Peter Thomas Roth Peptide 21 Lift & Firm Moisturizer
Works for
MoisturizingHexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate + 39 moreWorks well
“Packed with 21 Peptides and Neuropeptides and 2 Gamma Proteins, this lightweight moisturizer delivers intense hydration and leaves skin feeling bouncy, firm, lifted and younger-looking.”
This product can help improve hydration of the skin with the two types of ingredients.
The first type is called “humectants”:
these ingredients help attract water.
When humectants are on the surface of the skin, they “pull in” the moisture from the outside environment, or from
within deeper layers of the skin. The following ingredients in this product do the job:
dextran, glycerin.
This product also contains ingredients called “occlusives”. They help reduce the speed with which our skin loses moisture to the outside environment. These ingredients also help soften the upper layer of the skin, so it feels less tight and nicer to the touch. The following ingredients in this product do the job: dimethicone, simmondsia chinensis seed oil.
The following ingredients in this product are especially good for supporting the skin barrier and helping with the hydration level: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-12, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline
Anti-agingHexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate + 17 moreWorks well
“Packed with 21 Peptides and Neuropeptides and 2 Gamma Proteins, this lightweight moisturizer delivers intense hydration and leaves skin feeling bouncy, firm, lifted and younger-looking.”
This product can help reduce and prevent fine lines and wrinkles, improve skin elasticity and firmness because it contains palmitoyl hexapeptide-12.
These ingredients in the product can also be helpful, even though there is less evidence for their effectiveness: acetyl hexapeptide-1, acetyl hexapeptide-8, acetyl octapeptide-3, acetyl tetrapeptide-11, acetyl tetrapeptide-2, acetyl tetrapeptide-9, dipeptide diaminobutyroyl benzylamide diacetate, hexapeptide-11, palmitoyl hexapeptide-19, palmitoyl oligopeptide, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, palmitoyl tripeptide-5, tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, trifluoroacetyl tripeptide-2, tripeptide-1, tripeptide-10 citrulline.
Keep in mind that it typically takes at least 6 weeks to notice any results because the changes that are needed to improve fine lines and elasticity happen in the deeper layers of the skin. No topical anti-aging product can “erase” wrinkles or fully reverse signs of aging.
Evens skin toneHydrolyzed soy proteinNot delivered
“Gamma Proteins harness the power of Asian natto gum, a breakthrough ingredient that helps improve the look of elasticity, radiance, uneven skin tone and texture.”
Effective ingredients missing or their concentration is too low
Anti-oxidationSide benefit · Squalene, Cereus grandiflorus flower extract + 2 moreMay help
This product contains antioxidants (cereus grandiflorus flower extract, squalene) that might be able to help neutralize free radicals in skin to lessen the damage it gets from the UV light (sun). There is not enough evidence to confirm their effectiveness in skin though.
Can it cause trouble?
Irritancy15 flagged ingredientsMedium risk
Comedogenic1 ingredient rated 2 or more on the 0–5 pore-clogging scale1 flagged
User reviews
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Ingredients
Filter by role to see what each ingredient is doing.
Water~45–55%
Glycerin~4.7–5.7%
- Irritation risk
- Low
One of the best moisturizing ingredients. Naturally present in skin. It attracts water to the upper layer of the skin working as a humectant
More about GlycerinDimethicone~4.2–5.1%
- Irritation risk
- Low
A silicone that helps to reduce water loss from the surface of the skin. Can temporarily "fill in" lines and wrinkles, absorb oil, and create a nice product finish
More about DimethiconeOlive oil decyl esters~3.1–3.7%
- Irritation risk
- Low
Glycereth-26~2.3–2.8%
Squalane~2–2.4%
- Irritation risk
- Low
An oil naturally present in skin. Works as an emollient to soften the skin and form a protective layer on its surface without a greasy feeling.
