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ADVANCED CLINICALS Vein Care Cream
ADVANCED CLINICALS

ADVANCED CLINICALS Vein Care Cream

Efficacy75/100IrritancyMedium
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Works for

1 of 1 advertised claim delivered

Moisturizing
Helianthus annuus seed oil, Soluble collagen + 4 more
Good evidence
What the product description says
“95 Notify me when this product is available Transform the look of tired eyes with this rapid soothing, hydrating serum.”
Source: Advanced Clinicals

This product can help improve hydration of the skin with the two types of ingredients.

The first type is called “humectants”:
these ingredients help attract water. When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from within deeper layers of the skin. The following ingredients in this product do the job: soluble collagen.

This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: helianthus annuus seed oil, cetearyl alcohol.

Helianthus annuus seed oilKey active· Emollient, OcclusiveEffect: HighA great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function~0.85–1.25%
Soluble collagenKey active· HumectantEffect: HighA typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin~0.4–0.95%
Cetearyl alcoholKey active· EmollientEffect: MediumA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture~5.7–8.5%
Chlorella vulgaris extractKey activeEffect: MediumA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties~2–3%
Ethylhexyl stearate· EmollientEffect: LowHelps soften the upper layer of the skin~1.3–1.9%
Camellia sinensis leaf extractEffect: Low, below effective doseCan contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation~0.2–0.75%

Can it cause trouble?

Irritancy
1 strong irritant: Parfum
Medium risk
We flagged 6 ingredients with irritancy potential. Severity depends on your sensitivity threshold; the table lists the worst offenders first.
IngredientFunctionIrritationEst. amount
ParfumAn aromatic blend of unspecified and possibly irritating ingredientsHigh~0.05–0.15%est.
Ceteareth-20Helps oil and water mix together. Has some emollient propertiesMedium~3.6–5.4%est.
Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory propertiesMedium~2–3%est.
Tapioca starchUsed to create a thicker product consistencyMedium~1.4–2.2%est.
Potassium sorbateA preservativeMedium~0.15–0.5%est.
Citric acidCan work as an exfoliant but is typically used to adjust the product pHMedium~0.01–0.05%est.
Comedogenic
3 ingredients rated 2 or more on the 0–5 pore-clogging scale
3 flagged
These ingredients have a comedogenic rating of 2 or more on a 0–5 scale; the table shows each one's rating. In leave-on products they can clog pores in acne-prone skin.
IngredientFunctionRatingEst. amount
Chlorella vulgaris extractA plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties3/5~2–3%est.
Cetearyl alcoholA non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture2/5~5.7–8.5%est.
Ceteareth-20Helps oil and water mix together. Has some emollient properties2/5~3.6–5.4%est.
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Ingredients

Filter by role to see what each ingredient is doing.

Water~40–60%
Formula
Irritation risk
Low

Plain old water

More about Water
Cetearyl alcohol~5.7–8.5%
Key activeComedogenic 2/5
Irritation risk
Low
Comedogenicity
2/5
Works for
CleansingMoisturizing

A non-drying alcohol. Works as an emollient. Helps water and oil mix together and creates a nice product texture

More about Cetearyl alcohol
Ceteareth-20~3.6–5.4%
Comedogenic 2/5Irritant · medium
Irritation risk
Medium
Comedogenicity
2/5
Works for
Cleansing

Helps oil and water mix together. Has some emollient properties

More about Ceteareth-20
Sodium polyacrylate~2.7–4.1%
Formula
Irritation risk
Low
Works for
Mattifying

Used to create a gel-like product texture, as well as to stabilize emulsions

More about Sodium polyacrylate
Chlorella vulgaris extract~2–3%
Key activeComedogenic 3/5Irritant · medium
Irritation risk
Medium
Comedogenicity
3/5
Works for
MoisturizingAnti-oxidationAnti-inflammatory

A plant extract that can help to attract water to the upper layer of the skin and might have some anti-oxidant and anti-inflammatory properties

