JacobZA JacobZA
2 months ago

Vitamin C and Copper Peptides. The one or the other or both?

Hello everyone and thank you once again for letting me join this awesome platform. I have a question that I’ve been trying to research myself but with very little success, if any. It boils down to this: what is the best way for me to keep my vitamin C serum and my Buffet + Cu copper peptides both on my skin? Sources vary too much. Any experience?

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I think the best way is to use one of them in the night routine and the other in the morning. But if you want to use them both in the same routine you can wait 20-30 minutes. I usually prefer Vitamin C in the morning and peptides in the evening. Vice verse might work as well :)

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There is a web page about which ordinary products you can use together. They say not to use their vitamin C with the buffet + Cu. I've seen products with peptides and vitamin C in the same product so maybe it's something specific to their formulation. You could use vitamin C in the morning and the Buffet at night. Or you could alternate days.

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But see... 😂 now you understand my confusion.

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A bit of nerdy details to this question. This is where the advice to use Copper Peptides and Ascorbic Acid separately comes from: "Under the cell-free condition, copper is known to oxidize ascorbic acid (the active form of vitamin C) and the event leads to the loss of vitamin C. However, the biological consequence of this interaction was never examined in the presence of cells." (https://link.springer.com/article/10.1385/BTER:100:2:125#). My practical conclusion from this paper is the same as the other guys recommended here: using Cu and concentrated Ascorbic Acid in different steps (e.g. AM and PM)

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Heya! Thank you for replying. So what I have been doing lately (thank you, @ciltbakimyolculugum) is to limit my ascorbic acid to my morning routine and my peptides to my evening routjne, hoping and praying cu + peptides play along with tretinoin. (too scared to ask in case I get the answer I don't want 😂) so far so good.

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Sorry I had to do a Google Scholar search for this. On a positive side, I found nothing credible re actual chemical interaction between copper peptides and tretinoin, but there is a talk about an increased irritation risk if copper peptides and tretinoin are used in the same step. A dermatologist wrote in a paper in 2004: "Copper peptide may also be used in conjunction with Retin-A, although it should be applied at a different time of day to avoid mixing and dilution of the effectiveness of either product.", but he didn't add anything about the mechanism of the dillution of the effectiveness (https://academic.oup.com/asj/article/24/1/83/336426). From what I've read so far, it appears that one can use copper peptides and tretinoin in the same step if you are not worried about the irritation, but it might make sense to wait 10 min or so for the first product to sink into the skin just in case.

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Heya! As I've been using big guns on my skin and normally bite on my teeth and bear the irritation, I've grown accustomed to products with potent actives and the one or two times that I have mixed tretinoin 0.5 with ascorbic acid 20% 30 min after a 30%/2% AHA/BHA treatment, I felt nothing but a bit of sting. Okay maybe a lot of sting but great results. As far as Cu Peptides go, I myself have done broad reading and love getting other people's opinions about things. So thank you for your response. I have seen something (God knows where it is now) about the use of certain product with copper peptides, and the risk of a reaction rendering too much free copper in and around your skin/circulation or whatever (😂😝okay I just gave it away guys: I'm neither scientist nor doctor). But I am aware that too much of even a good thing, is bad. Experience talking. Not lessons from childhood. So I agree. Either copper peptides in the AM only and retinoids at night. If not that, then at least one episode of something on Netflix for the copper peptides to do its thing, followed by whatever it is that I was scared of - tretinoin, AA etc...

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