More about SqualaneButylene glycol~1.6–1.9%
- Irritation risk
- Low
Used to create a nice product texture and help delivery of other ingredients. Might be somewhat helpful in attracting water to the upper layer of the skin
More about Butylene glycolBehenyl alcohol~1.5–1.8%
- Irritation risk
- Low
Non-drying alcohol that helps water and oil mix together. Also serves as an emollient
More about Behenyl alcoholPolysilicone-11~1.2–1.5%
- Irritation risk
- Low
A silicone that forms a light film on the skin surface helping to bind water and temporarily absorb oils creating a matt and powdery feel
More about Polysilicone-11Batyl alcohol~1–1.2%
- Irritation risk
- Low
Non-drying alcohol. Used to stabilize other ingredients and is an emollient
More about Batyl alcoholSimmondsia chinensis seed oil~0.7–1.1%
- Irritation risk
- Medium
Softens the upper layer of skin and helps restore the healthy skin barrier. Has shown to help calm down inflammation in skin. It is a stable oil, meaning that it retains its properties even when exposed to air.
More about Simmondsia chinensis seed oilHexapeptide-11~0.55–0.8%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Hexapeptide-11Dipeptide diaminobutyroyl benzylamide diacetate~0.5–0.75%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Dipeptide diaminobutyroyl benzylamide diacetatePalmitoyl tripeptide-5~0.45–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-5Tripeptide-10 citrulline~0.4–0.6%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tripeptide-10 citrullineAcetyl hexapeptide-1~0.4–0.6%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-1Acetyl tetrapeptide-11~0.35–0.65%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl tetrapeptide-11Acetyl hexapeptide-8~0.3–0.6%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl hexapeptide-8Palmitoyl hexapeptide-12~0.3–0.55%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl hexapeptide-12Acetyl tetrapeptide-9~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl tetrapeptide-9Palmitoyl tetrapeptide-7~0.3–0.55%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tetrapeptide-7Acetyl tetrapeptide-2~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl tetrapeptide-2Acetyl octapeptide-3~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Acetyl octapeptide-3Palmitoyl hexapeptide-19~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl hexapeptide-19Trifluoroacetyl tripeptide-2~0.25–0.45%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Trifluoroacetyl tripeptide-2Tripeptide-1~0.25–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Tripeptide-1Palmitoyl oligopeptide~0.3–0.6%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl oligopeptidePalmitoyl tripeptide-1~0.3–0.5%
- Irritation risk
- Low
A type of peptide. Peptides are excellent moisturizers and might be able support collagen production reducing fine lines and wrinkles
More about Palmitoyl tripeptide-1Potassium hydrolyzed polygamma-glutamate~0.25–0.45%
- Irritation risk
- Low
Sodium polyglutamate~0.25–0.4%
- Irritation risk
- Low
Squalene~0.3–0.5%
- Irritation risk
- Low
- Comedogenicity
- 2/5
An oil that is naturally part of skin sebum that helps to soften its upper layer, reduce water loss and neutralize free radicals. It might be comedogenic. Avoid applying large concentrations (or pure oil) before sun exposure as oxidized squalene can clog pores and lead to skin irritation. Today squalene is mostly derived from vegetable oils or synthetized by yeast
More about SqualeneMica~0.3–0.5%
- Irritation risk
- Low
Creates an illusion of smoother and more radiant skin tone. Adds shimmer to the skin by reflecting light
More about MicaSodium hyaluronate~0.25–0.45%
- Irritation risk
- Low