More about Chlorella vulgaris extract
Tapioca starch~1.4–2.2%
Irritant · medium
Irritation risk
Medium

Used to create a thicker product consistency

More about Tapioca starch
Ethylhexyl stearate~1.3–1.9%
Formula
Irritation risk
Low
Works for
Moisturizing

Helps soften the upper layer of the skin

More about Ethylhexyl stearate
Trideceth-6~0.9–1.3%
Formula
Irritation risk
Low
Works for
Cleansing

Helps oil and water mix together

More about Trideceth-6
Helianthus annuus seed oil~0.85–1.25%
Key active
Irritation risk
Low
Works for
Moisturizing

A great emollient due to its high linoleic acid content. One of the most effective plant oils in helping skin hydration and repairing skin barrier function

More about Helianthus annuus seed oil
Soluble collagen~0.4–0.95%
Key active
Irritation risk
Low
Works for
Moisturizing

A typically plant-derived compound that is supposed mimic human collagen. Cannot penetrate the skin barrier so is not particularly useful in skincare products beyond attracting water to the upper layer of the skin

More about Soluble collagen
Camellia sinensis leaf extract~0.2–0.75%
Formula
Irritation risk
Low
Works for
AntibacterialAnti-oxidationAnti-agingMoisturizingEvens skin toneAnti-blemish

Can contain potent anti-oxidant compounds (abbreviated ECG, GCG, EGC, and EGCG) that might help protect the skin from free radicals. Can help calm down inflammation and has some anti-bacterial properties. Unfortunately, these antioxidants are unstable and lose their effectiveness very quickly in products. The concentration of the antioxidant compounds in the extract also tends to be low to be effective in topical formulation

More about Camellia sinensis leaf extract
Potassium sorbate~0.15–0.5%
Irritant · medium
Irritation risk
Medium

A preservative

More about Potassium sorbate
Sodium benzoate~0.1–0.3%
Formula
Irritation risk
Low

A preservative

More about Sodium benzoate
Parfum~0.05–0.15%
Irritant · high
Irritation risk
High

An aromatic blend of unspecified and possibly irritating ingredients

More about Parfum
Citric acid~0.01–0.05%
Irritant · medium
Irritation risk
Medium

Can work as an exfoliant but is typically used to adjust the product pH

More about Citric acid
Ingredient list view

Water, Cetearyl alcohol, Ceteareth-20, Sodium polyacrylate, Chlorella vulgaris extract, Tapioca starch, Ethylhexyl stearate, Trideceth-6, Helianthus annuus seed oil, Soluble collagen, Camellia sinensis leaf extract, Potassium sorbate, Sodium benzoate, Parfum, Citric acid

Compare prices

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Advanced Clinicals
$10.00
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Amazon USPrice as of 10/26/2026 18:17 GMT
$13.99
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Affiliate links · prices updated regularly · As an Amazon Associate, WIMJ earns from qualifying purchases.

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Sources cited in this review

Every concentration estimate and effectiveness label is anchored to one of these 4 studies and safety reviews.

  1. 1
    Effect of Olive and Sunflower Seed Oil on the Adult Skin Barrier: Implications for Neonatal Skin Careonlinelibrary.wiley.com
  2. 2
    Topically Applied Sunflower Seed Oil Prevents Invasive Bacterial Infections in Preterm Infants in Egyptjournals.lww.com
  3. 3
    Effect of topically applied lipids on surfactant-irritated skinonlinelibrary.wiley.com
  4. 4
    Impact of topical oils on the skin barrier: possible implications for neonatal health in developing countriesonlinelibrary.wiley.com
ADVANCED CLINICALS Vein Care Cream
ADVANCED CLINICALSVein Care Cream
Buy at Advanced Clinicals$10.00$13.99as of 10/26 18:17 GMT

Affiliate links · As an Amazon Associate, WIMJ earns from qualifying purchases.

Buy at Advanced Clinicals$10.00$13.99as of 10/26 18:17 GMT

As an Amazon Associate, WIMJ earns from qualifying purchases.