov
7
Vitamin E and Skin Healthlpi.oregonstate.edu
8
Potentially beneficial effects of rhamnose on skin ageing: an in vitro and in vivo studypubmed.ncbi.nlm.nih.gov

BiodermaCréaline Defensive Soothing Active Cream

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