One of the best moisturizing ingredients. Attracts water into the upper layer of the skin
More about Sodium hyaluronateSorbic acid~0.25–0.45%
Tocopherol~0.25–0.45%
- Irritation risk
- Low
Pure form of vitamin E. Can help moisturise and protect the skin from free radicals. Often used to help stabilise other ingredients or the formula itself
More about TocopherolCereus grandiflorus flower extract~0.25–0.45%
- Irritation risk
- Medium
A cactus extract that can help neutralize free radicals because it contains a chemical compound called betacyanins and flavonolglycosides. Can help make the surface of the skin dryer helping make pores look smaller for a very short period of time. The concentrations usually used in cosmetics are too small to have any effect
More about Cereus grandiflorus flower extractPseudoalteromonas ferment extract~0.25–0.45%
- Irritation risk
- Low
Leuconostoc/radish root ferment filtrate~0.25–0.45%
- Irritation risk
- Medium
A preservative that comes from radishes fermented by a bacteria. New research suggests that the preservation properties in the ingredient come from an ammonium salt that is not present naturally in radish root but used in its cultivation. Is problematic because the exact amount of the preservative agents is difficult to determine
More about Leuconostoc/radish root ferment filtrateMagnesium chloride~0.25–0.45%
Phenoxyethanol~0.25–0.45%
- Irritation risk
- Low
A preservative. It helps prevent bacterial growth in cosmetic products
More about PhenoxyethanolCetyl alcohol~0.3–0.55%
- Irritation risk
- Low
A non-drying alcohol that works to soften the skin and stabilize product formulations helping oil and water mix together
More about Cetyl alcoholStearyl alcohol~0.3–0.55%
- Irritation risk
- Low
An emollient that helps soften the skin
More about Stearyl alcoholTrehalose~0.25–0.45%
- Irritation risk
- Low
A sugar that attracts water to the upper layer of the skin
More about TrehaloseGlyceryl stearate~0.3–0.55%
- Irritation risk
- Low
An emollient that softens the skin and forms a protective layer on its surface. Helps water and oil mix together
More about Glyceryl stearateSilanetriol trehalose ether~0.25–0.5%
- Irritation risk
- Low
Mannitol~0.25–0.45%
- Irritation risk
- Low
Helps to attract water to the upper layer of the skin
More about MannitolPhytosterols~0.3–0.55%
- Irritation risk
- Medium
Lipids that work as an emollient and can be helpful in repairing skin barrier function
More about PhytosterolsAcrylates/c10-30 alkyl acrylate crosspolymer~0.25–0.5%
- Irritation risk
- Medium
Maintains the texture of skincare products. Allows the product to spread evenly. Helps oil and water mix together
More about Acrylates/c10-30 alkyl acrylate crosspolymerCaprylic/capric triglyceride~0.3–0.55%
- Irritation risk
- Medium
A good mix of fatty acids that forms a protective layer on the skin. Improves the shelf life of products. Derived from coconut and glycerin
More about Caprylic/capric triglycerideHydrogenated lecithin~0.25–0.5%
- Irritation risk
- Low
Helps to retain moisture by creating a protective barrier on the skin. Rich in fatty acids. Improves product texture and helps with the penetration of other ingredients.
More about Hydrogenated lecithinPolyglyceryl-10 myristate~0.25–0.45%
- Irritation risk
- Low
Polysorbate 20~0.25–0.5%
Dimethyl isosorbide~0.25–0.45%
- Irritation risk
- Low
Used to dissolve other ingredients in a product and can enhance their ability to penetrate the skin
More about Dimethyl isosorbideSodium benzoate~0.25–0.45%
Potassium sorbate~0.25–0.45%
Caprylyl glycol~0.25–0.5%
- Irritation risk
- Medium
Helps preserve products and creates a nice product texture
More about Caprylyl glycolSodium hydroxide~0.25–0.45%
Laureth-12~0.25–0.5%
Hydrolyzed wheat protein~0.2–0.4%
- Irritation risk
- Medium
Can help attract water to the upper layer of the skin. Avoid if sensitive to gluten
More about Hydrolyzed wheat proteinLecithin~0.25–0.5%
- Irritation risk
- Low
Used mostly for creating emulsions - helping oil and water mix together. Helps soften the upper layer of the skin
More about LecithinDisodium phosphate~0.2–0.4%
- Irritation risk
- Low
Helps adjust the product pH and stabilize the formulation
More about Disodium phosphateHydrolyzed soy protein~0.2–0.4%
- Irritation risk
- Low
Helps attract water to the upper layer of the skin. Might have some anti-aging, anti-oxidant, and skin lightening properties, but solid evidence is missing
More about Hydrolyzed soy proteinCarbomer~0.2–0.4%
- Irritation risk
- Low
Helps create a thicker or gel-like product texture. It is not a surfactant but can be used in gentle cleansing formulations
More about CarbomerDextran~0.2–0.35%
- Irritation risk
- Low
Helps attract water to the most upper layer of the skin. Derived from sugar
More about DextranEthylhexylglycerin~0.2–0.35%
Sodium lactate~0.15–0.3%
- Irritation risk
- Medium
Helps attract water to the upper layer of the skin. Is often used to adjust the pH level of the product
More about Sodium lactateTetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate~0.15–0.3%
- Irritation risk
- Low
A peptide. It helps attract water to the upper layer of the skin, support skin's barrier function and might have some slight anti-aging effect through stimulating skin's own production of hyaluronic acid
More about Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetateSodium phosphate~0.15–0.3%
Xanthan gum~0.15–0.25%
- Irritation risk
- Low
Used to create a thicker product consistency
More about Xanthan gumTriethanolamine~0.1–0.15%
- Irritation risk
- Medium
Used to adjust pH of the product and can help improve the product's smell
More about TriethanolamineAcrylates copolymer~0.1–0.15%
- Irritation risk
- Medium
Used to stabilize product formulation, help create an even product layer over skin (for example, in sunscreen) and create a thicker product consistency
More about Acrylates copolymerIngredient list view
Water, Glycerin, Dimethicone, Olive oil decyl esters, Glycereth-26, Squalane, Butylene glycol, Behenyl alcohol, Polysilicone-11, Batyl alcohol, Simmondsia chinensis seed oil, Hexapeptide-11, Dipeptide diaminobutyroyl benzylamide diacetate, Palmitoyl tripeptide-5, Tripeptide-10 citrulline, Acetyl hexapeptide-1, Acetyl tetrapeptide-11, Acetyl hexapeptide-8, Palmitoyl hexapeptide-12, Acetyl tetrapeptide-9, Palmitoyl tetrapeptide-7, Acetyl tetrapeptide-2, Acetyl octapeptide-3, Palmitoyl hexapeptide-19, Trifluoroacetyl tripeptide-2, Tripeptide-1, Palmitoyl oligopeptide, Palmitoyl tripeptide-1, Potassium hydrolyzed polygamma-glutamate, Sodium polyglutamate, Squalene, Mica, Sodium hyaluronate, Sorbic acid, Tocopherol, Cereus grandiflorus flower extract, Pseudoalteromonas ferment extract, Leuconostoc/radish root ferment filtrate, Magnesium chloride, Phenoxyethanol, Cetyl alcohol, Stearyl alcohol, Trehalose, Glyceryl stearate, Silanetriol trehalose ether, Mannitol, Phytosterols, Acrylates/c10-30 alkyl acrylate crosspolymer, Caprylic/capric triglyceride, Hydrogenated lecithin, Polyglyceryl-10 myristate, Polysorbate 20, Dimethyl isosorbide, Sodium benzoate, Potassium sorbate, Caprylyl glycol, Sodium hydroxide, Laureth-12, Hydrolyzed wheat protein, Lecithin, Disodium phosphate, Hydrolyzed soy protein, Carbomer, Dextran, Ethylhexylglycerin, Sodium lactate, Tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate, Sodium phosphate, Xanthan gum, Triethanolamine, Acrylates copolymer
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Worth comparing, line by line.
Match % combines shared ingredients, the first five ingredients, shared actives and hero ingredients, irritancy (lower counts in the alternative's favour), texture and body area. Only products in the same routine step are compared.
| Peter Thomas RothPeptide 21 Lift & Firm MoisturizerYOUR PRODUCT | BIOHEAL BOHProbioderm 3D Lifting Cream | MEDI-PEELPeptide 9 Volume Tox Cream Pro | Image skincareThe MAX Stem Cell Creme | |
|---|---|---|---|---|
| Match | — | 44% | 41% | 41% |
| Price | $56.00 | $27.99−$28.01 | $26.33−$29.67 | $69.77+$13.77 |
| Shared key ingredients | — | 13 of 33 | 12 of 33 | 9 of 33 |
| Key difference | — | Acetyl Tetrapeptide-5 | Acetyl Dipeptide-1 Cetyl Ester | Tetrahexyldecyl Ascorbate |
| Irritancy | Medium | Medium | Medium | Medium |
| Drying alcohol | — | — | — | — |
| View product | Shop | Shop | Shop |
More alternatives: Ginger 6 Energizing PEPTI CreamClinique Smart Clinical Repair Wrinkle Correcting Rich Cream
Product summary
"Peter Thomas Roth - Peptide 21 Lift & Firm Moisturizer" is a well-rounded moisturizing product. As we expect from a proper moisturizer, the formula includes a combo of effective humectants and emollients. These are the two different types of ingredients that are essential for improving the skin hydration and supporting a healthy skin barrier. Acetyl hexapeptide-8, acetyl octapeptide-3, dextran, glycerin and mannitol in this product (humectants) attract water molecules to the upper layer of the skin (the water comes from the outside air or from the deeper layers of the skin if the air is dry). Emollients in this formulation (palmitoyl tetrapeptide-7, palmitoyl tripeptide-1, tripeptide-1, phytosterols and dimethicone) help to reduce the moisture loss from the skin. They also soften the skin surface and relieve the feeling of dryness and tightness.
Ingredient callouts
- This moistruizer also contains peptides (trifluoroacetyl tripeptide-2 0.25% - 0.45%, palmitoyl tripeptide-5 0.45% - 0.65%, palmitoyl tripeptide-1 0.30% - 0.50%, palmitoyl tetrapeptide-7 0.30% - 0.55%, palmitoyl oligopeptide 0.30% - 0.60%, palmitoyl hexapeptide-19 0.25% - 0.45%, palmitoyl hexapeptide-12 0.30% - 0.55%, tripeptide-10 citrulline 0.40% - 0.60%, tripeptide-1 0.25% - 0.50%, hexapeptide-11 0.55% - 0.80%, dipeptide diaminobutyroyl benzylamide diacetate 0.50% - 0.75%, acetyl tetrapeptide-9 0.25% - 0.50%, acetyl tetrapeptide-2 0.25% - 0.45%, acetyl tetrapeptide-11 0.35% - 0.65%, acetyl octapeptide-3 0.25% - 0.45%, acetyl hexapeptide-8 0.30% - 0.60% and acetyl hexapeptide-1 0.40% - 0.60%). Peptides is a very big group of ingredients. They all consist of a different combination of amino-acids. Our skin produces peptides naturally. Some of them work as natural anti-biotics, promote wound-healing and production of collagen. The scientists are still studying how effective the topical application of peptides is, but it is very likely that peptides in skincare are helpful. They might be able to support skin barrier restoration and even have an anti-aging benefit. At the very least, they certainly help attract water to the skin and support the hydration in this way.
Irritation risk
This product does not contain known common irritants and is suitable for sensitive skin. We assess the overall irritancy of this moisturizer to be medium. For a detailed overview of all potential irritants: click here
You can see the detailed formula review with the breakdown of all actives in the product and the full ingredient list with estimated concentrations in the tables below.
Price
The product retails from 95.00$ up to 103.00$ in the United States, for 172.97A$ in Australia, from 56.40£ up to 117.50£ in the United Kingdom and from 119.70CA$ up to 124.00CA$ in Canada.
For a detailed price comparison: click here.
Sources cited in this review
Every concentration estimate and effectiveness label is anchored to one of these 18 studies and safety reviews.
- 1
- 2
- 3Final Report on the Safety Assessment of Dimethicone Copolyoljournals.sagepub.com
- 4
- 5Squalene and its potential clinical useseuropepmc.org
- 6
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